Results 51 to 60 of about 57,531 (234)

Inhibition of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase and Application of Statins as a Novel Effective Therapeutic Approach against Acanthamoeba Infections [PDF]

, 2013
Acanthamoeba is an opportunistic pathogen in humans, whose infections most commonly manifest as Acanthamoeba keratitis or, more rarely, granulomatous amoebic encephalitis.
Atteneri López-Arencibia, Basilio Valladares, Bienvenu, Brendan Loftus, Brown, Campochiaro, Carmen María Martín-Navarro, Chen, Cibickova, Clendening, Cortez, Gooi, Grellier, Haughan, Henriksen, Isabel de Fuentes, Istvan, Jacob Lorenzo-Morales, José E. Piñero, José Manuel García-Castellano, Khan, Khan, Kobbe, Kueckelhaus, Li, Lim, Lorenzo-Morales, Lorenzo-Morales, Macreadie, Marciano-Cabral, Martin-Navarro, Martin-Navarro, McBride, Mehdi, Mehdi, Melo, Montalvetti, Parquet, Raederstorff, Rozen, Rubén P. Machin, Schachter, Schuster, Shoff, Siddiqui, Smith, Soliman, Sutherland K. Maciver, Tamura, Urbina, Wong   +50 more
core   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Enhanced Production of Astaxanthin and Zeaxanthin by Paracoccus Sp. LL1 Through Random Mutagenesis

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Astaxanthin, a high‐value carotenoid with potent antioxidant and anti‐inflammatory activities, is increasingly in demand in various industries. This study reports the successful enhancement of astaxanthin and zeaxanthin production in Paracoccus sp. LL1 through random mutagenesis using ethyl methanesulfonate (EMS).
Anoth Maharjan, Beom Soo Kim
wiley   +1 more source

Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures [PDF]

, 2015
Simvastatin has been shown to have anti-inflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these anti-inflammatory effects are mediated have not been elucidated.
A Gierut, A Hilgendorff, AA Ajibade, BI Gavrila, BP Leung, C Arnaud, C Guiducci, C Guijarro, E Munro, EH Choy, FL Zhang, FM Brennan, FM Brennan, FX Zhang, G Falgarone, H Kanda, H Kanda, H Lin, H Methe, H Okamoto, H Radner, H Wesche, H Xu, I Zelvyte, J Qin, Jason Ferdjani, K Chaabo, KA Fitzgerald, KA Fitzgerald, KH Costenbader, KI Paraskevas, L Liu, LA O’Neill, Lisa Mullen, LM Mullen, M Khoury, M Ortego, M Yamamoto, M Yoshida, MA Gonzalez-Gay, QQ Huang, S Alzabin, S Doornum Van, Sandra Sacre, SL Chinault, SM Sacre, T Mosmann, TT Tang, U Schonbeck   +48 more
core   +1 more source

Trust first, concerns second: An international vignette study of older adults' preferences towards deprescribing statins

British Journal of Clinical Pharmacology, EarlyView.
Abstract This study investigated the attitudes and beliefs of older adults towards deprescribing statins in Australia, the United Kingdom and the United States, using an online, vignette‐based study. Presented with a hypothetical scenario in which a general practitioner advised stopping simvastatin, participants rated their level of agreement and ...
Sarah E. Vordenberg, Noelia Dulo, Carissa Bonner, Eliza Ferguson, Vincent D. Marshall, Kristie Rebecca Weir   +5 more
wiley   +1 more source

Cyclic AMP-sensitive activation of hepatic sterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Journal of Lipid Research, 1978
We previously showed that preincubation of a 10,000 g supernatant (S(10)) from rat liver for 20 min at 37 degrees C dramatically increased the subsequent incorporation of [(14)C]acetate into sterols.
C D Goodwin, S Margolis
doaj   +1 more source

Molecular Docking of Red Betel (Piper crocatum Ruiz & Pav) Bioactive Compounds as HMG-CoA Reductase Inhibitor

Jurnal Kimia Sains dan Aplikasi, 2021
Cholesterol plaque buildup in artery walls occurs due to oxidation of Low-Density Lipoprotein (LDL) molecules by free radicals, which are a risk factor for coronary heart disease. Piper crocatum contains active compounds that can act as HMG-CoA reductase
Bella Fatima Dora Zaelani, Mega Safithri, Dimas Andrianto   +2 more
doaj   +1 more source

Optimization, Validation and Application of Spectrophotometric Assay for 3-Hydroxy-3-methylglutarylcoenzyme A Reductase Activity [PDF]

, 2015
Purpose: To improve the sensitivity and specificity of spectrophotometric 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase activity assay.Methods: Spectrophotometric HMG-CoA reductase detection in male Wistar rat liver microsomes was optimized by
Gai Liang, Hao Kou, Hui Wang, Jie Ping, Ting-ting Wang, Trop J Pharm Res, Yu Guo   +6 more
core   +2 more sources

Mapping molluscan endocrinology: a systematic and critical appraisal

Biological Reviews, EarlyView.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis, Thomas H. Miller, Olwenn V. Martin, Alice Baynes   +3 more
wiley   +1 more source