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Purification of the proline-rich homeodomain protein
Journal of Chromatography B, 2003The proline-rich homeodomain protein (PRH), also known as Hex, is a transcriptional repressor expressed in a variety of cell types. The PRH protein contains a proline-rich N-terminal domain that can repress transcription when attached to a heterologous DNA binding domain, a central homeodomain that mediates sequence-specific DNA binding, and an acidic ...
Butcher, AJ, Gaston, K, Jayaraman, P-S
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Homeodomain Proteins: Homeotic genes seek partners
Current Biology, 1994The interactions of one homeodomain protein with another may be a general way in which their specificity is enhanced.
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zhx-1:A Novel Mouse Homeodomain Protein Containing Two Zinc-Fingers and Five Homeodomains
Biochemical and Biophysical Research Communications, 1996A cDNA encoding the complete reading frame of a novel homeodomain-containing protein, named zhx-1, has been cloned from a mouse bone marrow stromal cell line. The ORF encodes a protein of 873 amino acids, in which two C2-H2 zinc-fingers and five homeodomains have been identified.
I, Barthelemy +5 more
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1998
Abstract As described in Chapter 3, homeodomain proteins are transcription factors that are characterized by the presence of a 60-amino-acid DNA binding domain. The structure of the homeodomain consists of a flexible amino-terminal arm followed by three a helices (Fig.
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Abstract As described in Chapter 3, homeodomain proteins are transcription factors that are characterized by the presence of a 60-amino-acid DNA binding domain. The structure of the homeodomain consists of a flexible amino-terminal arm followed by three a helices (Fig.
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Homeodomain Proteins in Pancreas Development
2001The pancreas derives from the upper, duodenal part of the foregut via a dorsal and ventral protrusion of the epithelium directly posterior to the developing stomach, and in the mouse, the early pancreatic buds become evident on embryonic day 9 (e9) (Figure 1). The part of the gut from which the pancreas originates becomes committed to a pancreatic fate
Ulf Ahlgren, Helena Edlund
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Intracellular Trafficking and Dynamics of Double Homeodomain Proteins
Biochemistry, 2005Double homeodomain (DUX) proteins are encoded by a family of 3.3-kilobase repeated elements dispersed in the human genome. One of these elements named D4Z4 is found in a tandem repeat array on chromosome 4 that is partially deleted in facioscapulohumeral muscular dystrophy.
Cecilia, Ostlund +3 more
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Regulation of TFF3 expression by homeodomain protein CDX2
Regulatory Peptides, 2007Although trefoil factor family 3 (TFF3) plays an important role in protecting the intestinal mucosa, the regulatory mechanisms of its expression are not fully understood. Since homeodomain protein CDX2 has been reported to be critically involved in the development and differentiation of intestinal epithelium, we examined whether CDX2 affects the ...
Tadahito, Shimada +4 more
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A class act: conservation of homeodomain protein functions
Development, 1994ABSTRACT Dramatic successes in identifying vertebrate homeobox genes closely related to their insect relatives have led to the recognition of classes within the homeodomain superfamily. To what extent are the homeodomain protein classes dedicated to specific functions during development?
J R, Manak, M P, Scott
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cAMP-Dependent Transactivation Involving the Homeodomain Protein Pbx1
Archives of Biochemistry and Biophysics, 1997Pbx1 is a DNA-binding homeodomain protein originally discovered in the t(1;19) chromosomal translocation associated with pediatric pre-B acute lymphoblastic leukemia. Previously we reported a cAMP-regulatory sequence (CRS1) in the promoter region of the bovine CYP17 gene encoding steroid 17alpha-hydroxylase cytochrome P450 (P450c17) to be the first ...
A, Ogo, M R, Waterman, N, Kagawa
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Expression of homeodomain protein CDX2 in gallbladder carcinomas
Journal of Cancer Research and Clinical Oncology, 2005Caudal-related homeobox protein CDX2 plays an important role in the regulation of cell proliferation and differentiation of the intestinal epithelium. CDX2 is associated with intestinal metaplasia and carcinomas of the stomach, but the role of CDX2 in gallbladder carcinogenesis remains unknown.We analyzed the expression of CDX2 and intestinal apomucin ...
Xiang-Song, Wu +9 more
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