Results 31 to 40 of about 165,036 (300)

Effects of local activation times on the tension development of human cardiomyocytes in a computational model

Current Directions in Biomedical Engineering, 2018
The human heart is an organ of high complexity and hence, very challenging to simulate. To calculate the force developed by the human heart and therefore the tension of the muscle fibers, accurate models are necessary.
Müller Armin, Kovacheva Ekaterina, Schuler Steffen, Dössel Olaf, Baron Lukas   +4 more
doaj   +2 more sources

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy

Frontiers in Physiology, 2018
Hypertrophic Cardiomyopathy (HCM) has been related to many different mutations in more than 20 different, mostly sarcomeric proteins. While development of the HCM-phenotype is thought to be triggered by the different mutations, a common mechanism remains
Judith Montag, Kathrin Kowalski, Mirza Makul, Pia Ernstberger, Ante Radocaj, Julia Beck, Edgar Becker, Snigdha Tripathi, Britta Keyser, Christian Mühlfeld, Kirsten Wissel, Andreas Pich, Jolanda van der Velden, Cristobal G. dos Remedios, Andreas Perrot, Antonio Francino, Francesco Navarro-López, Bernhard Brenner, Theresia Kraft   +18 more
doaj   +1 more source

Ion Channel Expression and Electrophysiology of Singular Human (Primary and Induced Pluripotent Stem Cell-Derived) Cardiomyocytes

Cells, 2021
Subtype-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are promising tools, e.g., to assess the potential of drugs to cause chronotropic effects (nodal hiPSC-CMs), atrial fibrillation (atrial hiPSC-CMs), or ventricular ...
Christina Schmid, Najah Abi-Gerges, Michael Georg Leitner, Dietmar Zellner, Georg Rast   +4 more
doaj   +1 more source

Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1

Frontiers in Pharmacology, 2017
Background and Aims: Tongxinluo (TXL) is a multifunctional traditional Chinese medicine that has been widely used to treat cardiovascular and cerebrovascular diseases.
Gui-hao Chen, Chuan-sheng Xu, Jie Zhang, Qing Li, He-he Cui, Xiang-dong Li, Li-ping Chang, Rui-jie Tang, Jun-yan Xu, Xia-qiu Tian, Pei-sen Huang, Jun Xu, Chen Jin, Yue-jin Yang   +13 more
doaj   +1 more source

Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]

, 2016
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia, Brock, Mathew, Chan, Dulciana, Chvatal, Stacie, Crumb, William J., Galeotti, Loriano, Hortigon-Vinagre, Maria P., Johannesen, Lars, Lyn-Cook, Beverly, Millard, Daniel, Pang, Li, Ross, James, Smith, Godfrey, Stockbridge, Norman, Stohlman, Jayna, Strauss, David G., Vicente, Jose, Zamora Rodriguez, Victor   +17 more
core   +1 more source

Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes [PDF]

Toxicological Sciences, 2014
Functional changes to cardiomyocytes are a common cause of attrition in preclinical and clinical drug development. Current approaches to assess cardiomyocyte contractility in vitro are limited to low-throughput methods not amenable to early drug discovery.
Amy, Pointon, Alexander R, Harmer, Ian L, Dale, Najah, Abi-Gerges, Joanne, Bowes, Christopher, Pollard, Helen, Garside   +6 more
openaire   +2 more sources

Gap junction reduction in cardiomyocytes following transforming growth factor- beta treatment and Trypanosoma cruzi infection [PDF]

, 2009
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta).
Becker, D, Burnstock, G, Coutinho-Silva, R, de Araujo-Jorge, TC, Feige, JJ, Higuchi, MD, Waghabi, MC   +6 more
core   +2 more sources

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. [PDF]

, 2017
The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation.
Braas, Daniel, Christofk, Heather, Clark, Peter M, Ding, Xueqin, Dunham, Christopher, Fu, Kai, Gimzewski, James K, Kurdistani, Siavash K, Lusis, Aldons J, Minami, Itsunari, Morselli, Marco, Nakano, Atsushi, Nakano, Haruko, Nakatsuji, Norio, Pappoe, Herman, Pellegrini, Matteo, Reue, Karen, Ribalet, Bernard, Sagadevan, Addelynn, Stieg, Adam Z, Vergnes, Laurent, Wu, Xiuju   +21 more
core   +2 more sources

Deriving Cardiomyocytes from Human Amniocytes [PDF]

, 2018
ABSTRACTMany forms of congenital heart disease (CHD) have high morbidity-mortality rates and require challenging surgeries. Human amniocytes have important stem cell characteristics and could potentially provide patient-specific tissue for repairs of some types of CHDs. We report that amniocytes express features of poised cardiomyocytes.
Maguire, Colin T., Sunderland, Ryan, Demarest, Bradley, Gorsi, Bushra, Jackson, Josh, Lopez-Izquierdo, Angelica, Tristani-Firouzi, Martin, Yost, H. Joseph, Condic, Maureen L.   +8 more
openaire   +1 more source

Telomere‐independent cellular senescence in human fetal cardiomyocytes [PDF]

Aging Cell, 2004
SummaryFetal cardiomyocytes have been proposed as a potential source of cell‐based therapy for heart failure. This study examined cellular senescence in cultured human fetal ventricular cardiomyocytes (HFCs). HFCs were isolated and identified by immunocytochemistry and RT‐PCR.
Ball, Andrew J, Levine, F
openaire   +3 more sources