Results 21 to 30 of about 146,459 (283)
Molecules, 2023 Antimicrobial peptides (AMPs) are essential components of innate immunity across all species. AMPs have become the focus of attention in recent years, as scientists are addressing antibiotic resistance, a public health crisis that has reached epidemic ...
Caroline Donaghy +4 more
doaj +1 more source
Oncolytic Activities of Host Defense Peptides [PDF]
International Journal of Molecular Sciences, 2011 Cancer continues to be a leading source of morbidity and mortality worldwide in spite of progress in oncolytic therapies. In addition, the incidence of cancers affecting the breast, kidney, prostate and skin among others continue to rise. Chemotherapeutic drugs are widely used in cancer treatment but have the serious drawback of nonspecific toxicity ...
Benna, Sammy al- +3 more
openaire +3 more sources
Microbiology Spectrum, 2022 Klebsiella pneumoniae produces a thick capsule layer composed of extracellular polysaccharides protecting the bacterial cells from clearance by innate host immunity during infection.
Renee M. Fleeman, Bryan W. Davies
doaj +1 more source
Proteolysis of human thrombin generates novel host defense peptides. [PDF]
PLoS Pathogens, 2010 The coagulation system is characterized by the sequential and highly localized activation of a series of serine proteases, culminating in the conversion of fibrinogen into fibrin, and formation of a fibrin clot.
Praveen Papareddy +7 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 The burgeoning menace of antimicrobial resistance across the globe has necessitated investigations into other chemotherapeutic strategies to combat infections.
Sukriyo Chakraborty +2 more
doaj +1 more source
Antimicrobial peptides: agents of border protection for companion animals. [PDF]
, 2012 Over the past 20 years, there have been significant inroads into understanding the roles of antimicrobial peptides in homeostatic functions and their involvement in disease pathogenesis.
Affolter, Verena K +2 more
core +1 more source
Antiviral Activities of Human Host Defense Peptides. [PDF]
Curr Med Chem, 2020 Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout nature. As they participate in a number of different aspects of innate immunity in mammals, they have been termed Host Defense Peptides (HDPs). Due to their common structural features, including an amphipathic structure and cationic charge, they have been widely ...
Brice DC, Diamond G.
europepmc +3 more sources
Frontiers in Microbiology, 2013 Lipopolysaccharides (LPS) are the major molecular component of the outer membrane of Gram-negative bacteria. This molecule is recognized as a sign of bacterial infection, responsible for the development of local inflammatory response and, in extreme ...
Carlos eLopez-Abarrategui +4 more
doaj +1 more source
Reassessing the Host Defense Peptide Landscape [PDF]
Frontiers in Chemistry, 2019 Current research has demonstrated that small cationic amphipathic peptides have strong potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and anti-inflammatories. Although traditionally termed antimicrobial peptides (AMPs) these additional roles have prompted a shift in terminology to use the broader term host ...
Evan F. Haney +2 more
openaire +3 more sources
Natural Antimicrobial Peptides: Pleiotropic Molecules in Host Defense [PDF]
, 2013 Natural antimicrobial peptides (AMPs) are small cationic molecules that display antimicrobial activity against a wide range of bacteria, fungi and viruses.
Maffia, Paulo Cesar +2 more
core +1 more source