Results 51 to 60 of about 165,036 (300)

In-silico analysis of aging mechanisms of action potential remodeling in human atrial cardiomyocites

BIO Web of Conferences, 2020
Electrophysiology of cardiomyocytes changes with aging. Agerelated ionic remodeling in cardiomyocytes may increase the incidence and prevalence of atrial fibrillation (AF) in the elderly and affect the efficiency of antiarrhythmic drugs.
Nesterova Tatyana, Shmarko Dmitry, Ushenin Konstantin, Solovyova Olga   +3 more
doaj   +1 more source

Cardiomyocyte Regeneration in Human Myocarditis

European Heart Journal
Background : Newly generated cardiomyocytes (NGC) concur to recovery of human myocarditis. However, Methods: We retrospectively assessed NGC in 213 consecutive patients with endomyocardial biopsy denoting acute myocarditis, with normal coronaries and valves.
Andrea Frustaci, Eleonora Foglio, Federica Limana, Michele Magnocavallo, Emanuela Frustaci, Leonardo Lupacchini, Romina Verardo   +6 more
openaire   +3 more sources

MicroRNA-197-3p Transfection: Variations in Cardiomyocyte Gene Expression with Anaesthetics Drugs in a Model of Hypoxia/Reperfusion

Pharmaceuticals
Background: Our research team analyzed the microRNA (miRNA)-197-3p involved in cardioprotection, and we demonstrated that the overexpression of miRNA-197-3p could be linked to a higher risk of cardiac damage.
Jose Luis Guerrero-Orriach, Maria Dolores Carmona-Luque, Maria Jose Rodriguez-Capitan, Guillermo Quesada-Muñoz   +3 more
doaj   +1 more source

Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes

Stem Cell Research & Therapy, 2017
Background Most infarctions occur in the left anterior descending coronary artery and cause myocardium damage of the left ventricle. Although current pluripotent stem cells (PSCs) and directed cardiac differentiation techniques are able to generate fetal-
Bin Li, Hui Yang, Xiaochen Wang, Yongkun Zhan, Wei Sheng, Huanhuan Cai, Haoyang Xin, Qianqian Liang, Ping Zhou, Chao Lu, Ruizhe Qian, Sifeng Chen, Pengyuan Yang, Jianyi Zhang, Weinian Shou, Guoying Huang, Ping Liang, Ning Sun   +17 more
doaj   +1 more source

Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo. [PDF]

PLoS ONE, 2013
BACKGROUND: Definite identification of the cell types and the mechanism relevant to cardiomyogenesis is essential for effective cardiac regenerative medicine.
Mitsuhiro Fukata, Fumihiko Ishikawa, Yuho Najima, Takuji Yamauchi, Yoriko Saito, Katsuto Takenaka, Kohta Miyawaki, Hideki Shimazu, Kazuya Shimoda, Takaaki Kanemaru, Kei-Ichiro Nakamura, Keita Odashiro, Koji Nagafuji, Mine Harada, Koichi Akashi   +14 more
doaj   +1 more source

Adenine Nucleotide Translocase 1 Expression is Coupled to the HSP27-Mediated TLR4 Signaling in Cardiomyocytes [PDF]

, 2019
The cardiac-specific overexpression of the adenine nucleotide translocase 1 (ANT1) has cardioprotective effects in various experimental heart disease models.
Dörner, Andrea, Hammer, Elke, Heger, Jacqueline, Landmesser, Ulf, Rauch, Ursula, Schultheiss, Heinz-Peter, Winter, Julia   +6 more
core   +2 more sources

A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes

Communications Biology, 2022
An altered automated patch-clamp (APC) approach enables high-throughput recordings from native pig cardiomyocytes and human iPSC-derived cardiomyocytes.
Fitzwilliam Seibertz, Markus Rapedius, Funsho E. Fakuade, Philipp Tomsits, Aiste Liutkute, Lukas Cyganek, Nadine Becker, Rupamanjari Majumder, Sebastian Clauß, Niels Fertig, Niels Voigt   +10 more
doaj   +1 more source

High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias

Frontiers in Pharmacology, 2021
Evaluation of proarrhythmic properties is critical for drug discovery. In particular, QT prolongation in electrocardiograms has been utilized as a surrogate marker in many evaluation systems to assess the risk of torsade de pointes and lethal ventricular
Yayoi Honda, Yayoi Honda, Jun Li, Jun Li, Aya Hino, Shinji Tsujimoto, Jong-Kook Lee   +6 more
doaj   +1 more source

Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells. [PDF]

, 2015
The treatment of myocardial infarction is a major challenge in medicine due to the inability of heart tissue to regenerate. Direct reprogramming of endogenous cardiac fibroblasts into functional cardiomyocytes via the delivery of transcription factor ...
Kim, Hyun Jin, Lee, Kunwoo, Lingampalli, Nithya, Murthy, Niren, Tang, Richard, Yu, Pengzhi   +5 more
core   +3 more sources

Stimulation of Cardiomyocyte Proliferation Is Dependent on Species and Level of Maturation

Frontiers in Cell and Developmental Biology, 2022
The heart is one of the least regenerative organs. This is in large part due to the inability of adult mammalian cardiomyocytes to proliferate and divide.
Dogacan Yücel, Dogacan Yücel, Bayardo I. Garay, Bayardo I. Garay, Bayardo I. Garay, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Jop H. van Berlo, Jop H. van Berlo, Jop H. van Berlo   +11 more
doaj   +1 more source