Regulation of Host Defense Peptide Synthesis by Polyphenols [PDF]
Antibiotics, 2023 The rise of antimicrobial resistance has created an urgent need for antibiotic-alternative strategies for disease control and prevention. Host defense peptides (HDPs), which have both antimicrobial and immunomodulatory properties, are an important ...
Isabel Tobin, Guolong Zhang
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Resistin, a Novel Host Defense Peptide of Innate Immunity [PDF]
Frontiers in Immunology, 2021 Resistin, a cysteine-rich protein, expressed in adipocytes, was initially proposed as a link between obesity and diabetes in mice. In humans, resistin is considered to be a pro-inflammatory molecule expressed in immune cells, which plays a regulatory ...
Yanran Li +9 more
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Impacts of PEGylation and Glycosylation on the Biological Properties of Host Defense Peptide IDR1018 [PDF]
Pharmaceutics, 2023 The multifunctional properties of host defense peptides (HDPs) make them promising drug candidates to tackle bacterial infections and tissue inflammation.
Hashem Etayash +2 more
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Host-Defense-Peptide-Mimicking β-Peptide Polymer Acting as a Dual-Modal Antibacterial Agent by Interfering Quorum Sensing and Killing Individual Bacteria Simultaneously [PDF]
Research, 2023 Host defense peptides (HDPs) are one of the potentially promising agents for infection diseases due to their broad spectrum and low resistance rate, but their clinical applications are limited by proteolytic instability, high-cost, and complicated ...
Wanlin Li +12 more
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Host Defense Peptide-Mimicking Polymers and Polymeric-Brush-Tethered Host Defense Peptides: Recent Developments, Limitations, and Potential Success [PDF]
Pharmaceutics, 2021 Amphiphilic antimicrobial polymers have attracted considerable interest as structural mimics of host defense peptides (HDPs) that provide a broad spectrum of activity and do not induce bacterial-drug resistance.
Hashem Etayash, Robert E. W. Hancock
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Reassessing the Host Defense Peptide Landscape [PDF]
Frontiers in Chemistry, 2019 Current research has demonstrated that small cationic amphipathic peptides have strong potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and anti-inflammatories. Although traditionally termed antimicrobial peptides (
Evan F. Haney +2 more
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Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus Aspergillus fumigatus [PDF]
Microbiology SpectrumAspergillus fumigatus is the primary etiological agent of aspergillosis. Here, we show that the host defense peptide mimetic brilacidin (BRI) can potentiate ibrexafungerp (IBX) against clinical isolates of A. fumigatus.
Thaila Fernanda dos Reis +4 more
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Exploring the impact of the host defense peptide Pap12-6 on immune response and epithelial integrity in chicken-derived ileal explant cultures [PDF]
Poultry ScienceDue to the spread of antimicrobial resistance, there is an urgent need to search for novel antimicrobial agents. In poultry farming, animals are constantly exposed to enteral pathogens and are simultaneously required to maintain high production ...
Rege Anna Márton +10 more
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Hylin-a1: A Host Defense Peptide with Antibacterial Potential against Staphylococcus aureus Multi-Resistant Strains [PDF]
Pharmaceuticals, 2023 In recent years, the resistance of pathogenic microorganisms to common antimicrobial agents has raised to a severe public health problem. The moderate and wise use of antimicrobials and the prevention of infections are the most effective strategies for ...
Annalisa Chianese +8 more
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High-Throughput Identification of Epigenetic Compounds to Enhance Chicken Host Defense Peptide Gene Expression [PDF]
Antibiotics, 2022 Enhancing the synthesis of endogenous host defense peptides (HDPs) has emerged as a novel antibiotic-free approach to infectious disease control and prevention. A number of epigenetic compounds have been identified as HDP inducers and several have proved
Zhuo Deng, Wentao Lyu, Guolong Zhang
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