The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria [PDF]
Frontiers in Immunology, 2020 Host defense peptides, abundantly secreted by colonic epithelial cells and leukocytes, are proposed to be critical components of an innate immune response in the colon against enteropathogenic bacteria, including Shigella spp., Salmonella spp ...
Graham A. D. Blyth +3 more
doaj +2 more sources
Evaluating Host Defense Peptides: A Comparative Analysis of Synthetic Peptides and Recombinant Concatemers [PDF]
BiomoleculesThe global antibiotic resistance crisis raises concerns about antibiotic use, and alternative strategies are urgently needed. In this context, host defense peptides (HDPs) have rapidly gained interest.
Cristina Saubi +6 more
doaj +2 more sources
Crosstalk Between Intestinal Microbiota and Host Defense Peptides in Fish [PDF]
BiologyThe intricate crosstalk between intestinal microbiota and host defense peptides (HDPs) in aquaculture has emerged as a cornerstone for advancing sustainable disease management and reducing reliance on antibiotics. This review synthesizes current insights
Xiao-Zheng Yu, Yang Yu, Zi-Yan Liu
doaj +2 more sources
Strategies in Translating the Therapeutic Potentials of Host Defense Peptides [PDF]
Frontiers in Immunology, 2020 The golden era of antibiotics, heralded by the discovery of penicillin, has long been challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides (HDPs), previously known as antimicrobial peptides, are emerging as a group of ...
Darren Shu Jeng Ting +7 more
doaj +2 more sources
Cathelicidin Host Defense Peptides and Inflammatory Signaling: Striking a Balance [PDF]
Frontiers in Microbiology, 2020 Host-defense peptides (HDPs) are vital components of innate immunity in all vertebrates. While their antibacterial activity toward bacterial cells was the original focus for research, their ability to modulate immune and inflammatory processes has ...
Morgan A. Alford +5 more
doaj +2 more sources
Functions of Cationic Host Defense Peptides in Immunity [PDF]
Pharmaceuticals, 2016 Cationic host defense peptides are a widely distributed family of immunomodulatory molecules with antimicrobial properties. The biological functions of these peptides include the ability to influence innate and adaptive immunity for efficient resolution ...
Mahadevappa Hemshekhar +2 more
doaj +3 more sources
Epithelial antimicrobial peptides in host defense against infection [PDF]
Respiratory Research, 2000 One component of host defense at mucosal surfaces seems to be epithelium-derived antimicrobial peptides. Antimicrobial peptides are classified on the basis of their structure and amino acid motifs.
Bals Robert
doaj +3 more sources
Novel African trypanocidal agents: membrane rigidifying peptides [PDF]
, 2012 The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is conferred by peptide hydrophobicity and charge distribution and results from increased ...
Andreas Hartel +8 more
core +17 more sources
Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action. [PDF]
Int J Mol Sci, 2021 The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial infections to become a global health concern. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), offer a viable solution to these pathogens due to their diverse mechanisms of actions, which include direct killing as well as immunomodulatory ...
Drayton M +6 more
europepmc +4 more sources
Host defense peptides clavanins A and MO reduce in vitro osteoclastogenesis
Brazilian Journal of Oral Sciences, 2021 Aim: Several systemic diseases, such as periodontitis and apical periodontitis, can cause extensive bone resorption. Host defense peptides may have the potential for the development of novel therapies for the bone resorption process. This study evaluated
Ingrid Aquino Amorim +6 more
doaj +1 more source