Results 1 to 10 of about 25,300,433 (384)
Luteolin attenuates PM2.5-induced inflammatory responses by augmenting HO-1 and JAK-STAT expression in murine alveolar macrophages [PDF]
Food and Agricultural Immunology, 2022 To explore the involved mechanisms and possible treatments of ambient PM2.5 exposure-induced lung inflammation, this work studied the activity of luteolin, a natural flavonoid which widely presents in many plant species, in murine alveolar macrophage MH ...
Wen-Che Hsieh +9 more
doaj +2 more sources
Protective Effects of Relaxin 2 (RLXH2) against Hypoxia-Induced Oxidative Damage and Cell Death via Activation of The Nrf2/HO-1 Signalling Pathway in Gastric Cancer Cells [PDF]
Cell Journal, 2023 Objective: This study aims to investigate the potential role of relaxin, a peptide hormone, in preventing cellulardeterioration and death in gastric carcinoma cells under hypoxic conditions.
Liguo Wang, Yi Zhou, Hui Lin, Kezhu Hou
doaj +3 more sources
HO-1/CO Maintains Intestinal Barrier Integrity through NF-κB/MLCK Pathway in Intestinal HO-1−/− Mice [PDF]
Oxidative Medicine and Cellular Longevity, 2021 Background Intestinal barrier injury is an important contributor to many diseases. We previously found that heme oxygenase-1 (HO-1) and carbon monoxide (CO) protect the intestinal barrier. This study is aimed at elucidating the molecular mechanisms of HO-
Zhenling Zhang +6 more
semanticscholar +3 more sources
HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis
Frontiers in Cell and Developmental Biology, 2021 Osteoporosis is a prevalent bone disorder characterized by bone mass reduction and deterioration of bone microarchitecture leading to bone fragility and fracture risk.
Xueman Zhou +12 more
doaj +2 more sources
The Nrf2-HO-1 system and inflammaging
Frontiers in ImmunologyNrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. Among the genes upregulated by Nrf2, heme oxygenase-1 (HO-1) has received significant attention, given that the products of HO-1 ...
Sinead A. O'Rourke +2 more
semanticscholar +4 more sources
Antimicrobial Stewardship & Healthcare Epidemiology, 2023 Objectives: At the onset of COVID-19, whenever SARS-CoV-2 was detected at Children’s Hospital 1 (CH1), the related department or building was closed for extensive tracing, testing, and medical isolation.
Chau Nguyen Ngoc Minh +5 more
doaj +1 more source
Cell Death and Disease, 2021 Cetuximab is approved for the treatment of metastatic colorectal cancer (mCRC) with RAS wild-type. Nevertheless, the prognosis remains poor and the effectiveness of cetuximab is limited in KRAS mutant mCRC.
Jiawen Yang +7 more
semanticscholar +1 more source
The American Journal of Chinese Medicine, 2023 Diabetic nephropathy (DN) is thought to be the major cause of end-stage renal disease. Due to its complicated pathogenesis and the low efficacy of DN treatment, a deep understanding of new etiological factors may be useful.
Q. Feng +11 more
semanticscholar +1 more source
Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
Journal of Clinical Medicine, 2022 Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades.
Atena Mansouri +6 more
semanticscholar +1 more source
Journal of Veterinary Research, 2023 Penconazole (PEN) is a widely applied triazole fungicide. This study sought to define the efficacy of N-acetyl-l-cysteine (NAC) in mitigating PEN-triggered hepatorenal toxicity in rats.
Morgan Ashraf M. +10 more
doaj +1 more source