Results 11 to 20 of about 83,455 (287)

A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1

Viruses, 2023
HSV-1 disease is a significant public health burden causing orofacial, genital, cornea, and brain infection. We previously reported that a trivalent HSV-2 gC2, gD2, gE2 nucleoside-modified mRNA-lipid nanoparticle (LNP) vaccine provides excellent ...
Kevin P. Egan, Sita Awasthi, Giulia Tebaldi, Lauren M. Hook, Alexis M. Naughton, Bernard T. Fowler, Mitchell Beattie, Mohamad-Gabriel Alameh, Drew Weissman, Gary H. Cohen, Harvey M. Friedman   +10 more
doaj   +1 more source

Understanding HSV‐1 entry glycoproteins [PDF]

Reviews in Medical Virology, 2007
AbstractHerpes Simplex Virus‐1 is a common infectious agent, but the precise detail of entry and infection of cells has only now begun to be clarified. Four viral surface glycoproteins (gB, gD, gH and gL) are required. This review summarises the known structure and function of each of these essential viral envelope glycoproteins, and explores what is ...
Adi, Reske, Gabriele, Pollara, Claude, Krummenacher, Benjamin M, Chain, David R, Katz   +4 more
openaire   +2 more sources

Herpes Simplex Virus Mistyping due to HSV-1 × HSV-2 Interspecies Recombination in Viral Gene Encoding Glycoprotein B

Viruses, 2020
Human herpes simplex viruses (HSV) 1 and 2 are extremely common human pathogens with overlapping disease spectra. Infections due to HSV-1 and HSV-2 are distinguished in clinical settings using sequence-based “typing” assays.
Amanda M. Casto, Meei-Li W. Huang, Hong Xie, Keith R. Jerome, Anna Wald, Christine M. Johnston, Alexander L. Greninger   +6 more
doaj   +1 more source

Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage

Kurdistan Journal of Applied Research, 2018
Among many viral causes of miscarriage, maternal infections caused by herpes simplex virus type -1 (HSV-1) and Herpes simplex virus type-2 (HSV-2) infections are important causes.
Zainab A. Hamid, Solaf J. Ali, Ali Hattem Hussain   +2 more
doaj   +3 more sources

Novel transcription regulatory sequences and factors of the immune evasion protein ICP47 (US12) of herpes simplex viruses

Virology Journal, 2020
Background Herpes simplex virus (HSV) can cause encephalitis. Its infected cell polypeptide 47 (ICP47), encoded by immediate-early gene US12, promotes immune escape. ICP47 was modified in the clinically approved oncolytic HSV (oHSV) T-Vec.
Jun-Ting Cheng, Ying-Ying Wang, Lin-Zhong Zhu, Ying Zhang, Wen-Qi Cai, Zi-Wen Han, Yang Zhou, Xian-Wang Wang, Xiao-Chun Peng, Ying Xiang, Hui-Yu Yang, Shu-Zhong Cui, Zhaowu Ma, Bing-Rong Liu, Hong-Wu Xin   +14 more
doaj   +1 more source

Variant Analysis of the Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus in Korea: Frequency of Acyclovir Resistance Mutations

Viruses, 2023
The thymidine kinase (TK) and DNA polymerase (pol) genes of the herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are two important genes involved in antiviral resistance.
Jungwon Hyun, Su Kyung Lee, Ji Hyun Kim, Eun-Jung Cho, Han-Sung Kim, Jae-Seok Kim, Wonkeun Song, Hyun Soo Kim   +7 more
doaj   +1 more source

Seroprevalence of herpes simplex virus type 1 and type 2 among the migrant workers in Qatar

Virology Journal, 2023
Background Limited data exists on herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections in migrant populations. This study investigated HSV-1 and HSV-2 seroprevalences and associations among craft and manual workers (CMWs) in Qatar who ...
Gheyath K. Nasrallah, Soha R. Dargham, Duaa W. Al-Sadeq, Fathima H. Amanullah, Farah M. Shurrab, Parveen B. Nizamuddin, Hiam Chemaitelly, Houssein H. Ayoub, Sami Abdeen, Ashraf Abdelkarim, Faisal Daraan, Ahmed Ismail, Nahid Mostafa, Mohamed Sahl, Jinan Suliman, Elias Tayar, Hasan Ali Kasem, Meynard J. A. Agsalog, Bassam K. Akkarathodiyil, Ayat A. Alkhalaf, Mohamed Morhaf M. H. Alakshar, Abdulsalam Ali A. H. Al-Qahtani, Monther H. A. Al-Shedifat, Anas Ansari, Ahmad Ali Ataalla, Sandeep Chougule, Abhilash K. K. V. Gopinathan, Feroz J. Poolakundan, Sanjay U. Ranbhise, Saed M. A. Saefan, Mohamed M. Thaivalappil, Abubacker S. Thoyalil, Inayath M. Umar, Einas Al Kuwari, Peter Coyle, Andrew Jeremijenko, Anvar Hassan Kaleeckal, Hanan F. Abdul Rahim, Hadi M. Yassine, Asmaa A. Al Thani, Odette Chaghoury, Mohamed Ghaith Al Kuwari, Elmoubasher Farag, Roberto Bertollini, Hamad Eid Al Romaihi, Abdullatif Al Khal, Mohamed H. Al-Thani, Laith J. Abu-Raddad   +47 more
doaj   +1 more source

HSV-1 Cytoplasmic Envelopment and Egress [PDF]

International Journal of Molecular Sciences, 2020
Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA replication, capsid assembly, and genome packaging take place in the infected cell nucleus, which mature nucleocapsids exit by envelopment at the inner nuclear membrane then de ...
Imran Ahmad, Duncan W. Wilson
openaire   +2 more sources

Soroprevalência de anticorpos contra vírus herpes simples 1-2 no Brasil Seroprevalencia de anticuerpos contra virus herpes simples 1-2 en Brasil Seroprevalence of herpes simplex 1-2 antibodies in Brazil

Revista de Saúde Pública, 2010
OBJETIVO: Estimar a soroprevalência de anticorpos por vírus herpes simples (HSV-1 e HSV-2) e analisar fatores associados no Brasil. MÉTODOS: Estudo transversal realizado entre 1996 e 1997 em 1.090 indivíduos com idade entre um e 40 anos da população ...
Sue Ann Costa Clemens, Calil Kairalla Farhat   +1 more
doaj   +1 more source

Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia. [PDF]

PLoS Pathogens, 2013
Herpes simplex virus type 1 (HSV-1) infection results in lifelong chronic infection of trigeminal ganglion (TG) neurons, also referred to as neuronal HSV-1 latency, with periodic reactivation leading to recrudescent herpetic disease in some persons.
Monique van Velzen, Lichen Jing, Albert D M E Osterhaus, Alessandro Sette, David M Koelle, Georges M G M Verjans   +5 more
doaj   +1 more source