Results 1 to 10 of about 924,399 (169)

In-Line UV-Vis Spectroscopy as a Fast-Working Process Analytical Technology (PAT) During Early Phase Product Development Using Hot Melt Extrusion (HME) [PDF]

Pharmaceutics, 2018
This paper displays the potential of an in-line PAT system for early phase product development during pharmaceutical continuous manufacturing following a Quality by Design (QbD) framework. Hot melt extrusion (HME) is used as continuous manufacturing process and UV–Vis spectroscopy as an in-line monitoring system. A sequential design of experiments (DoE)
Walkiria Schlindwein
exaly   +6 more sources

Machine Learning for Process Monitoring and Control of Hot-Melt Extrusion: Current State of the Art and Future Directions

Pharmaceutics, 2021
In the last few decades, hot-melt extrusion (HME) has emerged as a rapidly growing technology in the pharmaceutical industry, due to its various advantages over other fabrication routes for drug delivery systems. After the introduction of the ‘quality by
Nimra Munir, Michael Nugent, Darren Whitaker, Marion McAfee   +3 more
doaj   +3 more sources

The Effect of Hot-Melt Extrusion of Mulberry Leaf on the Number of Active Compounds and Antioxidant Activity

Plants, 2022
The aim of this study is to compare the functions of the physiologically active compounds of three types of mulberry leaf by cultivar, and to confirm the changes using hot-melt extrusion (HME−ML).
Hyun-Bok Kim, Suji Ryu, Jong-Suep Baek
doaj   +3 more sources

Sustainable Design and DoE-Based Optimization of Polymeric Systems for FDM 3D-Printed Indomethacin Amorphous Solid Dispersions [PDF]

Pharmaceuticals
Background/Objectives: Amorphous solid dispersions (ASDs) produced via hot-melt extrusion (HME) and fused deposition modeling (FDM) 3D printing represent a promising strategy for improving the performance of poorly water-soluble drugs.
Ioannis Pantazos, Christos Cholevas, Christos Vlachokostas, Afroditi Kapourani, Panagiotis Barmpalexis   +4 more
doaj   +2 more sources

Vertical Hot-Melt Extrusion: The Next Challenge in Innovation [PDF]

Pharmaceutics
Background/Objectives: Hot-melt extrusion (HME) has become a key technology in pharmaceutical formulation, particularly for enhancing the solubility of poorly soluble Active Pharmaceutical Ingredients (APIs).
Maël Gallas, Ghouti Medjahdi, Pascal Boulet, Victoire de Margerie   +3 more
doaj   +2 more sources

Rheology-Informed Working Thresholds for HME/FDM Processability in a PVA–Sorbitol–Paracetamol Model System [PDF]

Pharmaceutics
Background/Objectives: Oscillatory rheology is widely used in hot-melt extrusion (HME) and fused deposition modeling (FDM), but its translation into compact formulation-screening criteria remains limited.
Sofiya Ilieva, Dilyana Georgieva, Valentina Petkova, Milen Dimitrov   +3 more
doaj   +2 more sources

Characterization of Different Copovidone Grades as Carrier Materials in Hot Melt Extrusion of Amorphous Solid Dispersions [PDF]

Pharmaceutics
Background/Objectives: Copovidone (polyvinylpyrrolidone-vinyl acetate copolymer, PVP/VA) is a widely used pharmaceutical excipient with various applications in drug formulation.
Marvin Daalmann, Vincent Kimmel, Christian Muehlenfeld, Markus Thommes, Judith Winck   +4 more
doaj   +2 more sources

A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion Formulation Development

Pharmaceutics, 2022
Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations via the hot ...
Samuel O. Kyeremateng, Kristin Voges, Stefanie Dohrn, Ekaterina Sobich, Ute Lander, Stefan Weber, David Gessner, Rachel C. Evans, Matthias Degenhardt   +8 more
doaj   +3 more sources

Evaluation of Process Parameters in the Development of Ternary Ketoprofen Amorphous Solid Dispersions via Hot Melt Extrusion [PDF]

Pharmaceutics
Background/Objectives: Poor aqueous solubility of active pharmaceutical ingredients (APIs) remains a critical barrier to effective oral formulation. This study investigated the production of ketoprofen amorphous solid dispersions (ASDs) via hot melt ...
Ana Stjepanović, Nemanja Todorović, Mihalj Poša, Ivana Marinković, Ivan Ristić, Zita Farkaš Agatić, Mladena Lalić-Popović   +6 more
doaj   +2 more sources

Process Development for the Continuous Manufacturing of Carbamazepine-Nicotinamide Co-Crystals Utilizing Hot-Melt Extrusion Technology [PDF]

Pharmaceutics
Objectives: Hot-melt extrusion (HME) offers a solvent-free, scalable approach for manufacturing pharmaceutical co-crystals (CCs), aligning with the industry’s shift to continuous manufacturing (CM).
Lianghao Huang, Wen Ni, Yaru Jia, Minqing Zhu, Tiantian Yang, Mingchao Yu, Jiaxiang Zhang   +6 more
doaj   +2 more sources