Results 181 to 190 of about 34,792 (219)
Some of the next articles are maybe not open access.
The prostate as a reservoir for HIV-1
AIDS, 2004As the prostate can harbor bacterial and fungal pathogens, it was investigated as a reservoir for HIV. Nine men chronically infected with HIV participated in a crossover trial in which weekly semen samples were collected with and without previous prostate massage (PM).
Davey M, Smith +5 more
openaire +2 more sources
Immune control of HIV-1 reservoirs
Current Opinion in HIV and AIDS, 2013To discuss the recent major advances in the understanding of how host immune defenses contribute to HIV reservoir control.Immune control of HIV-1 reservoirs is a two-step process: viral replication activation from latent reservoirs followed by elimination of virus-expressing cells by the host.
Brigitte, Autran +2 more
openaire +2 more sources
Markers of the HIV-1 reservoir
Current Opinion in HIV and AIDS, 2018The HIV-1 reservoir is composed of infected cells poised to replicate and spread the virus upon treatment interruption. It constitutes the main obstacle toward an HIV-1 cure. Whether marker(s) may allow the detection of cells that form the reservoir is an outstanding question.
Timothée, Bruel, Olivier, Schwartz
openaire +2 more sources
Clinics in Laboratory Medicine, 2002
In most infected individuals, HIV-1 replicates high levels throughout the duration of infection, including the clinically quiescent phase of disease. The level of this active viral replication correlates directly with disease progression and survival.
openaire +2 more sources
In most infected individuals, HIV-1 replicates high levels throughout the duration of infection, including the clinically quiescent phase of disease. The level of this active viral replication correlates directly with disease progression and survival.
openaire +2 more sources
Current Infectious Disease Reports, 1999
The success of antiretroviral therapy for HIV-1 infection has generated interest in mechanisms by which the virus can persist in the body despite the presence of drugs that effectively inhibit key steps in the virus life cycle. There are several potential cellular and anatomic reservoirs for HIV-1.
openaire +2 more sources
The success of antiretroviral therapy for HIV-1 infection has generated interest in mechanisms by which the virus can persist in the body despite the presence of drugs that effectively inhibit key steps in the virus life cycle. There are several potential cellular and anatomic reservoirs for HIV-1.
openaire +2 more sources
Quantification of the reservoir of HIV-1
Trends in Microbiology, 1997germinal centres can be differentiated by the type of in situ signal seen: infected mononuclear cells give a localized signal over a single cell, and trapped virions give a diffuse signal over germinal centres. The use of radioactive probes allows an estimate of viral copy number to be made (calculated using the specific activity of the probe, the ...
openaire +2 more sources
The Importance of Tissue Sanctuaries and Cellular Reservoirs of HIV-1
Current HIV Research, 2022Purpose of Review: There have been significant developments in the treatment of people living with HIV-1/AIDS with current antiretroviral therapies; however, these developments have not been able to achieve a functional or sterilizing cure for HIV-1.
William, Kalada, Theodore James, Cory
openaire +2 more sources
The Challenge of Viral Reservoirs in HIV-1 Infection
Annual Review of Medicine, 2002▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a replication-competent form of the virus accumulates and persists with more stable kinetic properties than the main pool of actively replicating virus. This article reviews several cell types and anatomical sites proposed as potential reservoirs for HIV-1.
Joel N, Blankson +2 more
openaire +2 more sources
Analyzing the unperturbed HIV-1 T cell reservoir
Trends in Immunology, 2023The latent reservoir for HIV-1 prevents cure but is difficult to characterize due to the low frequency of latently infected cells and the absence of unique markers. Sun et al. used single cell analysis of T cell surface phenotypes to provide evidence for immune selection of reservoir cells.
Brianna, Lopez, Robert F, Siliciano
openaire +2 more sources
HIV-1 in semen: an isolated virus reservoir
The Lancet, 1997/L, no known infected, andnormal genitourological examination at the time ofspecimen donation. Protease-gene sequences weredetermined for 11 blood and eight semen virus clones frompatient A who had not received antiretroviral therapy, andfrom nine blood and nine semen virus clones from patient Bwho had been on antiretroviral therapy for several years ...
R A, Byrn +4 more
openaire +2 more sources