Results 21 to 30 of about 924,399 (169)
Personalized 3D-Printed Affinisol-Based Pharmaceutical Delivery Systems: The Case Study for Alternative Sulfonamides for Alzheimer's Disease. [PDF]
Macromol BiosciPersonalized dosage forms engineered via hot‐melt extrusion and FDM 3D‐printing enable the evaluation of novel anti‐Alzheimer's compounds. The study integrates dissolution testing, thermo‐analytical profiling, physico‐chemical characterization, cytotoxicity, and stability to advance personalized medicine in drug development.
Nevyhoštěná M +7 more
europepmc +2 more sources
Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion - III: Polymethacrylates and polymethacrylic acid based polymers [PDF]
Journal of Excipients and Food Chemicals, 2016 Polymers are a major part of final medicinal drug products prepared by hot melt extrusion (HME). Therefore it is necessary to understand their behavior when subjected to heat and mechanical stresses during the development of the HME processes. The aim of
Tapan Parikh +3 more
doaj +1 more source
Hot-Melt Extrusion: pharmaceutical applications
, 2012 Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and ...
Douroumis, Dennis
core +5 more sources
Novel Applications of Hot Melt Extrusion Technology [PDF]
, 2023 Hot melt extrusion (HME) technology was introduced to pharmaceuticals in the 1970s for manufacturing and product development. Since then, there were several developments in HME technology to utilize it effectively for the manufacturing of pharmaceuticals.
Thalluri, Chandrashekar +9 more
core +1 more source
International Journal of Translational Medicine, 2022 Hot-melt extrusion (HME) has been an alternative technique to improve the solubility and bioavailability of active molecules with low water solubility.
Suji Ryu +3 more
doaj +1 more source
Extrusion for pharma applications: An update
SPE Polymers, 2023 This paper aims to give an overview of our current research and development on hot‐melt extrusion (HME) for pharmaceutical formulation and drug delivery. Unfortunately, a large percentage of marketed drugs (40%) and those in the development pipeline (90%)
Maël Gallas +2 more
doaj +1 more source
Pharmaceutics, 2020 The aim of this study was to control the dissolution rate and permeability of cilostazol. To enhance the dissolution rate of the active pharmaceutical ingredient (API), hot-melt extrusion (HME) technology was applied to prepare a solid dispersion (SD ...
Sung-Min Choi +3 more
doaj +1 more source
Pharmaceutics, 2023 Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion complexes to ...
Siva Ram Munnangi +7 more
doaj +1 more source
Investigation of Thermal and Viscoelastic Properties of Polymers Relevant to Hot Melt Extrusion, IV: Affinisol™ HPMC HME Polymers [PDF]
AAPS PharmSciTech, 2015 Most cellulosic polymers cannot be used as carriers for preparing solid dispersion of drugs by hot melt extrusion (HME) due to their high melt viscosity and thermal degradation at high processing temperatures. Three HME-grade hydroxypropyl methylcelluloses, namely Affinisol™ HPMC HME 15 cP, Affinisol™ HPMC HME 100 cP, and Affinisol™ HPMC HME 4 M, have ...
Simerdeep Singh, Gupta +2 more
openaire +6 more sources
Hot-Melt Extrusion (HME): From Process to Pharmaceutical Applications [PDF]
, 2012 None
Mohammed Maniruzzaman +3 more
openaire +2 more sources