Results 1 to 10 of about 165,036 (300)

Requirements for human cardiomyocytes. [PDF]

Cell Prolif, 2022
Abstract‘Requirements for human cardiomyocytes', jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human cardiomyocytes in China. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packing requirements ...
Yu M, Lei W, Cao J, Wang L, Ma A, Zhao ZA, Yang HT, Shen Z, Lan F, Cao F, Liang P, Pei X, Xiang AP, Yu J, Zhang Y, Zhang Y, Li Q, Zhou J, Wei J, Peng Y, Zhu H, Liang L, Cao N, Fu B, Hao J, Zhao T, Hu S.   +26 more
europepmc   +4 more sources

Human cardiomyocytes for drug discovery

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018
Introduction: Cardiac drug discovery are based in old methods that use animals, animal cells or modified cells that do not faithfully represent human cardiac phenotypes.
Diogo Gonçalves Biagi, Jéssica Gonçalves, Estela Cruvinel, Renata Damiani, Flavia Valgode, Fabiana Medeiros, Camila G Moreira, Evelyn Santos, Rodrigo Marcon, Calixto João, Gabriela Venturini, Alexandre Pereira, Éden Ferreira, Renato Mortara, Marcos C Valadares   +14 more
doaj   +8 more sources

SNTA1-deficient human cardiomyocytes demonstrate hypertrophic phenotype and calcium handling disorder [PDF]

Stem Cell Research & Therapy, 2022
Background α-1-syntrophin (SNTA1), a protein encoded by SNTA1, is highly expressed in human cardiomyocytes. Mutations in SNTA1 are associated with arrhythmia and cardiomyopathy. Previous research on SNTA1 has been based on non-human cardiomyocytes.
Tao Dong, Yan Zhao, Hai-Feng Jin, Lei Shen, Yan Lin, Long-Long Si, Li Chen, Ji-Cheng Liu   +7 more
doaj   +2 more sources

Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges—The Hamburg perspective

Frontiers in Physiology, 2023
Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a ...
Djemail Ismaili, Djemail Ismaili, Djemail Ismaili, Carl Schulz, Carl Schulz, András Horváth, Jussi T. Koivumäki, Delphine Mika, Arne Hansen, Arne Hansen, Thomas Eschenhagen, Thomas Eschenhagen, Torsten Christ, Torsten Christ   +13 more
doaj   +1 more source

Potential Role of Lisinopril in Reducing Atherosclerotic Risk: Evidence of an Antioxidant Effect in Human Cardiomyocytes Cell Line

Frontiers in Pharmacology, 2022
The cellular mechanisms involved in myocardial ischemia/reperfusion injury (I/R) pathogenesis are complex but attributable to reactive oxygen species (ROS) production.
Lucia Scisciola, Rosaria Anna Fontanella, Surina, Giovanna Garofalo, Maria Rosaria Rizzo, Giuseppe Paolisso, Giuseppe Paolisso, Michelangela Barbieri   +7 more
doaj   +1 more source

MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A

Anatolian Journal of Cardiology, 2022
Background: Myocardial infarction, a coronary heart disease, is a serious hazard to human health. Cardiomyocyte oxidative stress and apoptosis have been considered as the main causes of myocardial infarction. Here, we aimed to investigate the role of miR-
Dongying Zhang, Gang Zhang, Kun Yu, Xiwen Zhang, Aixia Jiang   +4 more
doaj   +1 more source

Cardiomyocyte Renewal in Humans [PDF]

Circulation Research, 2012
Pas de ...
Bergmann, Olaf, Zdunek, Sofia, Frisén, Jonas, Bernard, Samuel, Druid, Henrik, Jovinge, Stefan   +5 more
openaire   +4 more sources

Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids [PDF]

Scientific Reports, 2018
AbstractHuman amniotic fluid (hAF) cells share characteristics of both embryonic and adult stem cells. They proliferate rapidly and can differentiate into cells of all embryonic germ layers but do not form teratomas. Embryoid-bodies obtained from hAF have cardiac differentiation potential, but terminal differentiation to cardiomyocytes (CMs) has not ...
Di Baldassarre, Angela, D’Amico, Maria A., Izzicupo, Pascal, Gaggi, Giulia, Guarnieri, Simone, Mariggiò, Maria A., Antonucci, Ivana, Corneo, Barbara, Sirabella, Dario, Stuppia, Liborio, Ghinassi, Barbara   +10 more
openaire   +2 more sources

Identification of miRNAs as Biomarkers of Cardiac Protection in Non-Genetically Modified Primary Human Cardiomyocytes Exposed to Halogenated Hypnotics in an In Vitro Model of Transfection and Ischemia/Reperfusion: A New Model in Translational Anesthesia

Life, 2022
Background: Many clinical studies have identified some circulating micro-RNAs (miRNAs) as potential biomarkers with regard to the cardioprotective effects of halogenated agents administered perioperatively during myocardial conditioning procedures ...
Maria Dolores Carmona-Luque, Laura Gonzalez-Alvarez, José Luis Guerrero Orriach   +2 more
doaj   +1 more source

Evidence for Cardiomyocyte Renewal in Humans [PDF]

Science, 2009
It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes
Bergmann, Olaf, Bhardwaj, Ratan D, Bernard, Samuel, Zdunek, Sofia, Barnabé-Heider, Fanie, Walsh, Stuart, Zupicich, Joel, Alkass, Kanar, Buchholz, Bruce A, Druid, Henrik, Jovinge, Stefan, Frisén, Jonas   +11 more
openaire   +3 more sources