Mice microglia cytokine profile changes under the influence of HSV-1
Инфекция и иммунитетIntroduction. Today, prevalence of neurodegenerative diseases increases. In recent years, more studies have revealed a new knowledge about the role of microglia in the development of these diseases.
Irina D. Bulgakova +6 more
doaj +1 more source
A Phospho-SIM in the Antiviral Protein PML is Required for Its Recruitment to HSV-1 Genomes [PDF]
, 2014 Herpes simplex virus type 1 (HSV-1) is a significant human pathogen that infects a large portion of the human population. Cells deploy a variety of defenses to limit the extent to which the virus can replicate.
Box, Andrew C. +4 more
core +3 more sources
Interferon alpha suppresses alphaherpesvirus immediate early protein levels in sensory neurons, leading to the establishment of a latent infection [PDF]
, 2010 Alphaherpesviruses are a subfamily of the herpesviruses containing closely related human and animal pathogens, including human herpes simplex virus (HSV-1) and porcine pseudorabies virus (PRV)
De Regge, Nick +4 more
core
Coincident onset of multiple sclerosis and herpes simplex virus 1 encephalitis. a case report [PDF]
, 2017 Background: Along with vitamin D, smoking, body mass index and others, Epstein Barr virus, other herpesviruses and human endogenous retroviruses represent plausible environmental risk factors for multiple sclerosis.
Buscarinu, M. C. +7 more
core +2 more sources
Оцінка антивірусної активності препарату рибамідил на моделі змішаної адено-герпетичної інфекції [PDF]
, 2014 Створено модель змiшаної адено-герпетичної iнфекцiї клiтин MDBK та охарактеризовано особливостi репродукцiї вiрусiв. Одночасне iнфiкування клiтин двома вiрусами призводить до взаємного пригнiчення репродукцiї вiрусiв; суперiнфiкування клiтин HSV-1/US ...
Бобко, Т.М. +4 more
core +1 more source
Herpes simplex virus type 1 and 2 in mucocutaneous infections
Journal of Oral Microbiology, 2017 Herpes simplex virus (HSV) type 1 and 2 are both known to cause mucosal and skin infections. HSV-1 is regarded as the main virus type in the orofacial region, whereas HSV-2 is mainly associated with genital infections.
Hannamari Välimaa
doaj +1 more source
Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling
mBio, 2019 TANK-binding kinase 1 (TBK1) is a key component of the antiviral immunity signaling pathway. It activates downstream interferon regulatory factor 3 (IRF3) and subsequent type I interferon (IFN-I) production.
Hongjuan You +5 more
doaj +1 more source
The lysosome system is severely impaired in a cellular model of neurodegeneration induced by HSV-1 and oxidative stress [PDF]
, 2018 The causal agent(s) and molecular mechanisms of Alzheimer's disease (AD) remain unclear. Mounting evidence suggests that herpes simplex virus type 1 (HSV-1) infection is involved in the AD pathogenesis. Oxidative stress (OS) may also be crucial in the AD
Aludo, Jesús +5 more
core +1 more source
Melissa officinalis extract inhibits attachment of herpes simplex virus in vitro [PDF]
, 2012 Background: Extracts and essential oils of medicinal plants are increasingly of interest as novel drugs for antiherpetic agents, since the herpes simplex virus (HSV) might develop resistance to commonly used antiviral drugs.
Astani, Akram +2 more
core +1 more source
Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2
Frontiers in Microbiology, 2019 Omeprazole was shown to improve the anti-cancer effects of the nucleoside analogue 5-fluorouracil. Here, we combined omeprazole with the antiviral nucleoside analogues ribavirin and acyclovir.
Martin Michaelis +5 more
doaj +1 more source