Results 41 to 50 of about 181,738 (289)
Interactions Between the Gut Microbiota and the Host Innate Immune Response Against Pathogens
Frontiers in Immunology, 2019 The mammalian intestine is colonized by over a trillion microbes that comprise the “gut microbiota,” a microbial community which has co-evolved with the host to form a mutually beneficial relationship.
Hong-Yu Cheng +3 more
doaj +1 more source
Modulation of antimicrobial host defense peptide gene expression by free fatty acids. [PDF]
PLoS ONE, 2012 Routine use of antibiotics at subtherapeutic levels in animal feed drives the emergence of antimicrobial resistance. Development of antibiotic-alternative approaches to disease control and prevention for food animals is imperatively needed.
Lakshmi T Sunkara +2 more
doaj +1 more source
Clinical Significance of Serum Elafin in Children with Inflammatory Bowel Disease
Biomedicines, 2022 Background: The role of elafin in the pathophysiology of inflammatory bowel disease (IBD) has not been not elucidated. We aimed to evaluate serum elafin in children with IBD and assess its relationship with disease activity. Methods: We enrolled children
Paulina Krawiec +1 more
doaj +1 more source
Frontiers in Microbiology, 2020 Can antimicrobial activity and peptide stability of alpha-helical peptides be increased by making them into dimers and macrocycles? Here, we explore that concept by using KR-12 as the starting point for peptide engineering.
Sunithi Gunasekera +4 more
doaj +1 more source
Lactoferrin. A natural glycoprotein involved in iron and inflammatory homeostasis [PDF]
, 2017 Human lactoferrin (hLf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, is a key element of host defenses.
Cutone, Antimo +4 more
core +2 more sources
Optimizing Antimicrobial Host Defense Peptides
Chemistry & Biology, 2006 Antimicrobial host defense peptides constitute a major component of innate immune systems. Expectations are high to develop them into a novel class of anti-infective agents. In this issue of Chemistry & Biology, Hilpert et al. describe new design and peptide synthesis strategies for systematically investigating such concepts.
openaire +2 more sources
Frontiers in Immunology, 2020 Host defense peptides, abundantly secreted by colonic epithelial cells and leukocytes, are proposed to be critical components of an innate immune response in the colon against enteropathogenic bacteria, including Shigella spp., Salmonella spp ...
Graham A. D. Blyth +3 more
doaj +1 more source
Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection. [PDF]
PLoS ONE, 2017 Pseudomonas aeruginosa is a frequent cause of lung infections, particularly in chronic infections in cystic fibrosis patients. However, treatment is challenging due to P.
Kelli C Wuerth +2 more
doaj +1 more source
Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]
, 2002 Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core +1 more source
Multifunctional host defense peptides: intracellular‐targeting antimicrobial peptides [PDF]
The FEBS Journal, 2009 There is widespread acceptance that cationic antimicrobial peptides, apart from their membrane‐permeabilizing/disrupting properties, also operate through interactions with intracellular targets, or disruption of key cellular processes. Examples of intracellular activity include inhibition of DNA and protein synthesis, inhibition of chaperone‐assisted ...
openaire +2 more sources