Results 11 to 20 of about 6,534 (190)
Spatial and temporal control of lysis by the lambda holin
mBio, 2023 The infection cycle of phage λ terminates in lysis mediated by three types of lysis proteins, each disrupting a layer in the bacterial envelope: the S105 holin, the R endolysin, and the Rz/Rz1 spanin complex targeting the inner membrane, cell wall or ...
Jesse Cahill +8 more
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Clostridioides difficile’s virulence requires efficient holin-mediated toxin secretion [PDF]
iScienceSummary: The human pathogen Clostridioides difficile causes pseudomembranous colitis through release of the potent TcdA and TcdB toxins. These toxins lack canonical N-terminal secretion signal sequences for translocation across the bacterial membrane ...
Nicholas V. DiBenedetto +7 more
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The Holin-Endolysin Lysis System of the OP2-Like Phage X2 Infecting Xanthomonas oryzae pv. oryzae
Viruses, 2021 Most endolysins of dsDNA phages are exported by a holin-dependent mechanism, while in some cases endolysins are exported via a holin-independent mechanism.
Zhifeng Wu +9 more
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Occurrence and potential mechanism of holin-mediated non-lytic protein translocation in bacteria [PDF]
Microbial Cell, 2022 Holins are generally believed to generate large membrane lesions that permit the passage of endolysins across the cytoplasmic membrane of prokaryotes, ultimately resulting in cell wall degradation and cell lysis. However, there are more and more examples
Thomas Brüser, Denise Mehner-Breitfeld
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Secretion of Clostridium difficile toxins A and B requires the holin-like protein TcdE. [PDF]
PLoS Pathogens, 2012 The pathogenesis of Clostridium difficile, the major cause of antibiotic-associated diarrhea, is mainly associated with the production and activities of two major toxins.
Revathi Govind, Bruno Dupuy
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Holin triggering in real time [PDF]
Proceedings of the National Academy of Sciences, 2010 During λ infections, the holin S105 accumulates harmlessly in the membrane until, at an allele-specific time, suddenly triggering to form irregular holes of unprecedented size (>300 nm), releasing the endolysin from the cytoplasm, resulting in lysis within seconds.
Rebecca, White +7 more
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Toxins, 2022 Protein secretion is generally mediated by a series of distinct pathways in bacteria. Recently, evidence of a novel bacterial secretion pathway involving a bacteriophage-related protein has emerged.
Callum J. Vidor +6 more
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Deciphering the Role of Holin in Mycobacteriophage D29 Physiology [PDF]
Frontiers in Microbiology, 2020 In the era of antibiotic resistance, phage therapy is gaining attention for the treatment of pathogenic organisms such as Mycobacterium tuberculosis. The selection of phages for therapeutic purposes depends upon several factors such as the host range ...
Varun Rakeshbhai Bavda, Vikas Jain
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Functional Analysis of the Holin-Like Proteins of Mycobacteriophage Ms6 [PDF]
Journal of Bacteriology, 2011 ABSTRACT The mycobacteriophage Ms6 is a temperate double-stranded DNA (dsDNA) bacteriophage which, in addition to the predicted endolysin (LysA)-holin (Gp4) lysis system, encodes three additional proteins within its lysis module: Gp1, LysB, and Gp5. Ms6 Gp4 was previously described as a class II holin-like protein. By analysis of
Maria João, Catalão +3 more
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A dimeric holin/antiholin complex controls lysis by phage T4 [PDF]
Frontiers in MicrobiologyLytic phages control the timepoint of host cell lysis by timing the holin-mediated release of cell wall-degrading endolysins. In phage T4, the antiholin RI inhibits the holin T, thereby preventing the early release of the T4 endolysin and lysis.
Jan Michel Frederik Schwarzkopf +2 more
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