Results 11 to 20 of about 25,300,433 (384)
Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression. [PDF]
, 2016 Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is a cytoprotective enzyme upregulated in the vasculature by increased flow and inflammatory stimuli.
Azuma, Junya +13 more
core +18 more sources
Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway [PDF]
, 2016 Circulating levels of chylomicron remnants (CMRs) increase postprandially and their composition directly reflects dietary lipid intake. These TG-rich lipoproteins likely contribute to the development of endothelial dysfunction, albeit via unknown ...
Sally H. Latham Birt +3 more
openalex +4 more sources
PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis [PDF]
, 2015 Aims Vascular injury leading to endothelial dysfunction is a characteristic feature of chronic renal disease, diabetes mellitus, and systemic inflammatory conditions, and predisposes to apoptosis and atherogenesis.
Hayley Mylroie +12 more
openalex +4 more sources
Oxidative Medicine and Cellular Longevity, 2022 Background. Diabetes mellitus (DM) can induce cardiomyocyte injury and lead to diabetic cardiomyopathy (DCM) which presently has no specific treatments and consequently increase risk of mortality. Objective.
Sheng-fa Wu +7 more
semanticscholar +1 more source
Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice
Frontiers in Endocrinology, 2021 Background Ferroptosis is a recently identified iron-dependent form of cell death as a result of increased reactive oxygen species (ROS) and lipid peroxidation.
Xiaomeng Feng +6 more
semanticscholar +1 more source
Role of heme oxygenase-1 in tumor immune escape
Redox Experimental Medicine, 2023 The inducible enzyme heme oxygenase 1 (HO-1) plays a pivotal role in cell defense against different kind of stressors, from oxidative stress to hypoxia. For this reason, HO-1 overexpression has been correlated to cancer aggressiveness in different tumors,
Mariapaola Nitti +2 more
doaj +1 more source
The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival
Cells, 2021 Heme oxygenases (HOs) act on heme degradation to produce carbon monoxide (CO), free iron, ferritin, and biliverdin. Upregulation of cellular HO-1 levels is signature of oxidative stress for its downstream effects particularly under pro-oxidative status ...
Shih-Kai Chiang +2 more
semanticscholar +1 more source
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
Journal of Neuroinflammation, 2021 Background The inflammation and oxidative stress (OS) have been considered crucial components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger, processes strong biological activities including antioxidant, anti-inflammatory ...
Ruozhi Dang +10 more
semanticscholar +1 more source
Renal Failure, 2021 Aim Podocyte injury plays an important role in diabetic nephropathy (DN), yet the underlying molecular mechanisms of podocyte injury in DN is not clear.
Shizhu Yuan +5 more
doaj +1 more source
Wellcome Open Research, 2022 Encephalitis is a major cause of morbidity and mortality worldwide. The clinical syndrome of encephalitis consists of altered mental status, seizures, neurologic signs, and is often accompanied by fever, headache, nausea, and vomiting.
Ngo Ngoc Quang Minh +11 more
doaj +1 more source