Results 111 to 120 of about 33,958 (207)

Inflammatory Biomarkers Decay After First‐Line Antiretroviral Therapy Initiation With Dolutegravir/Lamivudine or Bictegravir/Emtricitabine/Tenofovir Alafenamide in Persons With HIV: A Substudy of a Randomized Clinical Trial

Health Science Reports, Volume 9, Issue 3, March 2026.
Analuz Fernandez, Sofía Scevola, Raul Rigo Bonin, Maria Saumoy, Arkaitz Imaz, Daniel Podzamczer, Juan Tiraboschi   +6 more
wiley   +1 more source

Mobile Powerhouses: Mitochondria Transfer via Tunnelling Nanotubes in Brain Health and Neurodegenerative Diseases

European Journal of Neuroscience, Volume 63, Issue 6, March 2026.
Within the brain microenvironment, mitochondria are preferentially transferred from glial cells to metabolically stressed neurons via tunnelling nanotubes (TNTs). This intercellular exchange restores bioenergetic homeostasis and contributes to mitochondrial quality control through transmitophagy.
Anna Henrich, Hannah Scheiblich
wiley   +1 more source

Leishmania donovani's protein tyrosine phosphatases interact with DUF21 and respond to environmental magnesium

The FEBS Journal, Volume 293, Issue 6, Page 1754-1770, March 2026.
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini, Hira Khursheed, Wen Wei Zhang, Isabelle Aubry, Greg Matlashewski, Michel L. Tremblay, Patrick Lypaczewski   +6 more
wiley   +1 more source

Immune Modulation of HIV-1 Reservoir Size in Early-Treated Neonates. [PDF]

J Infect Dis, 2023
Hartana CA, Broncano PG, Maswabi K, Ajibola G, Moyo S, Mohammed T, Maphorisa C, Makhema J, Powis KM, Lockman S, Burbelo PD, Gao C, Yu XG, Kuritzkes DR, Shapiro R, Lichterfeld M.   +15 more
europepmc   +1 more source

Phenotyping Viral Reservoirs to Reveal HIV-1 Hiding Places

Current HIV/AIDS Reports
Abstract Purpose of Review Despite suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist in various cell types and tissues and reignite active replication if therapy is stopped. Persistence of the viral reservoirs in people with HIV-1 (PWH) is the main obstacle to achieving a cure.
Chen, Wenxuan, Berkhout, Ben, Pasternak, Alexander O.   +2 more
openaire   +3 more sources

Artificial lipidation of proteins and peptides: from mechanism to clinical applications

The FEBS Journal, Volume 293, Issue 5, Page 1269-1284, March 2026.
Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley   +1 more source

Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and protein levels. [PDF]

Curr Opin HIV AIDS, 2023
Wong M, Wei Y, Ho YC.
europepmc   +1 more source

Towards inclusive HIV cure development: Identifying important and acceptable HIV cure attributes and strategies among people with HIV in the Netherlands

HIV Medicine, Volume 27, Issue 3, Page 442-458, March 2026.
Abstract Objectives Initial HIV cure interventions may not meet expert‐defined target product profiles (TPPs; desired treatment attributes). Understanding how people with HIV perceive ideal and likely HIV cure attributes is essential. This study examined which optimal TPP attributes people with HIV consider important and which minimum attributes and ...
Maaike A. J. Noorman, John B. F. de Wit, Tamika A. Marcos, Sarah E. Stutterheim, Thijs Albers, Kai J. Jonas, Chantal Den Daas   +6 more
wiley   +1 more source

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir. [PDF]

Nat Commun, 2023
Pardons M, Cole B, Lambrechts L, van Snippenberg W, Rutsaert S, Noppe Y, De Langhe N, Dhondt A, Vega J, Eyassu F, Nijs E, Van Gulck E, Boden D, Vandekerckhove L.   +13 more
europepmc   +1 more source

Gonorrhea Management in High‐, Limited‐ and No‐Resource Settings: Implications in the Context of Antimicrobial Resistance

International Journal of Dermatology, Volume 65, Issue 3, Page 444-455, March 2026.
ABSTRACT Gonorrhea, a common sexually transmitted infection caused by Neisseria gonorrhoeae, represents an escalating global public health threat due to antimicrobial resistance. The current review explores diverse approaches around the globe to gonorrhea management across various settings, with a focus on diagnostic strategies, treatment practices ...
Andrei Tanasov, Maciej Pastuszczak, George‐Sorin Tiplica   +2 more
wiley   +1 more source