Results 11 to 20 of about 924,399 (169)
Quality by Design Approach for Hot-Melt Extrusion Coupled Fused Deposition Modeling (HME-FDM) 3D Printing: A Systematic Review [PDF]
PharmaceuticsBackground: Fused deposition modeling (FDM) is one of the most well-known and often published methods for 3D-printed drug delivery systems. In early scientific reports, the active pharmaceutical ingredients were added by soaking, but later, a new milestone was established, after researchers started to manufacture their own filaments by hot-melt ...
Ildikó Bácskay +2 more
exaly +5 more sources
Pharmaceutics, 2019 Recently, hot-melt extrusion (HME) techniques have been presented as innovative platforms to produce various pharmaceuticals [...]
Mohammed Maniruzzaman
doaj +2 more sources
Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique
Iraqi Journal of Pharmaceutical Sciences, 2018 The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone s630 was utilized.
Ahmed S. Abdul Jabbar
doaj +3 more sources
Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process [PDF]
Pharmaceutics, 2018 Hot-melt extrusion (HME) is a well-accepted and extensively studied method for preparing numerous types of drug delivery systems and dosage forms. It offers several advantages: no solvents are required, it is easy to scale up and employ on the industrial
Roberta Censi +3 more
doaj +3 more sources
Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion
Pharmaceutics, 2022 Even though hot melt extrusion (HME) is a commonly applied process in the pharmaceutical area, determination of the optimal process parameters is demanding.
Tobias Gottschalk +3 more
doaj +2 more sources
A review on the taste masking of bitter APIs: hot-melt extrusion (HME) evaluation
Drug Development and Industrial Pharmacy, 2013 The majority of active pharmaceutical ingredients (APIs) found in oral dosage forms have a bitter taste. Masking the unpleasant taste of bitter, APIs is a major challenge in the development of such oral dosage forms. Taste assessment is an important quality-control parameter for evaluating taste-masked formulations of any new molecular entity. Hot-melt
Mohammed, Maniruzzaman +4 more
openaire +3 more sources
Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation
Pharmaceutics, 2018 A validation for the use of model-based melt viscosity in hot-melt extrusion numerical simulations was presented. Here, the melt viscosity of an amorphous solid dispersion (ASD) was calculated by using its glass transition temperature (Tg) and the ...
Esther S. Bochmann +2 more
doaj +2 more sources
Sustained release dosage form of noscapine HCl using hot melt extrusion (HME) technique: formulation and pharmacokinetics. [PDF]
Drug Deliv Transl Res, 2021 Sustained release formulation of noscapine (Nos) HCl could be useful in maintaining plasma Nos HCl level for prolonged period of time, which is important for chemo-sensitization. However, weakly basic drugs like Nos HCl have pH-dependent solubility.
Bagde A +4 more
europepmc +4 more sources
Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties [PDF]
, 2016 Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped ...
Martinez-Marcos, Laura +2 more
core +5 more sources
Drug Design, Development and Therapy, 2015 Jae-Young Lee,1,* Wie-Soo Kang,2,* Jingpei Piao,2 In-Soo Yoon,3 Dae-Duk Kim,1 Hyun-Jong Cho4 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 2School of Bioscience and Biotechnology, Kangwon ...
Lee JY +5 more
doaj +1 more source