Results 211 to 220 of about 63,605 (287)

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen, Tao‐Tao Shi, Dan‐Yang Hu, Xiao‐Na Su, Jian‐Xiang Jin, Mao‐Song Chen, Hao Wang, Wei Chen   +7 more
wiley   +1 more source

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu, Jui‐Ning Yeh, Han‐Tan Chai, John Y. Chiang, Chi‐Ruei Huang, Jun Guo, Hon‐Kan Yip   +6 more
wiley   +1 more source

The effect of biological control on mycotoxin concentrations and the mycobiome in durum wheat grain and stems. [PDF]

Sci Rep
Wachowska U, Sulyok M, Wiwart M, Suchowilska E, Giedrojć W, Stuper-Szablewska K, Kandler W, Krska R.   +7 more
europepmc   +1 more source

Ear Piercing Complications: Comparing Cartilage and Soft Tissue Piercings in a Large Survey Cohort

The Laryngoscope, EarlyView.
Cartilage ear piercings were associated with significantly higher complication rates than lobule piercings and remained an independent predictor of complications after multivariate analysis. Cartilage site also independently predicted piercing removal, with higher removal rates observed compared to lobule piercings.
John P. Ziegler, Nitin A. Pagedar, McKay Moline, Kathryn Marcus, Zachary G. Tanenbaum, Henry T. Hoffman, Scott R. Owen   +6 more
wiley   +1 more source

Assessing NaV1.7 during tonic firing in pig C-nociceptors. [PDF]

PLoS One
Soares S, Schmelz M, Carr R, Sohns K, Rukwied R.   +4 more
europepmc   +1 more source

CardiacDP: An R package for rapid automated cardiac data processing, integrating autocorrelation, a genetic algorithm, and a tracking index

Limnology and Oceanography: Methods, EarlyView.
Abstract Heart rate is a popular proxy of physiological responses, but the highly complex and variable cardiac data obtained from organisms such as marine invertebrates pose a major challenge to efficient and accurate data processing. To address this, we developed a novel, integrative algorithm for rapid and automated cardiac data processing.
Sarah L. Y. Lau, Adrian T. C. Wong, Yi‐Fei Gu, Tin Yan Hui   +3 more
wiley   +1 more source

Mycotoxins in Fish Aquaculture-Occurrence and Future Perspective. [PDF]

Foods
Vulić A, Kudumija N, Šegvić-Bubić T, Lešić T.   +3 more
europepmc   +1 more source

Health Problems with Mycotoxins in Cattle-A Review. [PDF]

Molecules
Radko L, Dudek K, Żakowicz P, Smulski S, Kozdrowski R.   +4 more
europepmc   +1 more source

Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao, Kazuya Kawabata, Yasuaki Mizutani, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Yasuhiro Maeda, Akihiro Mouri, Hirohisa Watanabe   +8 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source