Results 51 to 60 of about 33,958 (207)

Lenalidomide potentially reduced the level of cell- associated HIV RNA and improved persistent inflammation in patients with HIV-associated cryptococcal meningitis a pilot study

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundThe HIV-1 reservoir is a major barrier to curative strategies. Inflammation is an important factor for HIV-1 reservoir persistence. Lenalidomide regulates inflammatory cytokines efficiently.
Xiang Liu, Xueling Zhu, Xiaorong Peng, Ran Tao, Zhikai Wan, Jiangjin Hui, Yongzheng Guo, Ying Hang, Biao Zhu   +8 more
doaj   +1 more source

Towards an HIV-1 cure: measuring the latent reservoir [PDF]

Trends in Microbiology, 2015
The latent reservoir (LR) of HIV-1 in resting memory CD4(+) T cells serves as a major barrier to curing HIV-1 infection. While many PCR- and culture-based assays have been used to measure the size of the LR, correlation between results of different assays is poor and recent studies indicate that no available assay provides an accurate measurement of ...
Katherine M, Bruner, Nina N, Hosmane, Robert F, Siliciano   +2 more
openaire   +2 more sources

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes.

PLoS Pathogens
Human Immunodeficiency Virus type 1 (HIV-1) is responsible for the global HIV/AIDS epidemic and the establishment of an integrated HIV-1 reservoir remains the primary obstacle to cure.
Ghazal Sadri, Steven T Nadakal, William Lauer, Justin Kos, Parmit K Singh, Erin Elliott, Catherine W Kaiser, Easton E Ford, Nadia Richardson, Kaitlyn M Shields, Elizabeth Hudson, Noemi L Linden, Ali Danesh, James Powell, Peter Warburton, Juan Soto, Matthew Emery, Gintaras Deikus, Guinevere Q Lee, Susanna L Lamers, Steven J Reynolds, Ronald Galiwango, Jessica L Prodger, Stephen Tomusange, Taddeo Kityamuweesi, Tina Han, R Brad Jones, Aaron A R Tobian, Alan N Engelman, Robert Sebra, Susan Morgello, Andrew D Redd, David Sachs, Eric Rouchka, Melissa L Smith   +34 more
doaj   +1 more source

Eradication of HIV-1 latent reservoirs through therapeutic vaccination [PDF]

AIDS Research and Therapy, 2017
Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such as cancer, imaging, and genetic ...
Pankrac, Joshua, Klein, Katja, Mann, Jamie F S   +2 more
openaire   +4 more sources

Clinical Pharmacology Quality Assurance Program for Global HIV and Co‐Infection Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
When the acquired immunodeficiency syndrome emerged in the 1980s, the United States National Institutes of Health established research networks to conduct clinical trials with the pharmaceutical industry to identify effective antiretroviral therapeutics.
Robin DiFrancesco, Troy D. Wood, Raymond Cha, Jill S. Hochreiter, Susan L. Rosenkranz, Mona Farhad, Kyle R. Whitson, Connor E. Gould, Lauren E. Hill, Linda L. Hale, Philip H. Lindhorst, Diala Ghazal, Charlene R. Taylor, Madiha Quraishi, Suzanne M. Siminski, Yoninah Cramer, Heather L. Sprenger, Gene D. Morse   +17 more
wiley   +1 more source

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication [PDF]

Immunity, 2012
This Perspective proposes definitions for key terms in the field of HIV-1 latency and eradication. In the context of eradication, a reservoir is a cell type that allows persistence of replication-competent HIV-1 on a timescale of years in patients on optimal antiretroviral therapy. Reservoirs act as a barrier to eradication in the patient population in
Eisele, Evelyn, Siliciano, Robert F.
openaire   +2 more sources

Immunometabolic and Spatiotemporal Control of Tissue‐Resident Memory T Cell Biology

Barrier Immunity, EarlyView.
Tissue‐resident memory T (TRM) cells in barrier tissues provide a frontline defense against invading pathogens. Immune (Signals 1–3) and nutrient (Signal 4) cues play an integral role in directing TRM formation and heterogeneity. The spatial and temporal organization of these signals establishes durable TRM cells across tissues, enabling diverse ...
Jana L. Raynor, Hongbo Chi
wiley   +1 more source

HIV-1 Reservoir Association with Immune Activation

EBioMedicine, 2015
In this issue of EBioMedicine, Ruggiero and colleagues describe immune activation biomarkers associated with the size of the HIV reservoir in a carefully designed cross-sectional study. The cohort consists of a homogeneous sample of HIV-1-infected patients with long-term plasma HIV-1 RNA suppression under antiretroviral treatment (ART).
openaire   +5 more sources

Nanoparticles in microdroplets: Recent advances in microfluidic generators for producing functional microbeads

Droplet, EarlyView.
Functional hybrid microbeads with electrical, magnetic, and/or optical responsiveness have emerged as versatile platforms for biotechnology. This review highlights recent advances in microfluidic technologies for producing such microbeads, with a focus on incorporating functional nanoparticles in microdroplet systems.
  Bayinqiaoge, Chengchen Zhang, Shi‐Yang Tang   +2 more
wiley   +1 more source