Results 21 to 30 of about 2,248 (159)

A Cyp51B Mutation Contributes to Azole Resistance in Aspergillus fumigatus

Journal of Fungi, 2020
The emergence and spread of Aspergillus fumigatus azole resistance has been acknowledged worldwide. The main problem of azole resistance is the limited therapeutic options for patients suffering aspergillosis. Azole resistance mechanisms have been mostly
Irene Gonzalez-Jimenez, Jose Lucio, Jorge Amich, Isabel Cuesta, Rafael Sanchez Arroyo, Laura Alcazar-Fuoli, Emilia Mellado   +6 more
doaj   +1 more source

Engineering Yarrowia lipolytica for the biosynthesis of geraniol

Metabolic Engineering Communications, 2023
Geraniol is a monoterpene with wide applications in the food, cosmetics, and pharmaceutical industries. Microbial production has largely used model organisms lacking favorable properties for monoterpene production.
Ayushi Agrawal, Zhiliang Yang, Mark Blenner   +2 more
doaj   +1 more source

An approach to quantitate maternal transcripts localized in sea urchin egg cortex using RT-qPCR with accurate normalization.

PLoS ONE, 2022
The sea urchin egg cortex is a peripheral region of eggs comprising a cell membrane and adjacent cytoplasm, which contains actin and tubulin cytoskeleton, cortical granules and some proteins required for early development.
Yulia O Kipryushina, Mariia A Maiorova, Konstantin V Yakovlev   +2 more
doaj   +2 more sources

Recombinant HMG1 Protein Produced in Pichia pastoris: A Nonviral Gene Delivery Agent

BioTechniques, 1997
This paper describes the production of a recombinant protein from the expression system based on the methylotrophic yeast Pichia pastoris. Efficient production of rat high-mobility-group 1 (HMG1) protein was obtained using the system.
A.R. Mistry, L. Falciola, L. Monaco, R. Tagliabue, G. Acerbis, A. Knight, R.P. Harbottle, M. Soria, M.E. Bianchi, C. Coutelle, S.L. Hart   +10 more
doaj   +1 more source

Natural variation of MS2 confers male fertility and drives hybrid breeding in soybean

Plant Biotechnology Journal, Volume 21, Issue 11, Page 2322-2332, November 2023., 2023
Summary A complete and genetically stable male sterile line with high outcrossing rate is a prerequisite for the development of commercial hybrid soybean. It was reported in the last century that the soybean male sterile ms2 mutant has the highest record with seed set.
Xiaolong Fang, Xiangchi Feng, Xiaoyuan Sun, Xiangdong Yang, Qing Li, Xulei Yang, Jie Xu, Minghui Zhou, Chunjing Lin, Yi Sui, Limei Zhao, Baohui Liu, Fanjiang Kong, Chunbao Zhang, Meina Li   +14 more
wiley   +1 more source

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Emerging Infectious Diseases, 2018
The recent increase in azole-resistant Aspergillus fumigatus is a global concern. Identifying the mutations that confer azole resistance is essential for developing novel methods for prompt diagnosis and effective drug treatment. We screened A. fumigatus
Daisuke Hagiwara, Teppei Arai, Hiroki Takahashi, Yoko Kusuya, Akira Watanabe, Katsuhiko Kamei   +5 more
doaj   +1 more source

Engineering the oleaginous yeast Yarrowia lipolytica to produce nutraceuticals: From metabolic design to industrial applications

Food Bioengineering, Volume 2, Issue 3, Page 187-199, September 2023., 2023
Yarrowia lipolytica possesses a transparent inherited background, relatively mature molecular manipulations, and controllable metabolic regulations, making it one of the most popular and extensively researched nonconventional yeasts. Its broad substrate spectrum and superior environmental tolerance make it attractive to develop as a microbial cell ...
Yang Gu, Xueyao Lu, Tongkang Liu, Yanjin Song, Ellie Sang, Shuran Ding, Long Liu, Feng Xue, Peng Xu   +8 more
wiley   +1 more source

Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus

mBio, 2019
Aspergillus fumigatus is the predominant pathogen of invasive aspergillosis, a disease state credited with over 200,000 life-threatening infections each year.
Jeffrey M. Rybak, Wenbo Ge, Nathan P. Wiederhold, Josie E. Parker, Steven L. Kelly, P. David Rogers, Jarrod R. Fortwendel   +6 more
doaj   +1 more source

ER‐to‐lysosome‐associated degradation in a nutshell: mammalian, yeast, and plant ER‐phagy as induced by misfolded proteins

FEBS Letters, Volume 597, Issue 15, Page 1928-1945, August 2023., 2023
Endoplasmic reticulum‐associated degradation (ERAD) pathways control the retrotranslocation of terminally misfolded proteins across the ER membrane for clearance by the cytoplasmic ubiquitin/proteasome system. ER‐to‐lysosome‐associated degradation (ERLAD) pathways remove ERAD‐resistant proteins that are segregated into ER subdomains and transported to ...
Mikhail Rudinskiy, Maurizio Molinari
wiley   +1 more source

Genome-Wide HMG Family Investigation and Its Role in Glycoalkaloid Accumulation in Wild Tuber-Bearing Solanum commersonii

Life, 2020
Steroidal glycoalkaloids (SGAs) are a class of nitrogen-containing glycosides occurring in several plant families and biosynthesized through a specific pathway. HMG-CoA reductase is the first enzyme of this pathway, and its transcription can be regulated
Clizia Villano, Vincenzo D’Amelia, Salvatore Esposito, Maria Grazia Adelfi, Felice Contaldi, Rosalia Ferracane, Paola Vitaglione, Riccardo Aversano, Domenico Carputo   +8 more
doaj   +1 more source