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International Journal of Membrane Science and Technology, 2023 The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology's promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized. The numerous published publications over the past five years show that hot melt extrusion (HME) technology is increasingly being ...
Shahid Jamil +2 more
openaire +2 more sources
Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique
Iraqi Journal of Pharmaceutical Sciences, 2018 The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone s630 was utilized.
Ahmed S. Abdul Jabbar
doaj +3 more sources
Pharmaceutics, 2019 Recently, hot-melt extrusion (HME) techniques have been presented as innovative platforms to produce various pharmaceuticals [...]
Mohammed Maniruzzaman
doaj +2 more sources
Pharmaceutics, 2022 Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations via the hot ...
Stefanie Dohrn +2 more
exaly +3 more sources
Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties [PDF]
, 2016 Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped ...
Martinez-Marcos, Laura +2 more
core +6 more sources
Drug Delivery and Translational Research, 2019 Solid lipid nanoparticles (SLN) have been formulated using various batch processes, e.g., solvent diffusion evaporation, emulsification solvent evaporation followed by size reduction using high-pressure homogenization (HPH) or ultrasonication. However, for the manufacturing of formulations, continuous processes are always preferred over batch processes
Shallu Kutlehria +2 more
exaly +3 more sources
Evaluation of Process Parameters in the Development of Ternary Ketoprofen Amorphous Solid Dispersions via Hot Melt Extrusion. [PDF]
PharmaceuticsBackground/Objectives: Poor aqueous solubility of active pharmaceutical ingredients (APIs) remains a critical barrier to effective oral formulation. This study investigated the production of ketoprofen amorphous solid dispersions (ASDs) via hot melt ...
Stjepanović A +6 more
europepmc +2 more sources
Process Development for the Continuous Manufacturing of Carbamazepine-Nicotinamide Co-Crystals Utilizing Hot-Melt Extrusion Technology. [PDF]
PharmaceuticsObjectives: Hot-melt extrusion (HME) offers a solvent-free, scalable approach for manufacturing pharmaceutical co-crystals (CCs), aligning with the industry’s shift to continuous manufacturing (CM).
Huang L +6 more
europepmc +2 more sources
Drug Design, Development and Therapy, 2015 Jae-Young Lee,1,* Wie-Soo Kang,2,* Jingpei Piao,2 In-Soo Yoon,3 Dae-Duk Kim,1 Hyun-Jong Cho4 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 2School of Bioscience and Biotechnology, Kangwon ...
Lee JY +5 more
doaj +1 more source
Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion - III: Polymethacrylates and polymethacrylic acid based polymers [PDF]
Journal of Excipients and Food Chemicals, 2016 Polymers are a major part of final medicinal drug products prepared by hot melt extrusion (HME). Therefore it is necessary to understand their behavior when subjected to heat and mechanical stresses during the development of the HME processes. The aim of
Tapan Parikh +3 more
doaj +1 more source