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Hot-Melt Extrusion: pharmaceutical applications
, 2012 Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and ...
Douroumis, Dennis
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Novel Applications of Hot Melt Extrusion Technology [PDF]
, 2023 Hot melt extrusion (HME) technology was introduced to pharmaceuticals in the 1970s for manufacturing and product development. Since then, there were several developments in HME technology to utilize it effectively for the manufacturing of pharmaceuticals.
Thalluri, Chandrashekar +9 more
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International Journal of Translational Medicine, 2022 Hot-melt extrusion (HME) has been an alternative technique to improve the solubility and bioavailability of active molecules with low water solubility.
Suji Ryu +3 more
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Extrusion for pharma applications: An update
SPE Polymers, 2023 This paper aims to give an overview of our current research and development on hot‐melt extrusion (HME) for pharmaceutical formulation and drug delivery. Unfortunately, a large percentage of marketed drugs (40%) and those in the development pipeline (90%)
Maël Gallas +2 more
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Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion
Pharmaceutics, 2022 Even though hot melt extrusion (HME) is a commonly applied process in the pharmaceutical area, determination of the optimal process parameters is demanding.
Tobias Gottschalk +3 more
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Pharmaceutics, 2020 The aim of this study was to control the dissolution rate and permeability of cilostazol. To enhance the dissolution rate of the active pharmaceutical ingredient (API), hot-melt extrusion (HME) technology was applied to prepare a solid dispersion (SD ...
Sung-Min Choi +3 more
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Pharmaceutics, 2023 Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion complexes to ...
Siva Ram Munnangi +7 more
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Hot-Melt Extrusion (HME): From Process to Pharmaceutical Applications [PDF]
, 2012 Over the last three decades hot-melt extrusion (HME) has emerged as an influential processing technology in developing molecular dispersions of active pharmaceutical ingredients (APIs) into polymers matrices and has already been demonstrated to provide time controlled, modified, extended and targeted drug delivery resulting in improved bioavailability [
Mohammed Maniruzzaman +3 more
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Application of Lipids in Hot Melt Extrusion Technology [PDF]
, 2023 Lipids are commonly used excipients in drug delivery for improving solubility of low soluble drugs, enhancing bioavailability through avoiding first pass metabolism through nanoparticulate approach, modifying the drug release, binders, permeation ...
Dindigala, Anil Kumar +3 more
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