Results 1 to 10 of about 57,531 (234)

Effect and mechanism of HMG-CoA reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment based on the JAK/STAT pathway [PDF]

Diagnostic Pathology, 2023
Objective Our research was designed to figure out the influence and mechanism of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment ...
Wen Yuan, Hongjun Fan, Haibing Yang, Liang Tang, Zhiming Liu, Fan Ouyang, Wei Luo, Yong Yan   +7 more
doaj   +2 more sources

HMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study [PDF]

Scientific Reports
Statins are thought to have positive effects on migraine but existing data are inconclusive. We aimed to evaluate the causal effect of such drugs on migraines using Mendelian randomization. We used four types of genetic instruments as proxies for HMG-CoA
Kang Qu, Ming-xi Li, Peng Yu, International Headache Genetics Consortium, Bai-hua Wu, Miao Shi, Ming Dong   +6 more
doaj   +2 more sources

A novel approach to assessing the bioavailability of biopeptide inhibitor of HMG CoA reductase from germinated and ungerminated Kara Kratok (Phaseolus lunatus L.) [PDF]

PeerJ
Background The bioavailability of biopeptide compounds is a development challenge, mainly because of their resistance to the digestion system. This study aimed to determine the bioavailability of HMG CoA reductase biopeptide inhibitors from germinated ...
Cahyo Budiyanto, Andriati Ningrum, Agnes Murdiati, Retno Indrati   +3 more
doaj   +3 more sources

Molecular docking studies of Triphala with catalytic portion of HMG-CoA reductase enzyme [PDF]

Journal of HerbMed Pharmacology, 2023
Introduction: Triphala, consisting of three fruits, Phyllanthus emblica L. (Phyllanthaceae), Terminalia bellirica (Gaertn.) Roxb. (Combretaceae), and T.
Prasoborn Rinthong, Pawitra Pulbutr, Chawannuch Mudjupa   +2 more
doaj   +1 more source

Ligand-based pharmacophore modeling, molecular docking, and molecular dynamic studies of HMG-CoA reductase inhibitors

Informatics in Medicine Unlocked, 2022
Cardiovascular diseases (CVDs) are the leading causes of death, morbidity, and health expenses in developed and developing countries. Hyperlipidemia is the increase in plasma lipids and represents one of the main factors leading to CVDs.
Junaidin Junaidin, Dwintha Lestari, Muhammad Fariez Kurniawan, Nur Kusaira Khairul Ikram   +3 more
doaj   +1 more source

Hesperidin Interaction with HMG-CoA-Reductase Enzyme in Hypercholesterolemia: A Study in Silico

Berkala Kedokteran, 2021
: Dyslipidemia is a degenerative disease occurred with increased levels of fat and cholesterol levels in blood. One of the proteins used as anti-cholesterol is an HMG-CoA-Reductase.
Annisa Rizqi Dwi Oktaviani, Veronica Shania Aprillia, Eko Suhartono, Noer Komari   +3 more
doaj   +1 more source

HMG-CoA reductase inhibitors

The Journal of Japan Atherosclerosis Society, 2001
Publisher Summary This chapter focuses on the 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase enzyme that is known as the rate limiting enzyme in the cholesterol biosynthetic pathway. Today, HMG-CoA reductase inhibitors (statins) account for the large majority of prescriptions for lipid-lowering drugs in most countries.
D R, Illingworth, J A, Tobert
  +7 more sources

Localization of 3-hydroxy-3-methylglutaryl CoA reductase and 3-hydroxy-3-methylglutaryl CoA synthase in the rat liver and intestine is affected by cholestyramine and mevinolin

Journal of Lipid Research, 1988
In the normal fed rat, both 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase and HMG-CoA reductase are found in high concentrations in hepatocytes that are localized periportally.
A C Li, R D Tanaka, K Callaway, A M Fogelman, P A Edwards   +4 more
doaj   +1 more source

Activation of HMG-CoA reductase by microsomal phosphatase

Journal of Lipid Research, 1983
HMG-CoA reductase activity can be modulated by a reversible phosphorylation-dephosphorylation with the phosphorylated form of the enzyme being inactive and the dephosphorylated form, active. Phosphatases from diverse sources, including cytosol, have been
K R Feingold, M H Wiley, A H Moser, S R Lear, M D Siperstein   +4 more
doaj   +1 more source

Discordant regulation of proteins of cholesterol metabolism during the acute phase response

Journal of Lipid Research, 1995
Recent studies have shown that the administration of endotoxin (LPS) and cytokines to Syrian hamsters increases serum cholesterol levels, hepatic cholesterol synthesis, and the activity, protein levels, and mRNA levels of hepatic HMG-CoA reductase ...
K R Feingold, A S Pollock, A H Moser, J K Shigenaga, C Grunfeld   +4 more
doaj   +1 more source