Results 141 to 150 of about 2,814,854 (281)

A Designed Host Defense Peptide for the Topical Treatment of MRSA-Infected Diabetic Wounds. [PDF]

Int J Mol Sci, 2023
Vargas A, Garcia G, Rivara K, Woodburn K, Clemens LE, Simon SI.   +5 more
europepmc   +1 more source

The Role of Host Defense Peptide Human β-defensins in the Maintenance of Skin Barriers

, 2018
The epidermis functions as a first-line defense barrier that protects the body from the external environment. As a chemical hindrance, the epidermis possesses acidic pH, highly organized lipids and various host defense peptides, also known as ...
Chanisa Kiatsurayanon, Hideoki Ogawa, Francois Niyonsaba   +2 more
core   +1 more source

A Novel Immunosuppressive Effector Functions as a Bio‐Adjuvant to Enhance the Activity of Bacillus Thuringiensis and Chemical Insecticides

Advanced Science, EarlyView.
A previously unrecognized link between quorum sensing and host immune suppression is revealed in Bacillus thuringiensis(Bt). The PlcR‐PapR system induces the novel immunosuppressive effector PisP, which inhibits DAF‐16 nuclear translocation and downstream immune defenses, thereby promoting Bt pathogenicity.
Zhiyu Liu, Feng Chen, Liting Wan, Li Chen, Bowen Zhang, Fanling Li, Haixin Luo, Lixu Li, Alejandra Bravo, Mario Soberón, Dadong Dai, Jinshui Zheng, Ming Sun, Kai Wang, Donghai Peng   +14 more
wiley   +1 more source

Magnetic Resonance Reveals Radical Stability in Native Biofilms and Its Role in Bacterial Resistance

Angewandte Chemie, EarlyView.
The complex biofilm environment consists of planktonic bacterial cells and cells embedded in an extracellular matrix (ECM). Through an integrated magnetic resonance approach, we show that nitroxide radicals primarily interact with the polysaccharides and lipids in the ECM.
Alysia Mandato, Hannah Hunter, Sadhana Srinivasa, Chang‐Hyeock Byeon, Abdulkadir Tunc, Meghan K. Wells, Faith J. Scott, Frederic Mentink‐Vigier, Wook Kim, Sunil Saxena, Ümit Akbey   +10 more
wiley   +2 more sources

Next Generation Antimicrobial Coatings for High Touch Surfaces: Application, Benefits, Risks, Environmental Impacts and Sustainability Aspects

Advanced Science, EarlyView.
Antimicrobial coatings for high touch surfaces promise infection control but are too often validated only in the lab. This review shows that active‐agent release governs both human toxicity and environmental impact and argues that durability and real‐world performance must be primary design criteria, placing a safe‐and‐sustainable‐by‐design framework ...
Nurshen Mutlu, Peter Askew, Alexander J. Cunliffe, Damjana Drobne, Stefan Fischer, Gillian Iredale, Pascal Kock, Veno Kononenko, Susanne Kurz, Patrick Lichtner, Abby Marchant, Philipp Meier, James Redfern, Giacomo Reina, Simone Schulte, Juliane Spohn, Merve Tunali, Peter Wick, Nihal Engin Vrana, Bernd Nowack   +19 more
wiley   +1 more source

Hylin-a1: A Host Defense Peptide with Antibacterial Potential against Staphylococcus aureus Multi-Resistant Strains. [PDF]

Pharmaceuticals (Basel), 2023
Chianese A, Zannella C, Foglia F, Nastri BM, Monti A, Doti N, Franci G, De Filippis A, Galdiero M.   +8 more
europepmc   +1 more source

SUMOylated DDX3 Promotes HBV Replication and Tumor Growth of Hepatocellular Carcinoma via TRIM28‐DDX3‐KLF4α Signaling Axis

Advanced Science, EarlyView.
TRIM28 binds to DDX3 protein to catalyze the SUMOylation of DDX3 (S‐DDX3), thus the S‐DDX3 involves in aberrant alternative splicing of KLF4 mRNA, and the splicing variant KLF4α‐mediated cell cycle and signal transduction, weakens tumor suppressor function of DDX3 protein, which promotes progression of HBV‐HCC.
Yanfang Yang, Ting Kong, Binghan Wang, Xiaoli Jin, Lan Huang, Nan Zhang, Siyu Tang, Samina Ejaz Syed, Shufang Liang   +8 more
wiley   +1 more source

Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape. [PDF]

, 1994
An immediate-early protein of murine cytomegalovirus (MCMV), pp89, elicits an immunodominant and protective major histocompatibility complex (MHC) class I Ld-restricted CD8+ T-lymphocyte response.
Ruppert, Siegfried, Koszinowski, Ulrich H., Lucin, Pero, Jonjic, Stipan, Hengel, Hartmut   +4 more
core  

A Citrulline‐Functionalized Patch Coordinates Macrophage NRF2 Signaling and Arginine Metabolism for Tendon‐to‐Bone Repair

Advanced Science, EarlyView.
A locally implanted patch combines citrulline‐functionalized carbon dots, a thioketal‐containing membrane coating from tendon‐derived stem cells, and aligned core–shell fibers. In macrophages, the patch reduces inflammatory markers and enhances antioxidant signaling through nuclear factor erythroid 2‐related factor 2 (NRF2); in rats and rabbits, it ...
Yuhao Yu, Wencai Liu, Xinyue Yang, Hanzhe Zhang, Hui Xu, Xin Wang, Weimin Lin, Xiping Jiang, Chenrui Yuan, Yifei Wang, Weilin Yu, Yamin Li, Wei Song, Yaohua He   +13 more
wiley   +1 more source

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi. [PDF]

Nat Commun, 2023
Dos Reis TF, de Castro PA, Bastos RW, Pinzan CF, Souza PFN, Ackloo S, Hossain MA, Drewry DH, Alkhazraji S, Ibrahim AS, Jo H, Lightfoot JD, Adams EM, Fuller KK, deGrado WF, Goldman GH.   +15 more
europepmc   +1 more source