Results 11 to 20 of about 2,248 (159)
Environmental Circulation of Aspergillus fumigatus With Reduced Susceptibility to Agricultural Triazole in Brazil: Clonal Dissemination of Potentially Resistant Genotypes. [PDF]
MycosesABSTRACT Background Aspergillus fumigatus resistance to triazole antifungals poses an increasing global health concern. Moreover, the crossâresistance between azole antifungal agents used in clinical settings and those applied in agriculture has become an important emerging issue.
de Barros Rodrigues DK +9 more
europepmc +2 more sources
Microbiology Spectrum, 2023 Aspergillus fumigatus is a ubiquitous environmental mold that can cause severe disease in immunocompromised patients and chronic disease in individuals with underlying lung conditions. Triazoles are the most widely used class of antifungal drugs to treat
Ana C. O. Souza +5 more
doaj +1 more source
Horticulturae, 2023 Accurate and standardized quantification of reverse transcription PCR (qRT-PCR) results relies on the use of a dependable reference gene. The precise control of transgene expression in terms of both spatial and temporal aspects necessitates the ...
Yangyi Zheng +10 more
doaj +1 more source
Hmg1 Gene Mutation Prevalence in Triazole-Resistant Aspergillus fumigatus Clinical Isolates
Journal of Fungi, 2020 Recently, mutations in the 3-hydroxy-3-methylglutaryl-coenzyme-A-reductase-encoding gene (hmg1), a gene involved in ergosterol production, were associated with triazole-resistance in Aspergillus fumigatus.
Agustin Resendiz-Sharpe +9 more
doaj +1 more source
Journal of Fungi, 2023 Aspergillus fumigatus is a common human fungal pathogen that can cause a range of diseases. Triazoles are used to treat A. fumigatus infections, but resistance is increasing due to mutations in genes such as cyp51A, hmg1 and overexpression of efflux ...
Mariana Handelman, Nir Osherov
doaj +1 more source
Journal of Fungi, 2022 The antifungal resistance in non-fumigatus Aspergillus spp., as well as Aspergillus fumigatus, poses a major therapeutic challenge which affects the entire healthcare community.
Sanaz Nargesi +5 more
doaj +1 more source
The mechanism of sequence non-specific DNA binding of HMG1/2-box B in HMG1 with DNA [PDF]
Protein Engineering, Design and Selection, 1999 The DNA binding mechanism of box B in HMG1, a member of the sequence non-specific DNA binding HMG1/2-box family of proteins, has been examined by both mutation analyses and molecular modeling techniques. Substitution of the residue 102F, which is characteristically exposed to solvent, with a small hydrophobic amino acid affected its DNA binding ...
K, Saito, T, Kikuchi, M, Yoshida
openaire +2 more sources
A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. [PDF]
PLoS ONE, 2012 Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation.
Tomonori Takami +5 more
doaj +1 more source
Molecules, 2021 Invasive aspergillosis, mainly caused by Aspergillus fumigatus, can lead to severe clinical outcomes in immunocompromised individuals. Antifungal treatment, based on the use of azoles, is crucial to increase survival rates.
Irene Gonzalez-Jimenez +4 more
doaj +1 more source
Involvement of protein HMG1 in DNA replication [PDF]
FEBS Letters, 1984 Antibodies against HMG1 inhibit the incorporation of [3H]thymidine in Ehrlich ascites cell nuclei. By the use of specific inhibitors it is shown that HMG1 is needed for the action of the replicative DNA polymerase and not for the reparative one. This is supported by the fact that the addition of exogenous HMG1 to the nuclei enhances the replication ...
Alexandrova, Evdokia A. +2 more
openaire +2 more sources