Results 51 to 60 of about 2,248 (159)
Multi‐Omics Analysis Reveals Impacts of LincRNA Deletion on Yeast Protein Synthesis
Advanced Science, Volume 12, Issue 13, April 3, 2025.This study demonstrates that the deletion of specific lincRNAs in yeast affects protein secretion. An engineered yeast strain, with multiple genetic modifications including lincRNA deletion, achieves a high yield of 4.1 g L⁻1 in fed‐batch cultivation.
Ling Qin +8 more
wiley +1 more source
Interaction of Non-histone Chromosomal Proteins HMG1 and HMG2 with DNA [PDF]
European Journal of Biochemistry, 1977 Interaction between non-histone protein HMG1 or HMG2 and DNA has been studied by using thermal denaturation and circular dichroism (CD) spectroscopy. We have made the following observations. 1. The binding of each of these two proteins to DNA stabilizes the latter, as shown by an increase in melting temperature of 20 degrees C (from 45 degrees C to ...
S S, Yu +3 more
openaire +2 more sources
PROTEOMICS – Clinical Applications, Volume 19, Issue 1, January 2025.ABSTRACT Background Triple‐negative breast cancer (TNBC) is an aggressive and complex subtype of breast cancer characterized by a lack of targeted treatment options. Intratumoral heterogeneity significantly drives disease progression and complicates therapeutic responses, necessitating advanced analytical approaches to understand its underlying biology.
Lakshmi Vineela Nalla +3 more
wiley +1 more source
Exploration of In Situ Extraction for Enhanced Triterpenoid Production by Saccharomyces cerevisiae
Microbial Biotechnology, Volume 17, Issue 12, December 2024.In situ extraction using isopropyl myristate (IPM) and β‐cyclodextrins (β‐CDs) enhances the production of triterpenoids in engineered Saccharomyces cerevisiae by facilitating the continuous extraction of intracellular products, thereby simplifying downstream processing and improving overall yield. ABSTRACT Plant‐derived triterpenoids are in high demand
Mariam Dianat +6 more
wiley +1 more source
Advanced Science, Volume 11, Issue 35, September 18, 2024.Otilonium bromide (OTB) demonstrates efficacy against Candida albicans by targeting Sec31, thereby impeding vesicle transport and ergosterol localization, ultimately inducing cytotoxic autophagy. C. albicans exhibits susceptibility to OTB because it does not act as a substrate of drug pumps.
Cheng Zhen +7 more
wiley +1 more source
Plant Biotechnology Journal, Volume 22, Issue 8, Page 2216-2234, August 2024.Summary Climate change may result in a drier climate and increased salinization, threatening agricultural productivity worldwide. Quinoa (Chenopodium quinoa) produces highly nutritious seeds and tolerates abiotic stresses such as drought and high salinity, making it a promising future food source.
Mai Duy Luu Trinh +15 more
wiley +1 more source
Engineering of Yarrowia lipolytica for production of astaxanthin
Synthetic and Systems Biotechnology, 2017 Astaxanthin is a red-colored carotenoid, used as food and feed additive. Astaxanthin is mainly produced by chemical synthesis, however, the process is expensive and synthetic astaxanthin is not approved for human consumption. In this study, we engineered
Kanchana Rueksomtawin Kildegaard +5 more
doaj +1 more source
The multifaceted functions of DNA‐PKcs: implications for the therapy of human diseases
MedComm, Volume 5, Issue 7, July 2024.DNA‐PKcs is involved in nervous system diseases, senescence, asthma, cardiovascular disease, cancers, chronic kidney diseases, and rheumatoid arthritis. Abstract The DNA‐dependent protein kinase (DNA‐PK), catalytic subunit, also known as DNA‐PKcs, is complexed with the heterodimer Ku70/Ku80 to form DNA‐PK holoenzyme, which is well recognized as ...
Jinghong Wu +6 more
wiley +1 more source
New developments in biotechnology applied to microorganisms
EFSA Journal, Volume 22, Issue 7, July 2024.Abstract EFSA was requested by the European Commission (in accordance with Article 29 of Regulation (EC) No 178/2002) to provide a scientific opinion on the application of new developments in biotechnology (new genomic techniques, NGTs) to viable microorganisms and products of category 4 to be released into the environment or placed on the market as or
EFSA Panel on Genetically Modified Organisms (GMO) +25 more
wiley +1 more source
An HMG1-like protein facilitates Wnt signaling in Caenorhabditis elegans [PDF]
Genes & Development, 1999 We show that during Caenorhabditis elegans male spicule development, the specification of a glial versus neuronal cell fate in a canonical neurogenic sublineage is dependent on Wnt signaling. Inactivation of a Wnt signaling pathway mediated by the Wnt receptor LIN-17 transforms the SPD sheath cell into its sister, the SPD neuron.
Jiang, Lily I., Sternberg, Paul W.
openaire +3 more sources