Results 121 to 130 of about 4,008 (211)

DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation

Journal of Molecular Cell Biology
Abstract Neuroblastoma (NB) is the most common extracranial solid tumor in children. Despite treatment advances, the survival rates of high-risk NB patients remain low. This highlights the urgent need for a deeper understanding of the molecular mechanisms driving NB progression to support the development of new therapeutic strategies. In
Yaqi Yang, Jiejun Wen, Susu Lou, Yali Han, Yi Pan, Ying Zhong, Qiao He, Yinfeng Zhang, Xi Mo, Jing Ma, Nan Shen   +10 more
openaire   +2 more sources

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, Volume 13, Issue 16, 18 March 2026.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Lactate‐induced metabolic reprogramming of TAMs impairs antigen presentation capacity via C/EBPα–CD74 axis in oral squamous cell carcinoma

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
• CD74hi TAMs correlate with favourable prognosis in OSCC. • Lactate reprograms TAMs metabolism and increases mitochondrial respiration. • C/EBPα acetylation suppresses CD74 and impairs antigen presentation. • Restoring CD74 enhances T‐cell activation and limits OSCC progression.
Mengyao Wang, Mengqi Wang, Zizhen Gong, Fanrui Zeng, Zihui Ni, Rundong Zhai, Weiwen Zhu, Jiayi Zhang, Laikui Liu   +8 more
wiley   +1 more source

Histone Changes as a Response to Lactic Acid Selection in Cells of Austrofundulus limnaeus [PDF]

The killifish Austrofundulus limnaeus is an extremophile native to small temporary ponds of Venezuela. Normal embryonic development of A. limnaeus is segmented into up to three stages of metabolic depression (diapause), and both developing and diapausing
Hughes, Chelsea, Podrabsky, Jason, Tran, Lori   +2 more
core   +1 more source

Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance [PDF]

Lactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of the central nervous system (CNS).
Jiaxin Tian, Jingyu Dong, Jinpeng Zhou, Ruidan Zhang, Sijia Hao, Tongyu Zhang, Yang Tian, Yiyan Chen   +7 more
core   +1 more source

Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma

Cell Death Discovery
Histone lactylation has been reported to involve in tumorigenesis and development. However, its biological regulatory mechanism in endometrial carcinoma (EC) is yet to be reported in detail.
Sitian Wei, Jun Zhang, Rong Zhao, Rui Shi, Lanfen An, Zhicheng Yu, Qi Zhang, Jiarui Zhang, Yuwei Yao, Haojia Li, Hongbo Wang   +10 more
doaj   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Microglia lactylation in relation to central nervous system diseases [PDF]

The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis. Microglia, as innate immune cells, play important roles in the maintenance of central nervous system homeostasis, injury response ...
Dong, Jianhong, Fan, Ziwei, Jia, Mengxian, Mo, Nan, Tong, Lily, Wang, Ying, Yang, Hui, Yue, Juanqing   +7 more
core   +1 more source

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

Downregulating Platelet Endothelial Cell Adhesion Molecule‐1 Enhances Learning and Memory and Alleviates Hallmark Pathologies in Alzheimer's Disease

MedComm, Volume 7, Issue 3, March 2026.
CD31 upregulation in 5xFAD mice activates STAT1/Irf1 signaling, driving abnormal gene transcription, Aβ and tau accumulation, microglial activation, and neuroinflammation, leading to cognitive decline. Systemic CD31 knockdown suppresses STAT1/Irf1 activity, restores gene expression balance, reduces Aβ and tau pathologies, alleviates neuroinflammation ...
Qiuzhi Zhou, Fei Sun, Yao Zhang, Xiaojian Cao, Mengzhu Li, Haitao Yu, Tao Jiang, Shihong Li, Weixia Wang, Jiazhao Xie, Ting He, Yanchao Liu, Xiuping Liu, Ying Yang, Dan Ke, Xiao‐Chuan Wang, Enjie Liu, Jian‐Zhi Wang   +17 more
wiley   +1 more source