Results 31 to 40 of about 2,248 (159)
Microbial Cell Factories, 2022 Background Amyrin is an important triterpenoid and precursor to a wide range of cosmetic, pharmaceutical and nutraceutical products. In this study, we metabolically engineered the oleaginous yeast, Yarrowia lipolytica to produce α- and β-amyrin on simple
Jing Kong +10 more
doaj +1 more source
Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway.
PLoS Genetics, 2008 Large numbers of gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. High mobility group 1 (HMG1) protein is a non-histone DNA-binding protein and is highly expressed in different types of tumors.
Nilabja Sikdar +4 more
doaj +1 more source
Frontiers in Microbiology, 2023 Aspergillus fumigatus is a common causative pathogen of aspergillosis. At present, triazole resistance of A. fumigatus poses an important challenge to human health globally. In this study, the biological characteristics and mechanisms of azole resistance
Meng Zeng +9 more
doaj +1 more source
Expression of HMG1 and metastasis of colorectal cancer [PDF]
International Journal of Colorectal Disease, 2009 Dear Editor: I read the recent publication by Huang et al. with a great interest. The expression on high-mobility group box-1 (HMG1) and its correlation to metastasis in colorectal cancer is reported in this study. Huang et al. reached to the conclusion that “The HMGI-C and HMGI(Y) quantitations by real-time RT-PCR are associated with Dukes’ staging ...
openaire +2 more sources
Bioresources and Bioprocessing, 2023 Because of its potent antioxidant effects, lycopene has been used in various industries including, but not limited to, food, medical, and cosmetic industries.
Zhen Luo +6 more
doaj +1 more source
Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry - A Review. [PDF]
Eng Life SciABSTRACT Squalene is a natural triterpenoid and a biosynthetic precursor of steroids and hopanoids in microorganisms, plants, humans, and other animals. Squalene has exceptional properties, such as its antioxidant activity, a high penetrability of the skin, and the ability to trigger the immune system, promoting its application in the cosmetic ...
Shalu S +5 more
europepmc +2 more sources
Solution structure of a DNA-binding domain from HMG1 [PDF]
Nucleic Acids Research, 1993 We have determined the tertiary structure of box 2 from hamster HMG1 using bacterial expression and 3D NMR. The all alpha-helical fold is in the form of a V-shaped arrowhead with helices along two edges and one rather flat face. This architecture is not related to any of the known DNA binding motifs.
Read, Christopher M. +4 more
openaire +3 more sources
Structure of the HMG box motif in the B‐domain of HMG1. [PDF]
The EMBO Journal, 1993 The conserved, abundant chromosomal protein HMG1 consists of two highly homologous, folded, basic DNA-binding domains, each of approximately 80 amino acid residues, and an acidic C-terminal tail. Each folded domain represents an 'HMG box', a sequence motif recently recognized in certain sequence-specific DNA-binding proteins and which also occurs in ...
H M, Weir +5 more
openaire +2 more sources
SRY, like HMG1, recognizes sharp angles in DNA. [PDF]
The EMBO Journal, 1992 HMG boxes are DNA binding domains present in chromatin proteins, general transcription factors for nucleolar and mitochondrial RNA polymerases, and gene- and tissue-specific transcriptional regulators. The HMG boxes of HMG1, an abundant component of chromatin, interact specifically with four-way junctions, DNA structures that are cross-shaped and ...
Ferrari, S +5 more
openaire +2 more sources
Host and Pathway Engineering for Enhanced Lycopene Biosynthesis in Yarrowia lipolytica
Frontiers in Microbiology, 2017 Carotenoids are a class of molecules with commercial value as food and feed additives with nutraceutical properties. Shifting carotenoid synthesis from petrochemical-based precursors to bioproduction from sugars and other biorenewable carbon sources ...
Cory Schwartz +3 more
doaj +1 more source