Histone variants and cellular plasticity [PDF]
Trends in Genetics, 2015 The broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular signals and the DNA is the chromatin, a dynamic nucleoprotein complex that helps to mediate gene regulation.
Santoro, Stephen W, Dulac, Catherine
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Recent advances in malaria genomics and epigenomics [PDF]
, 2016 Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian +2 more
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ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S. +6 more
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A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. [PDF]
, 2019 Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress.
Brimacombe, Cedric A +8 more
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Epigenetic Regulation by Histone Methylation and Histone Variants [PDF]
Molecular Endocrinology, 2005 Epigenetics is the study of heritable changes in gene expression that are not mediated at the DNA sequence level. Molecular mechanisms that mediate epigenetic regulation include DNA methylation and chromatin/histone modifications. With the identification of key histone-modifying enzymes, the biological functions of many histone posttranslational ...
Peter, Cheung, Priscilla, Lau
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Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex [PDF]
, 2012 BACKGROUND: Mutations in the chromodomain helicase DNA binding protein 7 gene (CHD7) lead to CHARGE syndrome, an autosomal dominant multiple malformation disorder. Proteins involved in chromatin remodeling typically act in multiprotein complexes.
Batsukh, Tserendulam +7 more
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The specification and global reprogramming of histone epigenetic marks during gamete formation and early embryo development in C. elegans. [PDF]
PLoS Genetics, 2014 In addition to the DNA contributed by sperm and oocytes, embryos receive parent-specific epigenetic information that can include histone variants, histone post-translational modifications (PTMs), and DNA methylation.
Mark Samson +10 more
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The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation [PDF]
, 2011 Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant ...
Bowman, A. +6 more
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Cleavage-embryo genes and transposable elements are regulated by histone variant H2A.X
The Journal of Reproduction and Development, 2021 During mammalian preimplantation development, stimulation of zygotic genome activation (ZGA) and transposable elements (TEs) shapes totipotency profiling.
Kai-yi SUN +5 more
doaj +1 more source
TREEOME: A framework for epigenetic and transcriptomic data integration to explore regulatory interactions controlling transcription [PDF]
, 2015 Motivation: Predictive modelling of gene expression is a powerful framework for the in silico exploration of transcriptional regulatory interactions through the integration of high-throughput -omics data.
Budden, David M +2 more
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