Results 31 to 40 of about 2,005,250 (367)
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications
Science, 2021 Cryo-EM uncovers polycomb interactions Polycomb family enzymes include the chromatin modifiers PRC1 and PRC2, which are involved in gene repression. Although the catalytic functions of these complexes are well known, their functional relationship is not.
V. Kasinath +8 more
semanticscholar +1 more source
mBio, 2020 Histone posttranslational modifications (PTMs) modulate several eukaryotic cellular processes, including transcription, replication, and repair. Vast arrays of modifications have been identified in conventional eukaryotes over the last 20 to 25 years ...
Swati Saha
doaj +1 more source
Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification
Cell Death and Disease, 2023 Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated immune responses and multiple organ dysfunction. The imbalance between hyperinflammation and immunosuppression is a crucial feature of sepsis immunity.
Dan Wu +3 more
doaj +1 more source
The Histone Modifications of Neuronal Plasticity
Journal of Neural Transplantation and Plasticity, 2021 Nucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation ...
Huixia Geng +3 more
semanticscholar +1 more source
Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease
Frontiers in Pharmacology, 2021 Chronic liver disease (CLD) represents a global health problem, accounting for the heavy burden of disability and increased health care utilization. Epigenome alterations play an important role in the occurrence and progression of CLD.
Qiuyu Cai +8 more
doaj +1 more source
Histone modifications centric-regulation in osteogenic differentiation
Cell Death Discovery, 2021 Histone modification critically contributes to the epigenetic control of gene expression by changing the configuration of chromatin and modifying the access of transcription factors to gene promoters.
Kun Li, Jinxiang Han, Ziqiang Wang
semanticscholar +1 more source
Modeling exon expression using histone modifications. [PDF]
PLoS ONE, 2013 Histones undergo numerous covalent modifications that play important roles in regulating gene expression. Previous investigations have focused on the effects of histone modifications on gene promoters, whereas efforts to unravel their effects on ...
Shijia Zhu +3 more
doaj +1 more source
Co-regulation of histone-modifying enzymes in cancer. [PDF]
PLoS ONE, 2011 Cancer is characterized by aberrant patterns of expression of multiple genes. These major shifts in gene expression are believed to be due to not only genetic but also epigenetic changes.
Abul B M M K Islam +4 more
doaj +1 more source
The roles of histone modifications in tumorigenesis and associated inhibitors in cancer therapy
Journal of the National Cancer Center, 2022 Histone modifications are key factors in chromatin packaging, and are responsible for gene regulation during cell fate determination and development. Abnormal alterations in histone modifications potentially affect the stability of the genome and disrupt
Yunkai Yang, Min Zhang, Yan Wang
doaj +1 more source
Reciprocal intronic and exonic histone modification regions in humans. [PDF]
, 2010 While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications ...
Guthrie, Christine +3 more
core +7 more sources