Results 11 to 20 of about 2,543,243 (266)
Proteolysis of human thrombin generates novel host defense peptides. [PDF]
PLoS Pathogens, 2010 The coagulation system is characterized by the sequential and highly localized activation of a series of serine proteases, culminating in the conversion of fibrinogen into fibrin, and formation of a fibrin clot.
Praveen Papareddy +7 more
doaj +3 more sources
Host defense peptides clavanins A and MO reduce in vitro osteoclastogenesis [PDF]
Brazilian Journal of Oral Sciences, 2021 Aim: Several systemic diseases, such as periodontitis and apical periodontitis, can cause extensive bone resorption. Host defense peptides may have the potential for the development of novel therapies for the bone resorption process. This study evaluated
Ingrid Aquino Amorim +6 more
doaj +2 more sources
Antiviral Activities of Human Host Defense Peptides [PDF]
Current Medicinal Chemistry, 2020 Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout nature. As they participate in a number of different aspects of innate immunity in mammals, they have been termed Host Defense Peptides (HDPs).
Gill Diamond, David C Brice
exaly +4 more sources
Host defense peptides in wound healing.
Molecular Medicine, 2008 Host defense peptides are effector molecules of the innate immune system. They show broad antimicrobial action against gram-positive and -negative bacteria, and they likely play a key role in activating and mediating the innate as well as adaptive immune
Steinstraesser, L;Koehler, T;Jacobsen, F;Daigeler, A;Goertz, O;Langer, S;Kesting, M;Steinau, H;Eriksson, E;Hirsch, T
core +3 more sources
Developmental & Comparative Immunology, 2013 Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi.
Albert van Dijk +10 more
core +5 more sources
Cathelicidin Host Defense Peptides and Inflammatory Signaling: Striking a Balance [PDF]
Frontiers in Microbiology, 2020 Host-defense peptides (HDPs) are vital components of innate immunity in all vertebrates. While their antibacterial activity toward bacterial cells was the original focus for research, their ability to modulate immune and inflammatory processes has ...
Morgan A. Alford +5 more
doaj +2 more sources
Human and Marine Host Defense Peptides for Healthy Skin [PDF]
Marine DrugsThe skin serves as the first line barrier of innate immunity, protecting the body from external influences and maintaining its homeostasis. Exogenous and endogenous stress factors alter the structure and functional properties of the skin.
Svetlana V. Guryanova +2 more
doaj +2 more sources
Host defense peptides of thrombin modulate inflammation and coagulation in endotoxin-mediated shock and Pseudomonas aeruginosa sepsis. [PDF]
PLoS ONE, 2012 Gram-negative sepsis is accompanied by a disproportionate innate immune response and excessive coagulation mainly induced by endotoxins released from bacteria. Due to rising antibiotic resistance and current lack of other effective treatments there is an
Martina Kalle +8 more
doaj +3 more sources
Host Defense Peptides as Templates for Antifungal Drug Development [PDF]
Journal of Fungi, 2020 Current treatment for invasive fungal diseases is limited to three classes of antifungal drugs: azoles, polyenes, and echinocandins. The most recently introduced antifungal class, the echinocandins, was first approved nearly 30 years ago.
Virginia Basso +3 more
doaj +2 more sources
Immunomodulatory activities of small host defense peptides [PDF]
Antimicrobial Agents and Chemotherapy, 2005 Recent studies have demonstrated that in addition to their antimicrobial activity, cationic host defense peptides, like the human cathelicidin LL-37, perform many activities relating to innate immunity, including the induction or modulation of chemokine ...
Scott, Monisha G +3 more
core +4 more sources