MiR-155-5p modulates HSV-1 replication via the epigenetic regulation of SRSF2 gene expression
Epigenetics, 2019 A previous study reported that miR-155-5p knockout mice were more resistant to herpes simplex virus type I (HSV-1) infection. However, the exact underlying molecular mechanism remains to be elucidated.
Ziqiang Wang +3 more
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Seroprevalence of Herpes Simplex Virus Type-1 IgG Antibody in Healthy Blood Donor from Baghdad, Iraq
Journal of Pure and Applied Microbiology, 2019 Herpes simplex virus type 1 (HSV-1) is a common infectious agent worldwide. It can cause earnest illnesses at each stage of life. Data on seroprevalence of HSV-1 antibody (Ab) in Iraqi population is limited.
Arwa Mujahid Abdullah Al-Shuwaikh +2 more
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PLoS Pathogens, 2014 Interferon-γ inducible factor 16 (IFI16) is a multifunctional nuclear protein involved in transcriptional regulation, induction of interferon-β (IFN-β), and activation of the inflammasome response. It interacts with the sugar-phosphate backbone of dsDNA and modulates viral and cellular transcription through largely undetermined mechanisms.
Virginie Bottero +5 more
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Вопросы вирусологии, 2017 We have developed a multiplex immunoassay test (immunochip) based on PHOSPHAN technology for the detection of immunoglobulin G to herpes simplex virus (HSV) types 1, 2 and cytomegalovirus (CMV).
A. V. Nikitina +3 more
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A novel method to titrate Herpes simplex virus-1 (HSV-1) using laser-based scanning of near-infrared fluorophores conjugated antibodies [PDF]
, 2017 Among several strategies used for Herpes simplex virus (HSV) detection in biological specimens, standard plaque assay (SPA) remains the most reliable method to evaluate virus infectivity and quantify viral replication.
Anna Teresa Palamara +5 more
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A Host MicroRNA Brokers Truce with HSV-1 [PDF]
Cell Host & Microbe, 2014 Establishing lifelong infection and periodically shedding infectious progeny is a successful strategy employed by several persistent pathogens. In this issue of Cell Host & Microbe, Pan et al. (2014) demonstrate that a cell-type-specific host microRNA can restrict gene expression and pathogenicity of herpes simplex virus 1, thereby promoting long-term ...
Christopher S. Sullivan, Justin M. Pare
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A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro [PDF]
, 2015 The ubiquitin–proteasome system is an essential cellular process that plays a fundamental role in the regulation of protein stability. This pathway is tightly controlled by a sequential cascade of enzymatic steps that culminates in the formation of a ...
Boutell, Chris, Davido, David J.
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Potential for HSV-1 vaccination to reduce risk of HSV-1 encephalitis and/or Alzheimer’s disease?
Neurobiology of Aging, 2001 Professor Itzhaki and her team report an interesting experiment in which vaccination of mice with mixed HSV-1 glycoproteins significantly reduced detectable latent HSV-1 in brain (from 41% to 7%) 5 months after subsequent challenge by ear scarification with a non-lethal dose of HSV-1 [18]. This work follows the earlier demonstration by other groups [6 –
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Improved Long-term Expression from Helper Virus-free HSV-1 Vectors Packaged Using Combinations of Mutated HSV-1 Proteins that Include the UL13 Protein Kinase and Specific Components of the VP16 Transcriptional Complex [PDF]
, 2011 Background: Herpes Simplex Virus (HSV-1) gene expression is thought to shut off recombinant gene expression from HSV-1 vectors; however, in a helper virus-free HSV-1 vector system, a number of promoters support only short-term expression.
Geller, Alfred I. +2 more
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Development of a high specificity typing method for the detection of herpes simplex virus
Frontiers in Bioengineering and Biotechnology, 2022 Herpes disease is caused by Herpes simplex virus (HSV). It has become one of the global health problems. This paper reports a method for HSV type testing. First specific primers sequence for HSV-1 and HSV-2 were selected, designed, and synthesized. Then,
Zhu Chen +11 more
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