Results 21 to 30 of about 25,300,433 (384)

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

Journal of Translational Medicine, 2021
Background Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induces uncontrolled and self-amplified pulmonary inflammation, and has high morbidity and mortality rates in critically ill patients.
Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, W. Sheng, Wanming Hao, Min Liu, Weihong Lv, W. Han   +9 more
semanticscholar   +1 more source

Intermittent fasting reduces neuroinflammation in intracerebral hemorrhage through the Sirt3/Nrf2/HO-1 pathway

Journal of Neuroinflammation, 2021
Inflammation contributes to the poor prognosis of intracerebral hemorrhage (ICH). Intermittent fasting (IF) has been shown to be protective against inflammation in multiple pathogenic processes.
Shuhui Dai, Jialiang Wei, Hongchen Zhang, P. Luo, Yue-fan Yang, Xiaofan Jiang, Z. Fei, Wenbin Liang, Jianli Jiang, Xia Li   +9 more
semanticscholar   +1 more source

Human Heme Oxygenase-1 Induced by Interleukin-6 via JAK/STAT3 Pathways Is a Tumor Suppressor Gene in Hepatoma Cells

Antioxidants, 2020
Heme oxygenase-1 (HO-1) has several important roles in hepatocytes in terms of anti-inflammation, anti-apoptosis, and antioxidant properties. Interleukin-6 (IL-6) is a pleiotropic cytokine associated with liver regeneration and protection against injury.
Kun-Chun Chiang, Kang-Shuo Chang, Shu-Yuan Hsu, Hsin-Ching Sung, Tsui-Hsia Feng, Mei Chao, Horng-Heng Juang   +6 more
doaj   +1 more source

Icariin inhibits hypoxia/reoxygenation‐induced ferroptosis of cardiomyocytes via regulation of the Nrf2/HO‐1 signaling pathway

FEBS Open Bio, 2021
Myocardial infarction (MI) is caused by the formation of plaques in the arterial walls, leading to a decrease of blood flow to the heart and myocardium injury as a result of hypoxia.
Xiu-juan Liu, Yangjun Lv, Wenwen Cui, Yan Li, Yang Liu, Yi-Tao Xue, Feng Dong   +6 more
semanticscholar   +1 more source

Distinct Approaches of Raloxifene: Its Far-Reaching Beneficial Effects Implicating the HO-System

Biomolecules, 2020
Selective estrogen receptor modulators (SERMs) were discovered in the mid-1900s in connection with estrogen-related pathological conditions. They were developed to antagonize the adverse effects of estrogen and have been shown to be effective against ...
Denise Börzsei, Renáta Szabó, Alexandra Hoffmann, Médea Veszelka, Imre Pávó, Zsolt Turcsán, Csaba Viczián, Krisztina Kupai, Csaba Varga, Anikó Pósa   +9 more
doaj   +1 more source

Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease

Frontiers in Pharmacology, 2021
Parkinson’s disease (PD) is a complex neurodegenerative disorder featuring both motor and nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Oxidative stress (OS) has been implicated in the
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du   +7 more
semanticscholar   +1 more source

Cerevisterol Alleviates Inflammation via Suppression of MAPK/NF-κB/AP-1 and Activation of the Nrf2/HO-1 Signaling Cascade

Biomolecules, 2020
As part of our continuous effort to find potential anti-inflammatory agents from endophytic fungi, a Fusarium solani strain, isolated from the plant Aponogeton undulatus Roxb., was investigated. Cerevisterol (CRVS) was identified from endophytic fungi, a
Md Badrul Alam, Nargis Sultana Chowdhury, Md Hossain Sohrab, Md Sohel Rana, Choudhury Mahmood Hasan, Sang-Han Lee   +5 more
doaj   +1 more source

Effect of vanillic acid on pentylenetetrazole-kindled rats: Nrf2/HO-1, IGF-1 signaling pathways cross talk [PDF]

Journal of Integrative Neuroscience, 2022
Vanillic acid (VA) exhibited antioxidant and neuroprotective properties in some neurodegenerative disorders. So, the current study examined the neuroprotective potential of VA as an antiepileptic agent in pentylenetetrazole (PTZ)-induced epileptic ...
Mahmoud A. El-Hefnawy, Asmaa Yehia, Eman M. El Nashar, Somaya Saad, Walaa Obydah, Mansour A. Alghamdi, Wardah A. Alasmari, Abdelaziz M. Hussein   +7 more
doaj   +1 more source

Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1

Aging, 2020
Acute lung injury (ALI) is a syndrome associated with a high mortality rate. Nrf2 is a key regulator of intracellular oxidation homeostasis that plays a pivotal role in controlling lipid peroxidation, which is closely related to the process of ...
H. Dong, Zhuanzhuan Qiang, Dongdong Chai, Jiali Peng, Yangyang Xia, Rong Hu, Hong Jiang   +6 more
semanticscholar   +1 more source

Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells

International Journal on Biological Sciences, 2021
Rationale: Colorectal cancer (CRC) is a common malignant tumor of the digestive system. However, the efficacy of surgery and chemotherapy is limited. Ferroptosis is an iron- and reactive oxygen species (ROS)-dependent form of regulated cell death (RCD ...
R. Wei, Yueqin Zhao, Juan Wang, Xu Yang, Shun-Lin Li, Yinyuan Wang, Xingzhi Yang, Jimin Fei, Xiaojiang Hao, Yuhan Zhao, Liming Gui, Xiao Ding   +11 more
semanticscholar   +1 more source