Results 41 to 50 of about 6,534 (190)
Topological dynamics of holins in programmed bacterial lysis [PDF]
Proceedings of the National Academy of Sciences, 2006 The fate of phage-infected bacteria is determined by the holin, a small membrane protein that triggers to disrupt the membrane at a programmed time, allowing a lysozyme to attack the cell wall. S 21 68, the holin of phage 21, has two transmembrane domains (TMDs) with a predicted N-in, C-in ...
Taehyun, Park +3 more
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A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens [PDF]
, 2014 Pathogenic bacteria adapt to their environment and manipulate the biochemistry of hosts by secretion of effector molecules. Serratia marcescens is an opportunistic pathogen associated with healthcare-acquired infections and is a prolific secretor of ...
Guo, Manman +23 more
core +1 more source
Functional Analysis of the Endopeptidase and Holin From Planktothrix agardhii Cyanophage PaV-LD
Frontiers in Microbiology, 2022 A cyanophage PaV-LD, previously isolated from harmful filamentous cyanobacterium Planktothrix agardhii, was sequenced, and co-expression of its two ORFs in tandem, ORF123 and ORF124, inhibited growth on the model cyanobacterium Synechocystis sp.
Li-Hui Meng +5 more
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Oligohistidine Tag Mutagenesis of the λ Holin Gene [PDF]
Journal of Bacteriology, 1998 ABSTRACT Holins are a diverse group of small integral membrane proteins elaborated by bacteriophages to lyse bacterial hosts and effect release of progeny phages in a precisely timed manner. Recently, the holin S gene of phage λ was overexpressed and the holin protein was purified to homogeneity by means ...
D L, Smith, R, Young
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mBio, 2022 The Staphylococcus aureus cidABC and lrgAB operons encode members of a well-conserved family of proteins thought to be involved in programmed cell death (PCD).
Jennifer L. Endres +9 more
doaj +1 more source
An Optimal Lysis Time Maximizes Bacteriophage Fitness in Quasi-Continuous Culture
mBio, 2022 Optimality models have a checkered history in evolutionary biology. While optimality models have been successful in providing valuable insight into the evolution of a wide variety of biological traits, a common objection is that optimality models are ...
Sherin Kannoly +2 more
doaj +1 more source
Molecular mechanism of holin transmembrane domain I in pore formation and bacterial cell death
, 2015 Bacterial cell lysis during bacteriophage infection is timed by perfect orchestration between components of the holin-endolysin cassette. In bacteria, progressively accumulating holin in the inner membrane, retained in its inactive form by antiholin, is ...
Kamilla, Soumya +3 more
core +2 more sources
Reconstitution of Holin Activity with a Synthetic Peptide Containing the 1–32 Sequence Region of EJh, the EJ-1 Phage Holin [PDF]
Journal of Biological Chemistry, 2003 Pneumococcal EJ-1 phage holin (EJh) is a hydrophobic polypeptide of 85 amino acid residues displaying lethal inner membrane disruption activity. To get an insight into holin structure and function, several peptides representing the different topological regions predicted by sequence analysis have been synthesized.
Haro, Amparo +6 more
openaire +3 more sources
Raportti Holin kevätseminaarista 2019
Ennen ja Nyt: Historian Tietosanomat, 2019 Otto Hormio
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Endolysin Regulation in Phage Mu Lysis
mBio, 2022 Bacteriophage Mu is a paradigm coliphage studied mainly because of its use of transposition for genome replication. However, in extensive nonsense mutant screens, only one lysis gene has been identified, the endolysin gp22.
Jake S. Chamblee +7 more
doaj +1 more source