Results 11 to 20 of about 109,486 (229)

Anti-HSV-1 agents: an update [PDF]

Frontiers in Pharmacology
Herpes simplex virus type I (HSV-1) is a member of the α-herpesvirus subfamily and is capable of causing herpes simplex keratitis, herpes labialis, and herpes simplex encephalitis. HSV-1 is well known for its lytic infections at the primary sites and for establishing latency in the sensory neuronal ganglia, with occasional recurrent infections. To date,
Wenwen Lv, Lei Zhou, Jia Wu, Jishuai Cheng, Yongzhong Duan, Wen Qian   +5 more
openaire   +4 more sources

Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012. [PDF]

PLoS ONE, 2015
BackgroundHerpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection.
Katharine J Looker, Amalia S Magaret, Margaret T May, Katherine M E Turner, Peter Vickerman, Sami L Gottlieb, Lori M Newman   +6 more
doaj   +5 more sources

Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia. [PDF]

PLoS Pathogens, 2013
Herpes simplex virus type 1 (HSV-1) infection results in lifelong chronic infection of trigeminal ganglion (TG) neurons, also referred to as neuronal HSV-1 latency, with periodic reactivation leading to recrudescent herpetic disease in some persons.
Monique van Velzen, Lichen Jing, Albert D M E Osterhaus, Alessandro Sette, David M Koelle, Georges M G M Verjans   +5 more
doaj   +6 more sources

Natural infection with herpes simplex virus type 1 (HSV-1) induces humoral and T cell responses to the HSV-1 glycoprotein H:L complex [PDF]

, 2000
The glycoproteins of herpes simplex virus type 1 (HSV-1) are important targets for the immune system in the control of HSV-1 infections. The humoral and T cell responses to the glycoprotein (g)H(t(His)):gL complex of HSV-1 were ...
Kooij, A. van, Osterhaus, A.D.M.E. (Albert), Scheffer, A.J., The, T.H., Verjans, G.M.G.M. (George), Welling, G.W. (Gjalt), Welling-Wester, S. (Sytske), Westra, D.F.   +7 more
core   +3 more sources

Protection of Mice by an Apathogenic Strain of HSV-1 Against Lethal Infection by a Pathogenic Strain of HSV-1

Journal of General Virology, 1981
DBA/2 and C57BL/6 mice were infected intraperitoneally with two different strains of herpes simplex virus type 1, HSV-1 ANG and HSV-1 WAL. Unlike HSV-1 WAL, HSV-1 ANG was apathogenic by this mode of infection. Furthermore, infection with HSV-1 ANG protected mice of both inbred strains against infections with lethal doses of pathogenic HSV-1 WAL.
Helmut Engler, Holger Kirchner, Claus H. Schröder   +2 more
openaire   +4 more sources

Amplification of reiterated sequences of herpes simplex virus type 1 (HSV-1) genome to discriminate between clinical HSV-1 isolates. [PDF]

, 1999
Herpes simplex virus type 1 (HSV-1)-related disease ranges from a localized, self-limiting illness to fatal disease in immunocompromised individuals. The corneal disease herpetic keratitis may develop after reactivation of a latent virus or reinfection ...
Buitenwerf, J. (Johannes), Lelij, A. (Allegonda) van der, Maertzdorf, J. (Jeroen), Niesters, H.G.M. (Bert), Osterhaus, A.D.M.E. (Albert), Remeijer, L. (Lies), Verjans, G.M.G.M. (George)   +6 more
core   +5 more sources

Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent [PDF]

, 2011
Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s).
Geraghty, R.J., Hsu, M.-J., Knebel-Mörsdorf, D., Petermann, P., Rahn, E., Rixon, F.J.   +5 more
core   +25 more sources

The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons [PDF]

, 2016
open access articleHerpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced.
Coleman, Heather M., Connor, Viv, Efstathiou, Stacey, Hann, William, Harman, Laura E.R., Nicoll, Michael P., Proenca, Joao T., Shivkumar, Maitreyi   +7 more
core   +21 more sources

HSV-1 Amplicon Vectors—Simplicity and Versatility [PDF]

Molecular Therapy, 2000
Cornel Fraefel, Xandra O. Breakefield, Miguel Sena-Esteves, Yoshinaga Saeki   +3 more
openaire   +4 more sources

Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage

Kurdistan Journal of Applied Research, 2018
Among many viral causes of miscarriage, maternal infections caused by herpes simplex virus type -1 (HSV-1) and Herpes simplex virus type-2 (HSV-2) infections are important causes.
Zainab A. Hamid, Solaf J. Ali, Ali Hattem Hussain   +2 more
doaj   +3 more sources