The future of recombinant host defense peptides [PDF]
Microbial Cell Factories, 2022 The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities that are attractive for translational applications,
Ramon Roca-Pinilla +3 more
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The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production [PDF]
Journal of Animal Science and Biotechnology, 2022 Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial activities against infectious bacteria, viruses, and fungi. Increasing evidence suggests that HDPs can also indirectly protect hosts by modulating their immune responses ...
Di Wu +3 more
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The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production [PDF]
Veterinary Research, 2018 Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and ...
Albert van Dijk +3 more
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Bacterial-Specific Aggregation and Killing of Immunomodulatory Host Defense Peptides [PDF]
Pharmaceuticals, 2021 This study involves the design and development of disulfide bridge-linked antimicrobial peptides using the host defense protein Angiogenin 4 (chAng4) as a template.
Nauman Nazeer +2 more
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Host Defense Peptide-Mimicking Polymers and Polymeric-Brush-Tethered Host Defense Peptides: Recent Developments, Limitations, and Potential Success [PDF]
Pharmaceutics, 2021 Amphiphilic antimicrobial polymers have attracted considerable interest as structural mimics of host defense peptides (HDPs) that provide a broad spectrum of activity and do not induce bacterial-drug resistance.
Hashem Etayash, Robert E. W. Hancock
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Retro-inversion imparts antimycobacterial specificity to host defense peptides [PDF]
Nature CommunicationsAntimicrobial host defense peptides are promising alternatives to resistance prone small molecule antibiotics. To overcome the poor physiologic stability of these therapeutic candidates it is common to prepare proteolytically resistant retro-inverso ...
Hugh D. Glossop +8 more
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Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides [PDF]
mSphere, 2021 Antibiotic resistance is a pressing problem and estimated to be a leading cause of mortality by 2050. Antimicrobial peptides, also known as host defense peptides (HDPs), and HDP-derived antimicrobials have potent antimicrobial activity and high potential
Melanie D. Balhuizen +5 more
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Host Defense Peptides as Templates for Antifungal Drug Development [PDF]
Journal of Fungi, 2020 Current treatment for invasive fungal diseases is limited to three classes of antifungal drugs: azoles, polyenes, and echinocandins. The most recently introduced antifungal class, the echinocandins, was first approved nearly 30 years ago.
Virginia Basso +3 more
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Toward the Discovery of Host-Defense Peptides in Plants [PDF]
Frontiers in Immunology, 2020 Defense peptides protect multicellular eukaryotes from infections. In biomedical sciences, a dominant conceptual framework refers to defense peptides as host-defense peptides (HDPs), which are bifunctional peptides with both direct antimicrobial and ...
Benjamin Petre
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Host defense peptides in malaria infection: their contributions, significance and constraints [PDF]
Malaria JournalPlasmodium-induced malaria infection remains a leading global health threat. Host defense peptides (HDPs), key components of innate immunity, target multiple stages of Plasmodium development through direct antimicrobial activity and immunomodulation ...
Dia Aldeen Alfaki +1 more
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