Understanding multi-azole resistance in Aspergillus fumigatus: the impact of non-cyp51A mutation and efflux pump overexpression [PDF]
Frontiers in Fungal BiologyIntroductionAzole resistance in Aspergillus fumigatus is an emerging global concern, significantly limiting treatment options for aspergillosis. The present study aimed to investigate azole resistance mechanisms, focusing on non-cyp51A mutations and ...
Pooja Sen +3 more
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Molecular and Phenotypic Characterization of Multidrug-Resistant Aspergillus fumigatus Clinical Isolates in Republic of Korea [PDF]
Journal of FungiGenetic diversity and antifungal susceptibility profiles of Aspergillus fumigatus are critical for understanding the evolution of resistance in clinical and environmental settings. We performed comprehensive genomic characterization of A.
Yun Ha Lee +5 more
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Epidemiology, antifungal susceptibility and biological characteristics of clinical Aspergillus fumigatus in a tertiary hospital [PDF]
Scientific ReportsAzole resistance in Aspergillus fumigatus poses a significant clinical challenge globally. In this study, we analyzed 307 clinical A. fumigatus isolates from General Hospital of Ningxia Medical University in China, collected between July 2023 and July ...
Yuting Kang +4 more
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Integrative Transcriptomic and Target Metabolite Analysis as a New Tool for Designing Metabolic Engineering in Yeast [PDF]
BiomoleculesPrecision fermentation processes, especially when using edited microorganisms, demand accuracy in the bioengineering process to maximize the desired outcome and to avoid adverse effects.
Alejandro Lopez-Barbera +4 more
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A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1 [PDF]
Nature CommunicationsTriazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis.
Jeffrey M. Rybak +16 more
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Interaction of the HMG1 protein with nucleic acids
FEBS Letters, 1984 Binding constants have been measured for the interaction of the protein HMG1 with native DNA, denatured DNA and a number of polynucleotides at near‐physiological ionic strengths, using gel filtration and thermal denaturation. The interaction of HMG1 with DNA is shown to be noncooperative and reversible.
Shepelev, V.A. +2 more
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High prevalence of azole resistance among environmental Aspergillus fumigatus isolates from outdoor air in Madrid, Spain [PDF]
Frontiers in MicrobiologyIntroductionAspergillus fumigatus has been designated by the World Health Organization (WHO) as a critical fungal pathogen. Its spores are commonly present in the air and are inhaled daily.
Juan Carlos Soto-Debrán +12 more
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Genome-wide CRISPRi screen and proteomic profiling identify key genes related to ferulic acid’s antifungal activity [PDF]
mBioFungal pathogens of plants must overcome host-imposed stressors, including antimicrobial small molecules. Ferulic acid (FA), a plant-derived phenolic compound, induces fungal stress and cell death.
Ofri Levi +5 more
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Unveiling the genetic basis of floral scent formation in roses using weighted gene co-expression and protein-protein interaction network analyses [PDF]
Scientific ReportsRosa species hold considerable economic and medicinal importance, used in traditional medicine, essential oils, and landscaping. However, the mechanisms of floral scent formation in roses are not well understood, hindering genetic improvement.
Chan Xu +6 more
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INTERACTION OF DOXORUBICIN WITH DNA-HMG1 COMPLEX [PDF]
Journal of Sciences, Islamic Republic of Iran, 1995 In this study, the interaction of the anthracycline antibiotic doxorubicin with DNA-HMG 1 complex was investigated employing UV/VIS spectroscopy, thermal denaturation and DNA cellulose chromatography techniques.
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