Results 171 to 180 of about 34,607 (204)
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Quantification of the reservoir of HIV-1
Trends in Microbiology, 1997germinal centres can be differentiated by the type of in situ signal seen: infected mononuclear cells give a localized signal over a single cell, and trapped virions give a diffuse signal over germinal centres. The use of radioactive probes allows an estimate of viral copy number to be made (calculated using the specific activity of the probe, the ...
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The Importance of Tissue Sanctuaries and Cellular Reservoirs of HIV-1
Current HIV Research, 2022Purpose of Review: There have been significant developments in the treatment of people living with HIV-1/AIDS with current antiretroviral therapies; however, these developments have not been able to achieve a functional or sterilizing cure for HIV-1.
William, Kalada, Theodore James, Cory
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The Challenge of Viral Reservoirs in HIV-1 Infection
Annual Review of Medicine, 2002▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a replication-competent form of the virus accumulates and persists with more stable kinetic properties than the main pool of actively replicating virus. This article reviews several cell types and anatomical sites proposed as potential reservoirs for HIV-1.
Joel N, Blankson +2 more
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Analyzing the unperturbed HIV-1 T cell reservoir
Trends in Immunology, 2023The latent reservoir for HIV-1 prevents cure but is difficult to characterize due to the low frequency of latently infected cells and the absence of unique markers. Sun et al. used single cell analysis of T cell surface phenotypes to provide evidence for immune selection of reservoir cells.
Brianna, Lopez, Robert F, Siliciano
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HIV-1 in semen: an isolated virus reservoir
The Lancet, 1997/L, no known infected, andnormal genitourological examination at the time ofspecimen donation. Protease-gene sequences weredetermined for 11 blood and eight semen virus clones frompatient A who had not received antiretroviral therapy, andfrom nine blood and nine semen virus clones from patient Bwho had been on antiretroviral therapy for several years ...
R A, Byrn +4 more
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Treatment Implications of the Latent Reservoir for HIV‐1
2007Publisher Summary This chapter explores the definition and mechanism of the latent reservoir, its resistance and treatment implications, and the impact of the latent reservoir on future drug development. A viral reservoir is a cell type or anatomic location in which virus or virally infected cells persist with slower replication kinetics and/or ...
Susan, Peterson +3 more
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HIV-1 reservoir dynamics in CD4+ T cells
Current Opinion in HIV and AIDS, 2019To provide a summary of the recent data examining infected CD4+ T cell dynamics during ART and implications for cure strategies.HIV-1 cure is a worldwide unmet medical need. Although combination antiretroviral therapies effectively suppress HIV-1 replication in vivo, viral rebound occurs shortly after therapy cessation.
Katherine M, Bruner, Lillian B, Cohn
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CNS Persistence of HIV-1 in Children: the Untapped Reservoir
Current HIV/AIDS Reports, 2018The central nervous system (CNS) represents a potential HIV-1 reservoir that may need to be specifically targeted by remission strategies. Perinatally HIV-1-infected children and youth are exposed to HIV-1 at a critical period of brain development. This review summarizes the current literature regarding HIV-1 and the CNS in perinatal infection.HIV-1 ...
Ann, Chahroudi +2 more
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CNS as an HIV-1 reservoir; BBB and Drug Delivery
Journal of Neurovirology, 1999In September of last year, the National Institute of Neurological Disorders and Stroke (NINDS) sponsored an AIDS Program Panel meeting entitled `CNS as an HIV-1 Reservoir: BBB and Drug Delivery'. The main objective of this highly focused meeting was to discuss the latest understandings of systemic drug delivery to the brain and the dif®culties which ...
A P, Kerza-Kwiatecki, S, Amini
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NK cells as a reservoir for HIV-1
Trends in Molecular Medicine, 2002Introduction of highly active anti-retroviral therapy (HAART) for the treatment of HIV-1 has dramatically decreased plasma viral-load levels in many patients. However, the therapy can only eliminate circulating virus. Latently infected and long-living cells present a major hurdle in the eradication of HIV-1 in infected individuals.
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