Results 1 to 10 of about 385,992 (148)
Antimicrobial Stewardship & Healthcare Epidemiology, 2023 Objectives: At the onset of COVID-19, whenever SARS-CoV-2 was detected at Children’s Hospital 1 (CH1), the related department or building was closed for extensive tracing, testing, and medical isolation.
Chau Nguyen Ngoc Minh +5 more
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HO‐1/CO Maintains Intestinal Barrier Integrity through NF‐κB/MLCK Pathway in Intestinal HO‐1-/- Mice [PDF]
Oxidative Medicine and Cellular Longevity, 2021 Background. Intestinal barrier injury is an important contributor to many diseases. We previously found that heme oxygenase‐1 (HO‐1) and carbon monoxide (CO) protect the intestinal barrier. This study is aimed at elucidating the molecular mechanisms of HO‐1/CO in barrier loss. Materials and Methods.
Zhenling Zhang +6 more
openaire +2 more sources
Journal of Veterinary Research, 2023 Penconazole (PEN) is a widely applied triazole fungicide. This study sought to define the efficacy of N-acetyl-l-cysteine (NAC) in mitigating PEN-triggered hepatorenal toxicity in rats.
Morgan Ashraf M. +10 more
doaj +1 more source
Protective Effects of Relaxin 2 (RLXH2) against Hypoxia-Induced Oxidative Damage and Cell Death via Activation of The Nrf2/HO-1 Signalling Pathway in Gastric Cancer Cells [PDF]
Cell Journal, 2023 Objective: This study aims to investigate the potential role of relaxin, a peptide hormone, in preventing cellulardeterioration and death in gastric carcinoma cells under hypoxic conditions.
Liguo Wang, Yi Zhou, Hui Lin, Kezhu Hou
doaj +1 more source
Role of heme oxygenase-1 in tumor immune escape
Redox Experimental Medicine, 2023 The inducible enzyme heme oxygenase 1 (HO-1) plays a pivotal role in cell defense against different kind of stressors, from oxidative stress to hypoxia. For this reason, HO-1 overexpression has been correlated to cancer aggressiveness in different tumors,
Mariapaola Nitti +2 more
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HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis
Frontiers in Cell and Developmental Biology, 2021 Osteoporosis is a prevalent bone disorder characterized by bone mass reduction and deterioration of bone microarchitecture leading to bone fragility and fracture risk.
Xueman Zhou +12 more
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Renal Failure, 2021 Aim Podocyte injury plays an important role in diabetic nephropathy (DN), yet the underlying molecular mechanisms of podocyte injury in DN is not clear.
Shizhu Yuan +5 more
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Antioxidants, 2020 Heme oxygenase-1 (HO-1) has several important roles in hepatocytes in terms of anti-inflammation, anti-apoptosis, and antioxidant properties. Interleukin-6 (IL-6) is a pleiotropic cytokine associated with liver regeneration and protection against injury.
Kun-Chun Chiang +6 more
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Distinct Approaches of Raloxifene: Its Far-Reaching Beneficial Effects Implicating the HO-System
Biomolecules, 2020 Selective estrogen receptor modulators (SERMs) were discovered in the mid-1900s in connection with estrogen-related pathological conditions. They were developed to antagonize the adverse effects of estrogen and have been shown to be effective against ...
Denise Börzsei +9 more
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Effect of vanillic acid on pentylenetetrazole-kindled rats: Nrf2/HO-1, IGF-1 signaling pathways cross talk [PDF]
Journal of Integrative Neuroscience, 2022 Vanillic acid (VA) exhibited antioxidant and neuroprotective properties in some neurodegenerative disorders. So, the current study examined the neuroprotective potential of VA as an antiepileptic agent in pentylenetetrazole (PTZ)-induced epileptic ...
Mahmoud A. El-Hefnawy +7 more
doaj +1 more source