Results 61 to 70 of about 33,958 (207)

Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security

Food Bioengineering, EarlyView.
ABSTRACT Probiotic foods have evolved from traditional fermented products to scientifically validated functional foods, defined by the FAO and WHO as live microorganism that confer a health benefit on the host when administered in adequate amounts, with effects being strain, does and end point specific.
Ashenafi Teklay Yaekob, Gebremedhin Gebreslassie, Etsay Mesele, Tesfakiros Semere   +3 more
wiley   +1 more source

Advancements in single-cell techniques for examining the HIV reservoir: pathways to a cure

mBio
Human immunodeficiency virus (HIV) is largely incurable, due to the presence of a viral reservoir, which primarily consists of resting CD4+ T cells and other long-lived cells like macrophages.
Nokuzola Mbhele, Benjamin Chimukangara, Lynn Tyers, Frank Maldarelli, Andrew D. Redd   +4 more
doaj   +1 more source

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

Nature Communications, 2020
The HIV reservoir is a major hurdle for a cure of HIV, but the factors determining its size and dynamics remain unclear. Here the authors show in a large cohort of 610 HIV-1 infected individuals, who are on suppressive ART for a median of 5.4 years, that
Chenjie Wan, Nadine Bachmann, Venelin Mitov, François Blanquart, Susana Posada Céspedes, Teja Turk, Kathrin Neumann, Niko Beerenwinkel, Jasmina Bogojeska, Jacques Fellay, Volker Roth, Jürg Böni, Matthieu Perreau, Thomas Klimkait, Sabine Yerly, Manuel Battegay, Laura Walti, Alexandra Calmy, Pietro Vernazza, Enos Bernasconi, Matthias Cavassini, Karin J. Metzner, Huldrych F. Günthard, Roger D. Kouyos, the Swiss HIV Cohort Study   +24 more
doaj   +1 more source

Key Players in HIV-1 Transcriptional Regulation: Targets for a Functional Cure

Viruses, 2020
HIV-1 establishes a life-long infection when proviral DNA integrates into the host genome. The provirus can then either actively transcribe RNA or enter a latent state, without viral production.
Luisa Mori, Susana T. Valente
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Delivering CRISPR to the HIV-1 reservoirs

Frontiers in Microbiology
Human immunodeficiency virus type 1 (HIV-1) infection is well known as one of the most complex and difficult viral infections to cure. The difficulty in developing curative strategies arises in large part from the development of latent viral reservoirs (LVRs) within anatomical and cellular compartments of a host.
Theodore E. Gurrola, Theodore E. Gurrola, Samuel N. Effah, Samuel N. Effah, Ilker K. Sariyer, Will Dampier, Will Dampier, Michael R. Nonnemacher, Michael R. Nonnemacher, Michael R. Nonnemacher, Brian Wigdahl, Brian Wigdahl, Brian Wigdahl   +12 more
openaire   +3 more sources

The impact of COVID‐19 on public perceptions of wild meat in Central Africa

People and Nature, EarlyView.
Abstract Wild meat is a significant source of food and income generation in Central Africa. However, there is little knowledge of how the assumed link between COVID‐19 and wild meat consumption has been discussed by the media and received by the public. In this study, we conducted media content analysis of 264 articles published in 2019–2020 related to
Yuhan Li, Lude Kinzonzi, Paul Loundou, Divin Malekani, Krossy Mavakala, Christian Mikolo Yobo, Katharine Abernethy, Matilda Eve Dunn, Donald Midoko Iponga, Robert Mwinyihali, Joss Wright, Eleanor Jane Milner‐Gulland, Lauren Coad, Juliet H. Wright, Daniel W. S. Challender   +14 more
wiley   +1 more source

Factors Associated with the Size of HIV DNA Reservoir

Chinese Medical Journal, 2017
Objective: To review the recent literatures related to the factors associated with the size of the HIV reservoir and their clinical significance. Data Sources: Literatures related to the size of HIV DNA was collected from PubMed published from 1999 to ...
Ni-Dan Wang, Tai-Sheng Li
doaj   +1 more source

Establishment of Drug‐Resistant HIV‐1 in Latent Reservoirs [PDF]

The Journal of Infectious Diseases, 2009
This article discusses strategies for the prevention of mother-to-child transmission of HIV in developing countries where interventions may not be affordable available feasible or safe. It comments on a report which used a novel method to characterize the latent reservoir in the presence of ongoing viral replication which provided strong evidence that ...
Viktor, Dahl, Sarah, Palmer
openaire   +2 more sources

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source