Results 21 to 30 of about 59,353 (250)

Surviving the heat of the moment : a fungal pathogens perspective [PDF]

, 2013
Peer reviewedPublisher ...
Cowen, Leah E, Leach, Michelle D
core   +2 more sources

Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications

Pharmaceutics, 2022
Heat shock proteins (Hsps) have garnered special attention in cancer therapy as molecular chaperones with regulatory/mediatory effects on folding, maintenance/stability, maturation, and conformation of proteins as well as their effects on prevention of ...
Mina Ardestani, Zahra Khorsandi, Fariba Keshavarzipour, Siavash Iravani, Hojjat Sadeghi-Aliabadi, Rajender S. Varma   +5 more
doaj   +1 more source

Heat stress induces expression of HSP genes in genetically divergent chickens. [PDF]

PLoS ONE, 2017
BACKGROUND:Chickens are animals that are sensitive to thermal stress, which may decrease their production level in terms that it affects feed intake and thus, decreasing body weight gain.
Haniel Cedraz, Juliana Gracielle Gonzaga Gromboni, Antonio Amandio Pinto Garcia, Ronaldo Vasconcelos Farias Filho, Teillor Machado Souza, Eduardo Ribeiro de Oliveira, Elizangela Bonfim de Oliveira, Carlos Souza do Nascimento, Camila Meneghetti, Amauri Arias Wenceslau   +9 more
doaj   +1 more source

Targeting HSP90 as a Novel Therapy for Cancer: Mechanistic Insights and Translational Relevance

Cells, 2022
Heat shock protein (HSP90), a highly conserved molecular chaperon, is indispensable for the maturation of newly synthesized poly-peptides and provides a shelter for the turnover of misfolded or denatured proteins. In cancers, the client proteins of HSP90
Jian Zhang, Houde Li, Yu Liu, Kejia Zhao, Shiyou Wei, Eric T. Sugarman, Lunxu Liu, Gao Zhang   +7 more
doaj   +1 more source

Nuclear HSP90 and HSP70 in COPD patients treated with formoterol or formoterol and corticosteroids

European Journal of Medical Research, 2009
Objective Heat shock proteins assist cellular protein folding and are required for the normal activity of steroid receptors. In this study we assessed nuclear HSP90 and HSP70 proteins and mRNA levels in cells isolated from induced sputum of chronic ...
Holownia A, Mroz RM, Kielek A, Chyczewska E, Braszko JJ   +4 more
doaj   +1 more source

A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90a [PDF]

, 2011
Hsp90α's vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and cell lines validates it as a therapeutic target for glioma.
Adi Mehta, Altieri, Amal Shervington, Bagatell, Basso, Bisht, Boado, Brader, Braga-Basaria, Burger, Chang, Chatterjee, Chinmay Munje, Chiosis, Clarke, Cohen-Saidon, Cruickshanks, Duerfeldt, Elbashir, Eustace, Gaspar, Gazitt, Goetz, Graner, Han, Isaacs, Jane, Kamal, Kamal, Karkoulis, Koren, Kumar, Lang, Lanneau, Leroy Shervington, Li, Luo, McAnuff, McCollum, Padmini, Porter, Pu, Pu, Sauvageot, Schiffelers, Shervington, Shim, Siegelin, Solit, Sreedhar, Stommel, Walsh, Whitesell, Yang, Yen, Yu   +55 more
core   +2 more sources

Heat shock proteins HSP27, HSP60, HSP70, and HSP90 [PDF]

Cancer, 2003
AbstractBACKGROUNDHeat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of HSPs in neoplasia has been implicated in the regulation of apoptosis, and HSPs also can act by increasing immunity. In the current study, the authors attempted to clarify the significance of HSPs in
Thierry, Lebret, R William G, Watson, Vincent, Molinié, Amanda, O'Neill, Christophe, Gabriel, John M, Fitzpatrick, Henry, Botto   +6 more
openaire   +2 more sources

Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals [PDF]

, 2009
Peer reviewedPublisher ...
Brown, Alistair J. P., Leach, Michelle D., Nicholls, Susan, Priest, Claire L.   +3 more
core   +1 more source

Non-enzymatic cleavage of Hsp90 by oxidative stress leads to actin aggregate formation: A novel gain-of-function mechanism

Redox Biology, 2019
Aging is accompanied by the accumulation of oxidized proteins. To remove them, cells employ the proteasomal and autophagy-lysosomal systems; however, if the clearance rate is inferior to its formation, protein aggregates form as a hallmark of ...
José Pedro Castro, Raquel Fernando, Sandra Reeg, Walter Meinl, Henrique Almeida, Tilman Grune   +5 more
doaj   +1 more source

The Onset of Molecule‐Spanning Dynamics in Heat Shock Protein Hsp90

Advanced Science, 2023
AbstractProtein dynamics have been investigated on a wide range of time scales. Nano‐ and picosecond dynamics have been assigned to local fluctuations, while slower dynamics have been attributed to larger conformational changes. However, it is largely unknown how fast (local) fluctuations can lead to slow global (allosteric) changes.
Sohmen, Benedikt, Beck, Christian, Frank, Veronika, Seydel, Tilo, Hoffmann, Ingo, Hermann, Bianca, Nüesch, Mark, Grimaldo, Marco, Schreiber, Frank, Wolf, Steffen, Roosen‐runge, Felix, Hugel, Thorsten   +11 more
openaire   +6 more sources