Results 61 to 70 of about 165,036 (300)

Sex‐specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles [PDF]

, 2018
Sex has a large influence on cardiac electrophysiological properties. Whether sex differences exist in apamin‐sensitive small conductance Ca2+‐activated K+ (SK) current (IKAS) remains unknown.
Chen, Mu, Chen, Peng-Sheng, Chen, Zhenhui, Everett, Thomas H., IV, Guo, Shuai, Lin, Shien-Fong, Rubart-von der Lohe, Michael, Wang, Zhuo, Weiss, James N., Xu, Dong-Zhu, Yin, Dechun   +10 more
core   +1 more source

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts [PDF]

Nature, 2014
Pluripotent stem cells provide a potential solution to current epidemic rates of heart failure by providing human cardiomyocytes to support heart regeneration. Studies of human embryonic-stem-cell-derived cardiomyocytes (hESC-CMs) in small-animal models have shown favourable effects of this treatment.
Chong, James J. H., Yang, Xiulan, Don, Creighton W., Minami, Elina, Liu, Yen-Wen, Weyers, Jill J., Mahoney, William M., Van Biber, Benjamin, Cook, Savannah M., Palpant, Nathan J., Gantz, Jay A., Fugate, James A., Muskheli, Veronica, Gough, G. Michael, Vogel, Keith W., Astley, Cliff A., Hotchkiss, Charlotte E., Baldessari, Audrey, Pabon, Lil, Reinecke, Hans, Gill, Edward A., Nelson, Veronica, Kiem, Hans-Peter, Laflamme, Michael A., Murry, Charles E.   +24 more
openaire   +3 more sources

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells

Life Science Alliance, 2021
Using genetically encoded Förster resonance energy transfer calcium sensors for the peroxisome, this study dissects the previously contentious peroxisome involvement in calcium handling in HeLa cells and in cardiomyocytes derived from human induced ...
Yelena Sargsyan, Uta Bickmeyer, Christine S Gibhardt, Katrin Streckfuss-Bömeke, Ivan Bogeski, Sven Thoms   +5 more
doaj   +1 more source

Centrosome Reduction Promotes Terminal Differentiation of Human Cardiomyocytes [PDF]

Stem Cell Reports, 2020
Centrosome reduction and redistribution of pericentriolar material (PCM) coincides with cardiomyocyte transitions to a post-mitotic and matured state. However, it is unclear whether centrosome changes are a cause or consequence of terminal differentiation.
Ng, Dominic C.H., Richards, Dominic K., Mills, Richard J., Ho, Uda Y., Perks, Hannah L., Tucker, Callum R., Voges, Holly K., Pagan, Julia K., Hudson, James E.   +8 more
openaire   +3 more sources

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Post-TTM Rebound Pyrexia after Ischemia-Reperfusion Injury Results in Sterile Inflammation and Apoptosis in Cardiomyocytes [PDF]

, 2019
Introduction. Fever is frequently observed after acute ischemic events and is associated with poor outcome and higher mortality. Targeted temperature management (TTM) is recommended for neuroprotection in comatose cardiac arrest survivors, but pyrexia ...
Berger, Felix, Garlen, Nalina N. A. von, Krech, Jana, Lam, Phuong D., Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +6 more
core   +1 more source

CHD-associated enhancers shape human cardiomyocyte lineage commitment

eLife, 2022
Enhancers orchestrate gene expression programs that drive multicellular development and lineage commitment. Thus, genetic variants at enhancers are thought to contribute to developmental diseases by altering cell fate commitment. However, while many variant-containing enhancers have been identified, studies to endogenously test the impact of these ...
Sean C Goetsch, Daniel A Armendariz, Anjana Sundarrajan, Sushama Sivakumar, Yihan Wang, Shiqi Xie, Nikhil V Munshi, Gary C Hon   +7 more
openaire   +3 more sources

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Merits of hiPSC-Derived Cardiomyocytes for In Vitro Research and Testing Drug Toxicity

Biomedicines, 2022
The progress of medical technology and scientific advances in the field of anticancer treatment have increased the survival probabilities and duration of life of patients.
Ping-Hsien Wang, Yi-Hsien Fang, Yen-Wen Liu, Min-Long Yeh   +3 more
doaj   +1 more source