Results 111 to 120 of about 57,531 (234)

Influence of dietary cholesterol, saturated and unsaturated lipid on 3-hydroxy-3-methylglutaryl CoA reductase activity in rabbit intestine and liver.

Journal of Lipid Research, 1981
To characterize further the behavior of the rate-limiting enzyme of cholesterol biosynthesis in animal species, we studied the kinetic properties and the influence of dietary lipid on intestinal and hepatic HMG-CoA reductase activity in the rabbit.
E F Stange, M Alavi, A Schneider, H Ditschuneit, J R Poley   +4 more
doaj   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Regulation of cholesterol biosynthesis and esterification by 25-hydroxycholesterol in a macrophage-like cell line: uncoupling by progesterone.

Journal of Lipid Research, 1984
The coordinated control of cholesterol biosynthesis and esterification by 25-hydroxycholesterol was studied in the macrophage-like cell line P388D1. Since 25-hydroxycholesterol rapidly stimulated incorporation of [3H]oleate into the cholesteryl ester ...
S C Miller, G Melnykovych
doaj   +1 more source

Comparative efficacy of seed biopriming and soil drenching with Bacillus altitudinis TM22 and Bacillus atrophaeus MCM61 on the suppression of Fusarium wilt of cotton

Pest Management Science, Volume 82, Issue 3, Page 2424-2445, March 2026.
Co‐application of Bacillus strains TM22 and MCM61 suppressed Fusarium wilt of cotton. Seed biopriming with Bacillus strains performed better than soil drenching. TM22 + MCM61 improved vegetative and physiological aspects in cotton plants. TM22 + MCM61 enhanced the activity of defense enzymes and defense gene expression.
Tahir Mahmood, Anam Moosa, Faisal Zulfiqar, Muhammad Naveed Aslam, Ohud Muslat Alharthy, Fatimah Hadadi, Ahmad F. Alhomodi, Seham Sater Alhelaify, Eman Fayad, Asim Alsenani, Salman Aloufi, Tolga İzgü   +11 more
wiley   +1 more source

Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol

Journal of Lipid Research, 1977
This paper describes the direct examination of HMG CoA reductase activity in rats treated with 20,25-diazacholesterol. Conversion of acetyl CoA and HMG CoA to mevalonate increased to over 200% of control values in the microsomes and in the 12,000 g ...
R Langdon, S El-Masry, R E Counsell
doaj   +1 more source

Effect of Genistein and L-Carnitine and Their Combination on Gene Expression of Hepatocyte HMG-COA Reductase and LDL Receptor in Experimental Nephrotic Syndrome [PDF]

Background: Nephrotic syndrome is a disorder that leads to hyperlipidemia. L-carnitine and genistein can effect on lipid metabolism and the syndrome. In the present study, we have delved into the separate and the twin-effects of L-carnitine and genistein
DJALALI, Mahmoud, ESHRAGHIAN, Mohammad-Reza, JAVANBAKHT, Mohammad Hassan, KOOHDANI, Fariba, MIRSHAFIEY, Abbas, RAMEZANI, Atena, SEDAGHAT, Reza, SIASSI, Fereydoon, YOUSEFINEJAD, Abbas, ZAREI, Mahnaz   +9 more
core  

Cholesterol and Malondialdehyde Contents of Broiler-Chicken Meat Supplemented with Indigofera Zolingeriana Top Leaf Meal [PDF]

, 2015
This research aimed to increase functional value of broiler-chicken meat containing high antioxidant and low cholesterol through substitution of soybean meal (SBM) with Indigofera zollingeriana top leaf meal (ILM). The experiment used 160 day old broiler
Abdullah, L. (L), Santi, M. A. (M), Sumiati, S. (Sumiati)   +2 more
core  

BiGraph‐DTA: Predicting drug–target interactions of hepatoprotective agents with graph convolutional networks

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Predicting drug–target affinity (DTA) is critical for discovering and developing hepatoprotective agents that can prevent and treat liver diseases. In this study, we propose BiGraph‐DTA, a new predictive model for identifying DTA score prediction for hepatoprotective compounds by combining graph convolutional networks and bidirectional long ...
Arief Sartono, Bambang Riyanto Trilaksono, Sophi Damayanti, Anto Satriyo Nugroho, Firdayani Firdayani   +4 more
wiley   +1 more source

Molecular mechanisms associated with rootstock–scion interactions in rubber trees

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Hevea brasiliensis (rubber tree) is the main source of natural rubber worldwide. In commercial plantations, high‐yield rubber tree clones are propagated by grafting onto seedling rootstocks. In this study, the transcriptomes of the RRIM 600 clone grafted on different rootstocks in southeastern Brazil were evaluated. Exclusively expressed genes
Wanderson Lima Cunha, Vinicius Mandolesi Rios, Alexandre Hild Aono, Danilo Augusto Sforça, Aline Da Costa Lima Moraes, Milene Silvestrini, Jose Marcos Dias Ferreira Junior, Antonio Lucio Mello Martins, Elaine Cristine Piffer Gonçalves, Paulo de Souza Gonçalves, Felipe Roberto Francisco, Anete Pereira de Souza   +11 more
wiley   +1 more source

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, Volume 13, Issue 7, 3 February 2026.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source