Results 201 to 210 of about 4,008 (211)

Histone Lysine Lactylation Regulates Gene Expression

Cancer Discovery, 2019
Abstract A previously unknown histone modification, lysine lactylation, was found in mouse and human cells.
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Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis

Cell Metabolism
Histone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate lactyl-coenzyme A (CoA) and how this process is regulated remains unknown.
Ruilong Liu, Xuelian Ren, Yae Eun Park, Huixu Feng, Xinlei Sheng, Xiaohan Song, Roya AminiTabrizi, Hardik Shah, Lingting Li, Yu Zhang, Kalil G. Abdullah, Sarah Dubois-Coyne, Hening Lin, Philip A. Cole, Ralph J. DeBerardinis, Samuel K. McBrayer, He Huang, Yingming Zhao   +17 more
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Augmentation of scleral glycolysis promotes myopia through histone lactylation

Cell Metabolism
Myopia is characterized of maladaptive increases in scleral fibroblast-to-myofibroblast transdifferentiation (FMT). Scleral hypoxia is a significant factor contributing to myopia, but how hypoxia induces myopia is poorly understood. Here, we showed that myopia in mice and guinea pigs was associated with hypoxia-induced increases in key glycolytic ...
Xiaolei, Lin, Yi, Lei, Miaozhen, Pan, Changxi, Hu, Bintao, Xie, Wenjing, Wu, Jianzhong, Su, Yating, Li, Yuhan, Tan, Xiaohuan, Wei, Zhengbo, Xue, Ruiyan, Xu, Mengqi, Di, Hanyu, Deng, Shengcong, Liu, Xingxing, Yang, Jia, Qu, Wei, Chen, Xiangtian, Zhou, Fei, Zhao   +19 more
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Histone lactylation drives CD8+ T cell metabolism and function

Nature Immunology
The activation and functional differentiation of CD8+ T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification; however, the relevance of histone lactylation in the context of CD8+ T cell activation and function is not known.
Deblina Raychaudhuri, Pratishtha Singh, Bidisha Chakraborty, Mercedes Hennessey, Aminah J. Tannir, Shrinidhi Byregowda, Seanu Meena Natarajan, Abel Trujillo-Ocampo, Jin Seon Im, Sangeeta Goswami   +9 more
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Both L-lactyl and D-lactyl enantiomers modify histones in mouse testis

Abstract Dynamic histone post-translational modifications are crucial to precisely orchestrate gene expression programs. The recently discovered histone lysine lactylation has already been explored in various pathological contexts, but less in normal tissues.
Julie Manessier, Hassan Hijazi, Sabine Brugière, Marie Courçon, Christophe Masselon, Alberto de la Iglesia, Julie Cocquet, Delphine Pflieger   +7 more
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Comprehensive review of histone lactylation: Structure, function, and therapeutic targets

Biochemical Pharmacology
Histone lysine lactylation (Kla) has emerged as a distinct epigenetic modification that differs markedly from established acylation modifications through the unique addition of a lactyl group to a lysine residue. Such modifications not only alter nucleosome structure but also significantly impact chromatin dynamics and gene expression, thus playing a ...
Kaiwen Xu, Keyi Zhang, Yanshuang Wang, Yue Gu   +3 more
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Lumican promotes calcific aortic valve disease through H3 histone lactylation

European Heart Journal
Abstract Background and Aims Valve interstitial cells (VICs) undergo a transition to intermediate state cells before ultimately transforming into the osteogenic cell population, which is a pivotal cellular process in calcific aortic valve disease (CAVD).
Yuming Huang, Chunli Wang, Tingwen Zhou, Fei Xie, Zongtao Liu, Haiying Xu, Ming Liu, Shunshun Wang, Lanqing Li, Qingjia Chi, Jiawei Shi, Nianguo Dong, Kang Xu   +12 more
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Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation

Circulation Research
BACKGROUND: Medial arterial calcification is a chronic systemic vascular disorder distinct from atherosclerosis and is commonly observed in patients with chronic kidney disease, diabetes, and aging individuals. We previously showed that NR4A3 (nuclear receptor subfamily 4 group A member 3), an orphan nuclear receptor, is a key ...
Wenqi Ma, Kangni Jia, Haomai Cheng, Hong Xu, Zhigang Li, Hang Zhang, Hongyang Xie, Hang Sun, Lei Yi, Zhiyong Chen, Shengzhong Duan, Motoaki Sano, Keiichi Fukuda, Lin Lu, Fei Gao, Ruiyan Zhang, Xiaoxiang Yan   +16 more
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Efficient synthesis of lactylated histone peptides enabled by a pre-prepared protected lactylated-lysine

Tetrahedron Letters, 2023
Qingyao Shu, Jian Fan, Bingji Wang, Jing Shi   +3 more
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Biochemistry and regulation of histone lysine l-lactylation

Nature Reviews Molecular Cell Biology
Xinlei Sheng, Hening Lin, Philip A. Cole, Yingming Zhao   +3 more
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