Results 191 to 200 of about 34,792 (219)
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Treatment Implications of the Latent Reservoir for HIV‐1
2007Publisher Summary This chapter explores the definition and mechanism of the latent reservoir, its resistance and treatment implications, and the impact of the latent reservoir on future drug development. A viral reservoir is a cell type or anatomic location in which virus or virally infected cells persist with slower replication kinetics and/or ...
Susan, Peterson +3 more
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HIV-1 reservoir dynamics in CD4+ T cells
Current Opinion in HIV and AIDS, 2019To provide a summary of the recent data examining infected CD4+ T cell dynamics during ART and implications for cure strategies.HIV-1 cure is a worldwide unmet medical need. Although combination antiretroviral therapies effectively suppress HIV-1 replication in vivo, viral rebound occurs shortly after therapy cessation.
Katherine M, Bruner, Lillian B, Cohn
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CNS Persistence of HIV-1 in Children: the Untapped Reservoir
Current HIV/AIDS Reports, 2018The central nervous system (CNS) represents a potential HIV-1 reservoir that may need to be specifically targeted by remission strategies. Perinatally HIV-1-infected children and youth are exposed to HIV-1 at a critical period of brain development. This review summarizes the current literature regarding HIV-1 and the CNS in perinatal infection.HIV-1 ...
Ann, Chahroudi +2 more
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CNS as an HIV-1 reservoir; BBB and Drug Delivery
Journal of Neurovirology, 1999In September of last year, the National Institute of Neurological Disorders and Stroke (NINDS) sponsored an AIDS Program Panel meeting entitled `CNS as an HIV-1 Reservoir: BBB and Drug Delivery'. The main objective of this highly focused meeting was to discuss the latest understandings of systemic drug delivery to the brain and the dif®culties which ...
A P, Kerza-Kwiatecki, S, Amini
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NK cells as a reservoir for HIV-1
Trends in Molecular Medicine, 2002Introduction of highly active anti-retroviral therapy (HAART) for the treatment of HIV-1 has dramatically decreased plasma viral-load levels in many patients. However, the therapy can only eliminate circulating virus. Latently infected and long-living cells present a major hurdle in the eradication of HIV-1 in infected individuals.
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HIV-1 Compartmentalization and Reservoir Formation
2020With over 37 million people living with HIV-1, and over one million new infections occurring each year, HIV-1 continues to be a significant public health burden. Current therapies that eliminate viral replication are not curative and require life-long adherence, placing substantial economic, social, and physical burdens on people living with HIV-1. The
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Dynamic characteristics of HIV-1 reservoirs.
Current opinion in HIV and AIDS, 2009To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy.Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in HIV-infected individuals. Analyses of viral blips and genetic changes
Hwijin, Kim, Alan S, Perelson
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Current opinion in investigational drugs (London, England : 2000), 2003
HIV-1 infection can now be treated effectively in many patients in the developed world, using combination antiretroviral therapeutics, called highly active antiretroviral therapy (HAART). Nevertheless, these regimens do not cure HIV-1 infection. Residual disease is maintained via proviral latency in resting CD4+ T-lymphocytes and possibly monocytes ...
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HIV-1 infection can now be treated effectively in many patients in the developed world, using combination antiretroviral therapeutics, called highly active antiretroviral therapy (HAART). Nevertheless, these regimens do not cure HIV-1 infection. Residual disease is maintained via proviral latency in resting CD4+ T-lymphocytes and possibly monocytes ...
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HIV-1 reservoir landscape of post-treatment control
Current Opinion in HIV and AIDSPurpose of review This review explores the viral reservoir landscape in individuals who control viral replication after treatment interruption (TI), designated as post-treatment controllers (PTCs).
Caroline, Charre +2 more
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In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure
Annual Review of Pathology: Mechanisms of Disease, 2022Janet Siliciano, Robert Siliciano
exaly