Results 51 to 60 of about 2,854 (146)

Multi‐Omics Analysis Reveals Impacts of LincRNA Deletion on Yeast Protein Synthesis

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study demonstrates that the deletion of specific lincRNAs in yeast affects protein secretion. An engineered yeast strain, with multiple genetic modifications including lincRNA deletion, achieves a high yield of 4.1 g L⁻1 in fed‐batch cultivation.
Ling Qin, Yuyang Pan, Songlyu Xue, Zhibo Yan, Chufan Xiao, Xiufang Liu, Dan Yuan, Jin Hou, Mingtao Huang   +8 more
wiley   +1 more source

Advancements in Single‐Cell Proteomics and Mass Spectrometry‐Based Techniques for Unmasking Cellular Diversity in Triple Negative Breast Cancer

PROTEOMICS – Clinical Applications, Volume 19, Issue 1, January 2025.
ABSTRACT Background Triple‐negative breast cancer (TNBC) is an aggressive and complex subtype of breast cancer characterized by a lack of targeted treatment options. Intratumoral heterogeneity significantly drives disease progression and complicates therapeutic responses, necessitating advanced analytical approaches to understand its underlying biology.
Lakshmi Vineela Nalla, Aarika Kanukolanu, Madhuri Yeduvaka, Siva Nageswara Rao Gajula   +3 more
wiley   +1 more source

Exploration of In Situ Extraction for Enhanced Triterpenoid Production by Saccharomyces cerevisiae

Microbial Biotechnology, Volume 17, Issue 12, December 2024.
In situ extraction using isopropyl myristate (IPM) and β‐cyclodextrins (β‐CDs) enhances the production of triterpenoids in engineered Saccharomyces cerevisiae by facilitating the continuous extraction of intracellular products, thereby simplifying downstream processing and improving overall yield. ABSTRACT Plant‐derived triterpenoids are in high demand
Mariam Dianat, Sarah Straaten, Aldo Maritato, Daniel Wibberg, Tobias Busche, Lars M. Blank, Birgitta E. Ebert   +6 more
wiley   +1 more source

Effects of Fatty Acids from Avocados on Expression of the HMG1 Gene in Tetrahymena thermophila [PDF]

, 2018
The enzyme 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase (HMG) HMG catalyzes the ratelimiting step in the biosynthesis of cholesterol and is a common drug target for cholesterol reduction.
Phan, Jasmine, Kane, Connor, Otto-Hitt, Stefanie   +2 more
core   +2 more sources

Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry – A Review

Engineering in Life Sciences, Volume 24, Issue 10, October 2024.
ABSTRACT Squalene is a natural triterpenoid and a biosynthetic precursor of steroids and hopanoids in microorganisms, plants, humans, and other animals. Squalene has exceptional properties, such as its antioxidant activity, a high penetrability of the skin, and the ability to trigger the immune system, promoting its application in the cosmetic ...
Saseendran Shalu, Panam Kunnel Raveendranathan Karthikanath, Vinoth Kumar Vaidyanathan, Lars M. Blank, Andrea Germer, Palanisamy Athiyaman Balakumaran   +5 more
wiley   +1 more source

Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans

Advanced Science, Volume 11, Issue 35, September 18, 2024.
Otilonium bromide (OTB) demonstrates efficacy against Candida albicans by targeting Sec31, thereby impeding vesicle transport and ergosterol localization, ultimately inducing cytotoxic autophagy. C. albicans exhibits susceptibility to OTB because it does not act as a substrate of drug pumps.
Cheng Zhen, Li Wang, Yanru Feng, Malcolm Whiteway, Sijin Hang, Jinhua Yu, Hui Lu, Yuanying Jiang   +7 more
wiley   +1 more source

Differential Binding of HMG1, HMG2, and a Single HMG Box to Cisplatin-Damaged DNA

, 1996
The HMG box domain is a DNA binding domain present in the nonhistone chromosomal proteins HMG1 and HMG2 and in other proteins involved in the regulation of gene expression.
Marco E. Bianchi, Luca Falciola, Paul C. Billings, Engelsberg, B N, Bianchi, M E, Farid, R S, Beatrice N. Engelsberg, Ramy S. Farid, Falciola, L, Billings, P C   +9 more
core   +1 more source

Site‐directed genotype screening for elimination of antinutritional saponins in quinoa seeds identifies TSARL1 as a master controller of saponin biosynthesis selectively in seeds

Plant Biotechnology Journal, Volume 22, Issue 8, Page 2216-2234, August 2024.
Summary Climate change may result in a drier climate and increased salinization, threatening agricultural productivity worldwide. Quinoa (Chenopodium quinoa) produces highly nutritious seeds and tolerates abiotic stresses such as drought and high salinity, making it a promising future food source.
Mai Duy Luu Trinh, Davide Visintainer, Jan Günther, Jeppe Thulin Østerberg, Rute R. da Fonseca, Sara Fondevilla, Max William Moog, Guangbin Luo, Anton F. Nørrevang, Christoph Crocoll, Philip V. Nielsen, Sven‐Erik Jacobsen, Toni Wendt, Søren Bak, Rosa Laura López‐Marqués, Michael Palmgren   +15 more
wiley   +1 more source

Estrogen treatment induces elevated expression of HMG1 in MCF-7 cells

, 1998
The high mobility group (HMG)1 protein is a highly conserved and ubiquitous chromosomal protein found enriched in active chromatin, In this study, we have investigated the effect of estrogen on the expression of the human high mobility group protein HMG1
Lee, KLD, Lam, HYP, Chau, KY
core   +1 more source

The multifaceted functions of DNA‐PKcs: implications for the therapy of human diseases

MedComm, Volume 5, Issue 7, July 2024.
DNA‐PKcs is involved in nervous system diseases, senescence, asthma, cardiovascular disease, cancers, chronic kidney diseases, and rheumatoid arthritis. Abstract The DNA‐dependent protein kinase (DNA‐PK), catalytic subunit, also known as DNA‐PKcs, is complexed with the heterodimer Ku70/Ku80 to form DNA‐PK holoenzyme, which is well recognized as ...
Jinghong Wu, Liwei Song, Mingjun Lu, Qing Gao, Shaofa Xu, Ping‐Kun Zhou, Teng Ma   +6 more
wiley   +1 more source