Results 181 to 190 of about 34,607 (204)

Macrophage HIV-1 infection and the gastrointestinal tract reservoir

Journal of Leukocyte Biology, 2003
AbstractExcluding parenteral transmissions, virtually all vertical and homosexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs via the gastrointestinal tract. Cellular routes implicated in the translocation of virus across the epithelium include M cells, dendritic cells, and epithelial cells.
Phillip D, Smith, Gang, Meng, Jesus F, Salazar-Gonzalez, George M, Shaw   +3 more
openaire   +2 more sources

HIV-1 Compartmentalization and Reservoir Formation

2020
With over 37 million people living with HIV-1, and over one million new infections occurring each year, HIV-1 continues to be a significant public health burden. Current therapies that eliminate viral replication are not curative and require life-long adherence, placing substantial economic, social, and physical burdens on people living with HIV-1. The
openaire   +1 more source

Dynamic characteristics of HIV-1 reservoirs.

Current opinion in HIV and AIDS, 2009
To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy.Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in HIV-infected individuals. Analyses of viral blips and genetic changes
Hwijin, Kim, Alan S, Perelson
openaire   +1 more source

Eliminating HIV-1 reservoirs.

Current opinion in investigational drugs (London, England : 2000), 2003
HIV-1 infection can now be treated effectively in many patients in the developed world, using combination antiretroviral therapeutics, called highly active antiretroviral therapy (HAART). Nevertheless, these regimens do not cure HIV-1 infection. Residual disease is maintained via proviral latency in resting CD4+ T-lymphocytes and possibly monocytes ...
openaire   +1 more source

In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure

Annual Review of Pathology: Mechanisms of Disease, 2022
Janet D Siliciano, Robert F Siliciano
exaly  

An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status

Cell Host and Microbe, 2023
Hiroshi TAkata, Peeriya Prueksakaew
exaly  

The reservoir of latent HIV

Frontiers in Cellular and Infection Microbiology, 2022
Chuanyun Li
exaly  

HIV-1 reservoirs

Science, 1996
openaire   +1 more source

On HIV-1 latency and viral reservoirs

2015
HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and anatomical reservoirs. This thesis concerns several problematic issues of HIV-1 persistence, including ways to measure and monitor both the virus at low viral concentrations and the depletion of the reservoir.
openaire   +1 more source

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection

Cell Metabolism, 2019
José Carlos Valle-Casuso, Mathieu Angin, StevenN Volant   +2 more
exaly