A Cytoplasmic Antiholin Is Embedded In Frame with the Holin in a Lactobacillus fermentum Bacteriophage [PDF]
Applied and Environmental Microbiology, 2018 ABSTRACT In double-stranded DNA bacteriophages, infection cycles are ended by host cell lysis through the action of phage-encoded endolysins and holins. The precise timing of lysis is regulated by the holin inhibitors, named antiholins.
Tingting, Guo +3 more
openaire +3 more sources
From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions [PDF]
mBio, 2017 Programmed cell death in bacteria is generally triggered by membrane proteins with functions analogous to those of bacteriophage holins: they disrupt the membrane potential, whereas antiholins antagonize this process.
Marielle H. van den Esker +2 more
doaj +2 more sources
Characterization of a lytic Pseudomonas aeruginosa phage vB_PaeP_ASP23 and functional analysis of its lysin LysASP and holin HolASP [PDF]
Frontiers in Microbiology, 2023 In this study, we isolated a lytic Pseudomonas aeruginosa phage (vB_PaeP_ASP23) from the sewage of a mink farm, characterized its complete genome and analyzed the function of its putative lysin and holin.
Jiaqi Cui +11 more
doaj +2 more sources
Characterization of holins, the membrane proteins of coliphage ASEC2201: a genomewide in silico approach [PDF]
Frontiers in MicrobiologyDrug-resistant Escherichia coli poses a significant healthcare burden, driving the search for novel antimicrobials. We have previously done the isolation and whole-genome sequencing of ASEC2201, a novel coliphage derived from multidrug-resistant clinical
Humaira Saeed +7 more
doaj +2 more sources
Pepholin, a bacteriophage holin-derived antimicrobial peptide with membrane-disruptive activity and therapeutic efficacy in MDR Pseudomonas aeruginosa burn wounds [PDF]
RSC AdvancesThe emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa poses a serious threat to burn wound healing, necessitating the development of alternative therapeutics beyond conventional antibiotics.
Purushotham RV +8 more
doaj +2 more sources
External factors influence intrinsic differences in Stx2e production by Porcine Shiga Toxin-producing Escherichia coli strains. [PDF]
PLoS PathogensPorcine Shiga toxin-producing Escherichia coli (STEC) strains pose significant challenges to the pig industry. The toxins produced by these strains, particularly Shiga toxin subtype 2e (Stx2e), are associated with a range of clinical symptoms such as ...
Sander Van Hoorde +7 more
doaj +2 more sources
Al-Holin suomalaislapset eduskunnan täysistuntopuheenvuoroissa
, 2020 unknown ...
Sämpi, Julia
core +3 more sources
Dimerization between the Holin and Holin Inhibitor of Phage λ [PDF]
Journal of Bacteriology, 2000 ABSTRACT Holins are integral membrane proteins that control the access of phage-encoded muralytic enzymes, or endolysins, to the cell wall by the sudden formation of an uncharacterized homo-oligomeric lesion, or hole, in the membrane, at a precisely defined time. The timing of λ-infected cell lysis depends solely on the 107 codon
Gründling, Angelika +3 more
openaire +3 more sources
SUPER: Upcycling Genetic Parts for Precise Gene Expression Control, Leakage Minimization, and Genetic Circuit Stability. [PDF]
Adv Sci (Weinh)To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Heo T, Park D, Shin W, Kim J.
europepmc +2 more sources
ESC Heart Failure, 2022 Objective As a common complication of coronary microembolization (CME), myocardial injury (MI) implies high mortality. Long non‐coding RNAs (lncRNAs) are rarely studied in CME‐induced MI.
Liying Xuan +5 more
doaj +1 more source