Results 11 to 20 of about 456,511 (292)

Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression. [PDF]

, 2016
Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is a cytoprotective enzyme upregulated in the vasculature by increased flow and inflammatory stimuli.
Azuma, Junya, Dalman, Ronald L, Deng, Alicia C, Hsu, Mark, Kalish, Flora, Kayama, Yosuke, Maegdefessel, Lars, Morisawa, Takeshi, Spin, Joshua M, Stevenson, David K, Tsao, Philip S, Wallenstein, Matthew B, Wong, Ronald J, Zhao, Hui   +13 more
core   +15 more sources

Cerevisterol Alleviates Inflammation via Suppression of MAPK/NF-κB/AP-1 and Activation of the Nrf2/HO-1 Signaling Cascade

Biomolecules, 2020
As part of our continuous effort to find potential anti-inflammatory agents from endophytic fungi, a Fusarium solani strain, isolated from the plant Aponogeton undulatus Roxb., was investigated. Cerevisterol (CRVS) was identified from endophytic fungi, a
Md Badrul Alam, Nargis Sultana Chowdhury, Md Hossain Sohrab, Md Sohel Rana, Choudhury Mahmood Hasan, Sang-Han Lee   +5 more
doaj   +1 more source

Clinically confirmed DEL-1 as a myokine attenuates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocytes via AMPK/HO-1- pathway

Adipocyte, 2020
Regular exercise is the first line of therapy for treating obesity-mediated metabolic disorders, including insulin resistance. It has been reported that developmental endothelial locus-1 (DEL-1) enhances macrophage efferocytosis, resulting in ...
Chang Hyuk Kwon, Jaw Long Sun, Myeong Jun Kim, A. M. Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung   +5 more
doaj   +1 more source

Humanized HO-1 BAC transgenic mice: a new model for the study of HO-1 gene regulation [PDF]

Kidney International, 2012
Heme oxygenase-1 (HO-1) is a ubiquitous inducible stress-response enzyme that plays a central role in tissue homeostasis, in protection against oxidative stress, and in the pathogenesis of disease. Kim et al. report a novel transgenic mouse that lacks the endogenous HO-1 gene but contains the human HO-1 gene with all its regulatory elements.
Salom, Miguel G., Bonacasa, Bárbara
openaire   +2 more sources

Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress [PDF]

, 2018
Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity.We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO- 1)
Abraham, Nader G., Bamshad, David, Bellner, Lars, Favero, Gaia, Grant, Ilana, Lebovics, Edward, Meissner, Aliza, Raffaele, Marco, Rezzani, Rita, Rodella, Luigi F., Sacerdoti, David, Schragenheim, Joseph, Singh, Shailendra P., Vanella, Luca   +13 more
core   +1 more source

Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function [PDF]

, 2015
Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO ...
Cassidy, Aedin, Czank, Charles, Edwards, Michael, Kay, Colin, Woodward, Gary   +4 more
core   +1 more source

Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury

Translational Neuroscience, 2022
Spinal cord injury (SCI) is a severe central nervous system disease, which may cause serious locomotor deficit. Acacetin is a flavone that possesses antioxidant and anti-inflammatory effects in different human diseases. The main purpose of this study was
Zhang Xin, Xu Lijun, Chen Xiang, Zhou Xianjie, Cao Lanhua   +4 more
doaj   +1 more source

Study protocol: The clinical features, epidemiology, and causes of paediatric encephalitis in southern Vietnam [version 3; peer review: 2 approved]

Wellcome Open Research, 2022
Encephalitis is a major cause of morbidity and mortality worldwide. The clinical syndrome of encephalitis consists of altered mental status, seizures, neurologic signs, and is often accompanied by fever, headache, nausea, and vomiting.
Ngo Ngoc Quang Minh, Le Nguyen Thanh Nhan, Louise Thwaites, Hugo Turner, Nguyen Thanh Hung, Sarosh Irani, Le Van Tan, Nguyen Hoang Thien Huong, Du Tuan Quy, Nguyen Duc Toan, Le Quoc Thinh, Truong Huu Khanh   +11 more
doaj   +1 more source

EETs and HO-1 cross-talk

Prostaglandins & Other Lipid Mediators, 2016
Epoxygenase-dependent metabolites of arachidonc acid, EETs and the heme-oxygenase (HO)-1/carbon monoxide/bilverdin system share similarities in their activity and mediators. They control endothelial function, dilating small arterial vessels, decrease blood pressure, protect the heart from ischemic and hypertensive cardiopathy, control renal circulation
SACERDOTI, DAVID, PESCE, PAOLA, DI PASCOLI, MARCO, BOLOGNESI, MASSIMO   +3 more
openaire   +2 more sources

Nuclear Factor-κB-Independent Anti-Inflammatory Action of Salicylate in Human Endothelial Cells [PDF]

, 2006
In contrast to aspirin, salicylate, its active metabolite, possesses profound anti-inflammatory properties without blocking cyclooxygenase. Inhibition of the transcription factor nuclear factor-κB (NF-κB) has been discussed to play a role in the anti ...
Blumenthal, Signe B., Fürst, Robert, Kiemer, Alexandra K., Vollmar, Angelika M., Zahler, Stefan   +4 more
core   +1 more source