Results 41 to 50 of about 871,394 (166)

Micro-Scale Vacuum Compression Molding as a Predictive Screening Tool of Protein Integrity for Potential Hot-Melt Extrusion Processes

Pharmaceutics, 2023
Hot-melt extrusion (HME) is used for the production of solid protein formulations mainly for two reasons: increased protein stability in solid state and/or long-term release systems (e.g., protein-loaded implants).
Katharina Dauer, Karl G. Wagner
doaj   +1 more source

Dissolution-permeation of hot-melt extruded amorphous solid dispersion comprising an experimental grade of HPMCAS

ADMET and DMPK, 2023
Background and purpose: Physicochemical properties of an amorphous solid dispersion (ASD) comprising an experimental grade of hydroxypropyl methylcellulose acetate succinate (HPMCAS-MX) with lower glass transition temperature have been previously ...
Hironori Tanaka, Tetsuya Miyano, Hiroshi Ueda   +2 more
doaj   +1 more source

Advanced Pharmaceutical Applications of Hot-Melt Extrusion Coupled with Fused Deposition Modelling (FDM) 3D Printing for Personalised Drug Delivery

Pharmaceutics, 2018
Three-dimensional printing, also known as additive manufacturing, is a fabrication process whereby a 3D object is created layer-by-layer by depositing a feedstock material such as thermoplastic polymer. The 3D printing technology has been widely used for
Deck Khong Tan, Mohammed Maniruzzaman, Ali Nokhodchi   +2 more
doaj   +1 more source

Hot melt extrusion (HME) for amorphous solid dispersions: Predictive tools for processing and impact of drug–polymer interactions on supersaturation

European Journal of Pharmaceutical Sciences, 2013
The processing parameters for HME have been evaluated and the impact of solid state intermolecular drug-polymer interactions on supersaturation has been investigated. Poorly water soluble drugs Indomethacin (IND), Itraconazole (ITZ), and Griseofulvin (GSF) and hydrophilic polymers - Eudragit EPO, Eudragit L-100-55, Eudragit L-100, HPMCAS-LF, HPMCAS-MF,
Ashish L, Sarode, Harpreet, Sandhu, Navnit, Shah, Waseem, Malick, Hossein, Zia   +4 more
openaire   +2 more sources

Low temperature hot melt extrusion of polycaprolactone/polyethylene oxide/chitosan ternary blends for biocompatible implantable device development

Materials & Design
Rising demand for biomedical devices requires manufacturing approaches suitable for processing thermally-sensitive materials. Hot-melt extrusion may cause thermal degradation of polymers and bioactives.
Philbert Nshimiyimana, Declan Mary Colbert, Zeeshan Ali, Ciara Buckley   +3 more
doaj   +1 more source

Next‐Generation Pluronic Micelles for Advanced Drug Delivery Application

Macromolecular Materials and Engineering, Volume 311, Issue 9, September 2026.
The present review provides a comprehensive overview of Pluronic‐based micelles for advanced drug and gene delivery. It highlights their structure, classification, synthesis, self‐assembly, and functionalization, as well as their biocompatibility and stimuli‐responsive properties.
Manoj Gundeti, Nithin Vidiyala, Shreya Dalvi, Rushikesh Girase, Sunil kumar Thota, Keshav Raj Paudel, Sathish Dyawanapelly   +6 more
wiley   +1 more source

Process monitoring and visualization solutions for hot-melt extrusion : a review [PDF]

, 2014
Objectives: Hot-melt extrusion (HME) is applied as a continuous pharmaceutical manufacturing process for the production of a variety of dosage forms and formulations.
Remon, Jean Paul, De Beer, Thomas, Vervaet, Chris, Saerens, Lien   +3 more
core   +1 more source

Effect of Chitosan‐Alginate Polyelectrolyte Complex Formation and Multilayer Polymer Configuration on the Characteristics of 3D‐Printed Metronidazole‐Loaded Periodontal Films

Biopolymers, Volume 117, Issue 4, July 2026.
The preparation and characterization of metronidazole loaded chitosan and alginate gels, followed by polyelectrolyte complex formation and 3D printing of multilayer periodontal films. ABSTRACT This study aimed to prepare six different metronidazole‐loaded film formulations by 3D printing for periodontal treatment.
Dicle Denizhan, Ayse Nur Buke, Muge Kilicarslan, Kaan Orhan, Hilal Basak Erol, Banu Kaskatepe   +5 more
wiley   +1 more source

Population Pharmacokinetics and Exposure‐Response Analyses for Ubrogepant Efficacy and Safety in the Acute Treatment of Migraine: Analysis of Phase 1–3 Studies

The Journal of Clinical Pharmacology, Volume 66, Issue 6, June 2026.
Abstract A population pharmacokinetic (popPK) model was developed for ubrogepant using data from 10 Phase 1, 1 Phase 2, and 2 Phase 3 studies. The data were described by a 2‐compartment model with linear elimination and transit compartment absorption. Formulation, food intake, race, gender, and hepatic impairment had a statistically significant impact ...
Sven Stodtmann, Lucia Siovitz, Heiko Babel, Ramesh R. Boinpally   +3 more
wiley   +1 more source

Hot-Melt Extrusion-Based Dexamethasone–PLGA Implants: Physicochemical, Physicomechanical, and Surface Morphological Properties and In Vitro Release Corrected for Drug Degradation

Pharmaceutics
Developing bioequivalent (BE) generic products of complex dosage forms like intravitreal implants (IVIs) of corticosteroids such as dexamethasone prepared using hot-melt extrusion (HME), based on biodegradable poly (lactide-co-glycolide) (PLGA) polymers,
Alireza (Allen) Ghaffari, Brock A. Matter, Rachel R. Hartman, David W. A. Bourne, Yan Wang, Stephanie Choi, Uday B. Kompella   +6 more
doaj   +1 more source