Results 51 to 60 of about 25,300,433 (384)

Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels [PDF]

, 2014
Induction of the antioxidant enzyme heme oxygenase-1 (HO-1) affords cellular protection and suppresses proliferation of vascular smooth muscle cells (VSMCs) associated with a variety of pathological cardiovascular conditions including myocardial ...
A Panner, B Kumar, B Ramlawi, BC Van, BH Tzeng, BR Wamhoff, BW Kimes, Chris Peers, DJ Beech, DM Rodman, E Perez-Reyes, E VanBavel, Emily Johnson, F Gackiere, F Pluteanu, Francesca Giuntini, GK Owens, GK Owens, Hannah E. Boycott, Hayley Duckles, HE Boycott, HP Kim, J Cao, J Chemin, JA Araujo, Jacobo Elies, Jason L. Scragg, JF Quignard, JH Heo, JH Jaggar, JH Lee, JL Scragg, John P. Boyle, Karen E. Porter, L Huang, L Lipskaia, LE Otterbein, LI Brueggemann, LL Cribbs, LS Gray, M Barbado, M Gollasch, Mark L. Dallas, ML Dallas, Moza M. Al-Owais, MT Nelson, PM Vanhoutte, R Foresti, R Motterlini, R Schmitt, S Kourembanas, S Richard, SE Williams, SF Yet, SH Vitali, SJ House, SW Ryter, T Chang, T Kuga, T Minamino, TB Bolton, TN Marks, W Durante, W Durante, W Zhang, WF Jackson, Z Xiong   +66 more
core   +2 more sources

The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases

Cardiology Research and Practice, 2020
Cardiovascular disease, which can lead to angina and shortness of breath, remains one of the most serious threats to human health. Owing to its imperceptible symptoms, it is difficult to determine the pathogenesis and treatment methods for cardiovascular
Xueyan Zhang, Yihan Yu, Han-Yu Lei, Yufeng Cai, Jie Shen, P. Zhu, Qingnan He, Mingyi Zhao   +7 more
semanticscholar   +1 more source

Metalloporphyrins inactivate caspase-3 and -8 [PDF]

, 2005
Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in ...
Blumenthal, Signe B., Brandt, Birte, Höltje, Hans-Dieter, Höltje, Monika, Kiemer, Alexandra K., Seyfried, Stefan, Tiegs, Gisa, Vollmar, Angelika M., Zahler, Stefan   +8 more
core   +1 more source

HIF‐1α ameliorates tubular injury in diabetic nephropathy via HO‐1–mediated control of mitochondrial dynamics

Cell Proliferation, 2020
In diabetic nephropathy (DN), hypoxia‐inducible factor‐1α (HIF‐1α) activation in tubular cells plays an important protective role against kidney injury. The effects may occur via the target genes of HIF‐1α, such as haem oxygenase‐1 (HO‐1), but the exact ...
Na Jiang, Hao Zhao, Yachun Han, Li Li, Shan Xiong, L. Zeng, Ying Xiao, Ling Wei, Xiao-fen Xiong, Peng Gao, Ming Yang, Yu Liu, Lin Sun   +12 more
semanticscholar   +1 more source

Effects of Losartan, HO-1 Inducers or HO-1 Inhibitors on Erectile Signaling in Diabetic Rats

The Journal of Sexual Medicine, 2009
ABSTRACT Introduction Activation of the renin-angiotensin system which is common in diabetes mellitus might affect heme oxygenase (HO-1) gene expression. Aim Assessment of the effects of administration of angiotensin II (Ang II ...
Mohamed Talaat, Abdel Aziz, Mohamed Farid, El Asmer, Taymour, Mostafa, Hazem, Atta, Soheir, Mahfouz, Hanan, Fouad, Laila, Rashed, Dina, Sabry, Amira, Hassouna, Ahmed Talaat, Abdel Aziz, Amira, Senbel, Ahmed, Demery   +11 more
openaire   +2 more sources

Induction of heme-oxygenase-1 (HO-1) does not enhance adiponectin production in human adipocytes: evidence against a direct HO-1 - Adiponectin axis [PDF]

, 2015
Adiponectin is a salutary adipokine and hypoadiponectinemia is implicated in the aetiology of obesity-related inflammation and cardiometabolic disease making therapeutic strategies to increase adiponectin attractive. Emerging evidence, predominantly from
Barclay, Johanna L., He, Jingjing, Keshvari, Sahar, Kimura, Masaki, Ng, Choaping, Rose, Felicity J., Whitehead, Jonathan P., Yang, Mengliu   +7 more
core   +1 more source

Leukemia Inhibitory Factor Attenuates Hypoxic–Ischemic White Matter Injury via NLRP3 Inflammasome Activity Suppressing Through the Nrf2/HO-1 Pathway

Frontiers in Bioscience-Landmark
Background: Inhibiting neuroinflammatory damage is an effective strategy for treating preterm white matter injury (PWMI). Leukemia inhibitory factor (LIF) can ameliorate (HI) induced white matter injury; however, the neuroprotective ...
Liang Huo, Xueyan Liu, Hua Wang
doaj   +1 more source

Mechanism of Action and Therapeutic Implications of Nrf2/HO-1 in Inflammatory Bowel Disease

Antioxidants
Oxidative stress (OS) is a key factor in the generation of various pathophysiological conditions. Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a major transcriptional regulator of antioxidant reactions.
Lingling Yuan, Yingyi Wang, Na Li, Xuli Yang, Xuhui Sun, Huai’e Tian, Yi Zhang   +6 more
semanticscholar   +1 more source

Intragraft heme oxygenase-1 and coronary artery disease after heart transplantation [PDF]

, 2004
Peri-operative tissue injury triggers the development of Transplant Coronary Artery Disease (TCAD). Animal studies have shown that induction of heme oxygenase (HO)-1 protects the donor organ from the development of TCAD.
Baan, C.C. (Carla), Balk, A.H.M.M. (Aggie), Engel, S. (Sandra) van den, Holweg, C.T.J. (Cécile), Maat, A.W.P.M. (Alex), Niesters, H.G.M. (Bert), Snaathorst, J. (Jasper), Weimar, W. (Willem), Zondervan, P.E. (Pieter)   +8 more
core   +1 more source

Heme oxygenase 1 improves glucoses metabolism and kidney histological alterations in diabetic rats [PDF]

, 2013
One important concern in the treatment of diabetes is the maintenance of glycemic levels and the prevention of diabetic nephropathy. Inducible heme oxygenase 1 (HO-1) is a rate-limiting enzyme thought to have antioxidant and cytoprotective roles.
Albertoni, Guilherme A., Borges, Fernanda T., Convento, Marcia B., Fernandes, Gabryelle S., Pessoa, Edson A., Ptilovanciv, Ellen O. N., Reis, Luciana A., Schor, Nestor, Simoes, Manuel J., Teixeira, Luciana C.   +9 more
core   +1 more source