Results 11 to 20 of about 181,738 (289)

Effects of gut microbiota and metabolites on the host defense peptide expression [PDF]

Applied Microbiology and Biotechnology
The widespread use of antibiotics has led to the emergence of multidrug-resistant bacteria, which pose significant threats to animal health and food safety.
Yuanli Jin, Tao Gong, Xiaoxi Lu, Yizhen Wang, Yuanzhi Cheng   +4 more
doaj   +2 more sources

Functions of Cationic Host Defense Peptides in Immunity [PDF]

Pharmaceuticals, 2016
Cationic host defense peptides are a widely distributed family of immunomodulatory molecules with antimicrobial properties. The biological functions of these peptides include the ability to influence innate and adaptive immunity for efficient resolution ...
Mahadevappa Hemshekhar, Vidyanand Anaparti, Neeloffer Mookherjee   +2 more
doaj   +3 more sources

Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria [PDF]

, 2013
Background:Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD patients, and pose a huge burden on healthcare. One of the major causes of AECOPD is airway bacterial (e.g.
Bowler, RP, Chu, HW, Jiang, D, Schnell, C, Wenzel, SE, Wu, Q   +5 more
core   +16 more sources

Polyproline Peptide Aggregation with Klebsiella pneumoniae Extracellular Polysaccharides Exposes Biofilm Associated Bacteria

Microbiology Spectrum, 2022
Klebsiella pneumoniae produces a thick capsule layer composed of extracellular polysaccharides protecting the bacterial cells from clearance by innate host immunity during infection.
Renee M. Fleeman, Bryan W. Davies
doaj   +1 more source

Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers

Bioactive Materials, 2021
It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical devices. Host defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant microbes. Our
Ziyi Lu, Yueming Wu, Zihao Cong, Yuxin Qian, Xue Wu, Ning Shao, Zhongqian Qiao, Haodong Zhang, Yunrui She, Kang Chen, Hengxue Xiang, Bin Sun, Qian Yu, Yuan Yuan, Haodong Lin, Meifang Zhu, Runhui Liu   +16 more
doaj   +1 more source

Oncolytic Activities of Host Defense Peptides [PDF]

International Journal of Molecular Sciences, 2011
Cancer continues to be a leading source of morbidity and mortality worldwide in spite of progress in oncolytic therapies. In addition, the incidence of cancers affecting the breast, kidney, prostate and skin among others continue to rise. Chemotherapeutic drugs are widely used in cancer treatment but have the serious drawback of nonspecific toxicity ...
Benna, Sammy al-, Shai, Yechiel (Prof.), Jacobsen, Frank (Dr.), Steinsträßer, Lars (Prof. Dr. med.)   +3 more
openaire   +3 more sources

The Intracellularly Acting Effector Foa3 Suppresses Defense Responses When Infiltrated Into the Apoplast

Frontiers in Plant Science, 2022
Plant pathogens employ secreted proteins, among which are effectors, to manipulate and colonize their hosts. A large fraction of effectors is translocated into host cells, where they can suppress defense signaling.
Nico Tintor, Gea A. M. Nieuweboer, Ilse A. W. Bakker, Frank L. W. Takken   +3 more
doaj   +1 more source

Evolving and assembling to pierce through: Evolutionary and structural aspects of antimicrobial peptides

Computational and Structural Biotechnology Journal, 2022
The burgeoning menace of antimicrobial resistance across the globe has necessitated investigations into other chemotherapeutic strategies to combat infections.
Sukriyo Chakraborty, Ritika Chatterjee, Dipshikha Chakravortty   +2 more
doaj   +1 more source

Defensins: A Double-Edged Sword in Host Immunity

Frontiers in Immunology, 2020
Defensins are a major family of host defense peptides expressed predominantly in neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted immunomodulatory functions have been extensively studied, cementing their role in ...
Dan Xu, Wuyuan Lu
doaj   +1 more source

Flagellin, a plant-defense-activating protein identified from Xanthomonas axonopodis pv. Dieffenbachiae invokes defense response in tobacco

BMC Microbiology, 2023
Background Secretome analysis is a valuable tool to study host-pathogen protein interactions and to identify new proteins that are important for plant health.
Tamilarasi Mani, J. Beslin Joshi, R. Priyadharshini, Jeya Sundara Sharmila, Sivakumar Uthandi   +4 more
doaj   +1 more source