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FROM CONCEPT TO DELIVERY: THE EVOLUTION AND APPLICATIONS OF HOT-MELT EXTRUSION IN PHARMACEUTICALS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut UniversityHot Melt Extrusion (HME) is an innovative approach that is currently receiving significant interest in the pharmaceutical sector for the manufacturing of various dosage forms.
Jigar Vyas, Nensi Raytthatha
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Towards predicting the product quality in hot-melt extrusion: Pilot plant scale extrusion
International Journal of Pharmaceutics: X, 2021 Following our study on the impact of hot melt extrusion (HME) process conditions on the product quality, we expanded our investigation to assessing the effect of scale-up on the product quality.
Josip Matić +5 more
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Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation
Pharmaceutics, 2018 A validation for the use of model-based melt viscosity in hot-melt extrusion numerical simulations was presented. Here, the melt viscosity of an amorphous solid dispersion (ASD) was calculated by using its glass transition temperature (Tg) and the ...
Esther S. Bochmann +2 more
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Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate
Pharmaceutics, 2022 The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME).
Lena Hoffmann +2 more
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Impact of the manufacturing technique on the dissolution-enhancement functionality of PEG4000 in Cilostazol tablets [PDF]
Pharmacia, 2021 Cilostazol was selected as poorly-soluble model drug to investigate the impact of the manufacturing method on the excipient functionality of PEG4000 at various levels.
Obada Sawafta +4 more
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Pharmaceutics, 2018 Hot-melt extrusion (HME) is a well-accepted and extensively studied method for preparing numerous types of drug delivery systems and dosage forms. It offers several advantages: no solvents are required, it is easy to scale up and employ on the industrial
Roberta Censi +3 more
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Pharmaceutics, 2020 Amorphous solid dispersions (ASDs) are commonly used in the pharmaceutical industry to improve the dissolution and bioavailability of poorly water-soluble drugs. Hot melt extrusion (HME) has been employed to prepare ASD based products.
Xiangyu Ma +6 more
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Pharmaceutics, 2021 A biodegradable copolyester, poly(butylene succinate-co-ε-caprolactone) (PBS_CL), was used for first time as an excipient for pharmaceutical dosage forms using direct compression and hot processing techniques (ultrasound-assisted compression (USAC) and ...
Eduardo Galdón +4 more
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Pharmaceutics, 2020 Hot-melt extrusion (HME) is the most preferred and effective method for manufacturing amorphous solid dispersions at production scale, but it consumes large amounts of samples when used for formulation development.
Gauri Shadambikar +6 more
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Pharmaceutics, 2021 Conventional oral dosage forms may not always be optimal especially for those patients suffering from dysphasia or difficulty swallowing. Development of suitable oral thin films (OTFs), therefore, can be an excellent alternative to conventional dosage ...
Jiaxiang Zhang +4 more
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