Implications of canonical histone H3.1 and histone variant H3.3 in cancer [PDF]
Open BiologyHistones are the fundamental building blocks of chromatin and serve as pivotal regulators of gene expression. Differential expression and mutations of H3.1 and H3.3 genes have been implicated in the pathogenesis of various cancer types. Mutations in H3.3,
Peng Wu, Li Wang, Ting Wen, Qiao Yi Chen
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Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures [PDF]
Nature CommunicationsUnique among viruses, some giant viruses utilize histones to organize their genomes into nucleosomes. Melbournevirus encodes a distinct H2B-H2A histone doublet variant in addition to the canonical H4-H3 and H2B-H2A doublets.
Alejandro Villalta +4 more
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Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility [PDF]
Nature Communications, 2023 Here the authors show that H2A.Z histone variant incorporation reduces the nucleosomal barrier for transcription. Furthermore their simulations reveal that H2A.Z facilitates spontaneous DNA unwrapping from the histone octamer and enhances nucleosome ...
Shuxiang Li +2 more
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Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi [PDF]
Epigenetics & ChromatinBackground Fusarium fujikuroi is a pathogen of rice causing diverse disease symptoms such as ‘bakanae’ or stunting, most likely due to the production of various natural products (NPs) during infection.
Anna K. Atanasoff-Kardjalieff +7 more
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Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1 [PDF]
BMC BiologyBackground The histone variant macroH2A (mH2A), the most deviant variant, is about threefold larger than the conventional histone H2A and consists of a histone H2A-like domain fused to a large Non-Histone Region responsible for recruiting PARP-1 to ...
Khalid Ouararhni +11 more
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Histone variants and modifications during abiotic stress response
Frontiers in Plant Science, 2022 Plants have developed multiple mechanisms as an adaptive response to abiotic stresses, such as salinity, drought, heat, cold, and oxidative stress. Understanding these regulatory networks is critical for coping with the negative impact of abiotic stress ...
Rocío Nunez-Vazquez +2 more
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A system for genome-wide histone variant dynamics in ES cells reveals dynamic MacroH2A2 replacement at promoters. [PDF]
PLoS Genetics, 2014 Dynamic exchange of a subset of nucleosomes in vivo plays important roles in epigenetic inheritance of chromatin states, chromatin insulator function, chromosome folding, and the maintenance of the pluripotent state of embryonic stem cells.
Ozlem Yildirim +5 more
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Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay
eLife, 2021 In eukaryotes, histone variant distribution within the genome is the key epigenetic feature. To understand how each histone variant is targeted to the genome, we developed a new method, the RhIP (Reconstituted histone complex Incorporation into chromatin
Hiroaki Tachiwana +9 more
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Histone variants and chromatin structure, update of advances
Computational and Structural Biotechnology Journal, 2023 Histone proteins are highly conserved among all eukaryotes. They have two important functions in the cell: to package the genomic DNA and to regulate gene accessibility.
Vladyslava Sokolova +2 more
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The histone variant H3.3 regulates the transcription of the hepatitis B virus
Annals of Hepatology, 2021 Introduction and Objectives: About 250 million people around the world are chronically infected with the hepatitis B virus (HBV). Those people are at risk of developing hepatocellular carcinoma.
Francisca Alvarez-Astudillo +5 more
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