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Frontiers in Medicine, 2022 Sight is arguably the most important sense in human. Being constantly exposed to the environmental stress, irritants and pathogens, the ocular surface – a specialized functional and anatomical unit composed of tear film, conjunctival and corneal ...
Darren Shu Jeng Ting +7 more
doaj +1 more source
Frontiers in Immunology, 2017 Host-defense peptides play a fundamental role in the innate immune system by modulating inflammatory responses. Previously, it was shown that the thrombin derived host-defense peptide GKY25 inhibits LPS-induced responses of monocytes and macrophages in ...
Finja C. Hansen +6 more
doaj +1 more source
Virulence, 2020 Entomopathogenic fungi naturally infect insect hosts in environment. Fungal invasion and host immune defense are still in the progress of co-evolution. In this study, entomopathogenic fungus Beauveria bassiana and lepidopteran insect Galleria mellonella ...
Jin-Li Ding +3 more
doaj +1 more source
Cn-AMP2 from green coconut water is an anionic anticancer peptide [PDF]
, 2014 Globally, death due to cancers is likely to rise to over 20 million by 2030,which has created an urgent need for novel approaches to anticancer therapies such as the development of host defence peptides.
Al-Benna +56 more
core +1 more source
Antimicrobial peptides in echinoderm host defense [PDF]
Developmental & Comparative Immunology, 2015 Antimicrobial peptides (AMPs) are important effector molecules in innate immunity. Here we briefly summarize characteristic traits of AMPs and their mechanisms of antimicrobial activity. Echinoderms live in a microbe-rich marine environment and are known to express a wide range of AMPs. We address two novel AMP families from coelomocytes of sea urchins:
Li, Chun +3 more
openaire +3 more sources
In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection [PDF]
, 2017 Pseudomonas aeruginosa is an opportunistic and frequently drug-resistant pulmonary pathogen especially in cystic fibrosis sufferers. Recently, the frog skin-derived antimicrobial peptide (AMP) Esc(1-21) and its diastereomer Esc(1-21)-1c were found to ...
Chen, Chen +2 more
core +1 more source
Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action [PDF]
International Journal of Molecular Sciences, 2021 The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial infections to become a global health concern. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), offer a viable solution to these pathogens due to their diverse mechanisms of actions, which include direct killing as well as immunomodulatory ...
Matthew Drayton +6 more
openaire +2 more sources
Antimicrobial peptides: agents of border protection for companion animals. [PDF]
, 2012 Over the past 20 years, there have been significant inroads into understanding the roles of antimicrobial peptides in homeostatic functions and their involvement in disease pathogenesis.
Affolter, Verena K +2 more
core +1 more source
Dietary Nutrients Mediate Intestinal Host Defense Peptide Expression. [PDF]
Adv Nutr, 2020 The intestinal tract is the shared locus of intestinal epithelial cells, immune cells, nutrient digestion and absorption, and microbial survival. The gut in animals faces continuous challenges in communicating with the external environment. Threats from endogenous imbalance and exogenous feeds, especially pathogens, could trigger a disorder of ...
Wu J, Ma N, Johnston LJ, Ma X.
europepmc +4 more sources
Immunomodulatory Activities of Small Host Defense Peptides [PDF]
Antimicrobial Agents and Chemotherapy, 2005 ABSTRACT Recent studies have demonstrated that in addition to their antimicrobial activity, cationic host defense peptides, like the human cathelicidin LL-37, perform many activities relating to innate immunity, including the induction or modulation of chemokine and cytokine production, alteration of gene expression in host cells,
Bowdish, Dawn M E +3 more
openaire +3 more sources